PubMed HealthSearch

Biomedical subjects

G Chelazzi

Publications and source records attributed to G Chelazzi.

At least 19 recordsLinked to original sources

Occlusion of the carotid artery as presenting symptom of acute promyelocytic leukemia.

In a 44-year-old female acute promyelocytic leukemia (APL) presented with abrupt onset of right hemiplegia and aphasia due to occlusion of the left carotid artery at bifurcatio. There was laboratory evidence of disseminated intravascular coagulation (DIC). Thrombotic complications are unusual in APL, even in cases with evidence of DIC. This report aims at underlying the important implication of a correct timely diagnosis in young patients presenting with stroke.

Adult

Total serum IgE levels in children with pertussis.

Total serum IgE levels were evaluated in 20 children with pertussis. Increased levels of serum IgE were observed in the group of children between the ages of 3 and 12 years, while normal levels of serum IgE were detected in the groups of children between birth and 24 months old and between 13 and 24 months old. A further and significant increment of serum IgE levels was also found after 10 days of hospitalization.

Age Factors

Plasma fibronectin concentrations in patients with human immunodeficiency virus infection.

Plasma fibronectin (PFN) concentrations were assessed in 21 patients with AIDS, in seven with AIDS-related complex (ARC), in 17 asymptomatic seropositive patients, and in 36 age and sex matched healthy control subjects. A single radial immunodiffusion technique was used to determine PFN concentration. A significant decrease in PFN concentrations was observed in patients with ARC and AIDS (especially in those patients with Pneumocystis carinii pneumonitis). On the other hand, normal PFN concentrations were observed in asymptomatic seropositive patients. The determination of PFN concentration in patients with AIDS and ARC may contribute to the diagnosis of such patients.

AIDS-Related Complex

[Monoclonal gammopathy of uncertain significance in rheumatic disease].

Among 358 patients with rheumatic diseases, the incidence of monoclonal gammopathy of undetermined significance (MGUS) as detected by immunofixation was 4.4% (11 of 248 patients) in rheumatoid arthritis (RA), 3% (1 of 32 patients) in systemic lupus erythematosus (SLE), 6% (3 of 49 patients) in Sjögren's syndrome (SS) and 3% (1 of 29 patients) in progressive systemic sclerosis (PSS). Solid tumor was present in 4 (36%) of the 11 RA-MGUS patients. In these cases the monoclonal component could be related to a paraneoplastic syndrome rather than to rheumatic diseases. The association of rheumatic diseases, MGUS, solid tumor and immunological disorders are discussed.

Adult

[Primary malignant non-Hodgkin's lymphoma of the stomach. Case series contribution].

Fourteen cases of primary gastric non-Hodgkin malignant lymphoma have been classified according to the "Working Formulation for Clinical Usage" and according to the Kiel classification. They have been staged according to the Ann Arbor staging system modified by Musshoff and according to the Manchester staging system modified by Rao. They have been also arranged in the Friedman's macroscopic types. Clinical features, radiologic and endoscopic findings, performed surgical operations, histologic reports and prognostic factors are reported and discussed. The patients, after surgery, have been treated with radiotherapy and/or polychemotherapy, according to the suggested therapeutic pattern. The follow-up has evidenced a better prognosis than gastric carcinoma. The importance of the preoperative diagnosis is emphasized. This is often difficult to obtain, but it permits a better surgical treatment and especially the right intraoperative staging.

Adult

Peripheral blood lymphocyte subpopulations after splenectomy for trauma.

Absolute and percent numbers of peripheral blood lymphocyte (PBL) subpopulations were evaluated using monoclonal antibodies in 20 subjects splenectomised for trauma. A significant increase was observed in the absolute counts of total PBL, B, null and Leu 7+ cells and in the percent counts of null and Leu 7+ lymphocytes. The percent numbers of OKT11+, OKT4+ and OKT8+ lymphocytes were significantly reduced, but the OKT4+/OKT8+ ratio was not statistically different from normal controls. The increase in B and killer/natural killer cells may provide a compensatory mechanism responsible for surveillance against infections and tumors in splenectomised patients, despite the numerous humoral and cellular abnormalities they commonly display.

Adolescent

Characterization of circulating T-lymphocyte subsets in alcoholic liver disease by monoclonal antibodies: correlation with the absolute lymphocyte count.

Peripheral blood T-lymphocytes from 27 patients with alcoholic liver disease were assessed on the basis of their ability to react with OKT monoclonal antibodies. A significant positive correlation was observed between the absolute numbers of T-lymphocytes and suppressor/cytotoxic T cells and the absolute lymphocyte count. These data suggest that quantitative changes in T-lymphocyte subsets in alcoholic liver disease do not necessarily reflect an imbalance in T immunoregulatory mechanisms.

Antibodies, Monoclonal

[Arthrography of the ankle joint].

Arthrography of the ankle joint was first carried out by Johnson and Palmer at the Military Hospital in Stockholm in 1940. Arthrography can be used for judging the integrity of the articular cartilage, of osteochondritis dissecans, arthritis or adhesive capsulitis. The literature shows, however, that more than 95% of the patients on whom this examination has been performed had suffered from acute trauma.

Ankle