[The incidence of isolation of A. israelii in women with an IUD].
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Actinomyces↗
Biomedical subjects
G Chisari
Publications and source records attributed to G Chisari.
Microbiological basis for the use of fosfomycin trometamol as single-dose therapy for simple cystitis.
Fosfomycin trometamol (FOT), a new soluble salt of fosfomycin, was developed especially for single-dose treatment in uncomplicated urinary tract infections. In this study, the minimum inhibitory concentrations (MICs) of FOT were measured both in nutrient broth and human urine and compared with calcium fosfomycin, pipemidic acid and cotrimoxazole. A total of 300 bacterial strains of different species from recent urinary infections were studied. Staphylococcus aureus showed the lowest MIC (0.38 micrograms/ml) and Pseudomonas spp. the highest (50 micrograms/ml) with fosfomycin salts in nutrient broth. The MIC of fosfomycin resulted in being higher than those for pipemidic acid and cotrimoxazole against Escherichia coli and Proteus rettgeri and lower for all the other species considered. The MIC values increased about ten times when urine was used as medium. No differences were observed between the two fosfomycin salts. The fosfomycin concentrations of 137-1500 micrograms/ml, easily obtained in urine of healthy adult subjects after a single dose of FOT (3g of fosfomycin), were able to kill all the strains, with the exception of Streptococcus faecalis. The bacterial adhesion of a resistant microorganism (P. aeruginosa) to the cells of the urinary tract, showed a 50% reduction after FOT treatment.
Bacteria↗
Coaggregation between Actinomyces viscosus with Streptococcus pyogenes and Streptococcus agalactiae.
Interbacterial coaggregation between Actinomyces viscosus indigenous to the human mouth and Streptococcus pyogenes and Streptococcus agalactiae was studied. Fifteen of twenty-six strains of Streptococcus pyogenes and thirteen of thirty-one Streptococcus agalactiae showed a coaggregation with Actinomyces viscosus strain. The results show that the coaggregation mechanism required calcium and was dependent on pH. Some coaggregations were inhibited by 0.06 M. lactose and by 1 M. NaCl.
Actinomyces↗
Visual outcome after excimer laser refractive surgery in adult patients with amblyopia.
PURPOSE: To evaluate the visual and refractive outcome in adult patients wi th refractive and anisometropic amblyopia treated with photorefractive keratectomy. METHODS: An interventional non-comparative study was performed on 50 consecutive patients with amblyopia treated with photorefractive keratectomy. Sixty-eight eyes of 18 participants with bilateral refractive amblyopia and 32 participants with unilateral anisometropic amblyopia were studied. The photorefractive keratectomy was performed with MEL 70 G-Scan excimer laser. Follow-up was 1, 3, 6, and 12 months after the treatment. The mean outcome measures were uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BCVA), refraction, and corneal transparency. RESULTS: In 64.7% of eyes, the UCVA at 12 months after the treatment was better than or equal to their preoperative BCVA. A total of 82.4% of eyes improved their BCVA one or more lines. No eye lost lines of BCVA, 17.6% remained unvaried, 50% gained one line, 20.6 % gained two lines, and 11.8% gained three lines of BCVA. The number of lines gained correlated strongly with diopters of anisometropia between eyes (p<0.01). The mean sphere changed from -5.62+/-3.37 D to -0.47+/-1 D, mean cylinder varied from -2.36+/-1.57 to -0.18+/-0.41 D, and the spherical equivalent varied from -6.82+/-3.1 to -0.45+/-1.08 D. No clinically significant haze was observed. CONCLUSIONS: Excimer laser refractive surgery appears to be a safe and efficient procedure in the treatment of ametropic and anisometropic amblyopia in adults. Adult patients with anisometropic and refractive amblyopia could benefit from the refractive treatment with significant improvement of the visual acuity.
Adult↗
[Adhesion capacity of Enterococcus faecium (SF 68) and Enterococcus faecalis to various substrates].
The author's studied the adherence ability of Enterococcus faecium SF 68 compared to that of Enterococcus faecalis IM 11f, on various substrates: vascular catheters and cardiac valves of rabbit, immunodepressed rats and diabetic rats. The bacterial adherence test was calculated by the number of bacteria adhered for microscopic field enlarged to 2000. The data obtained by scanning electron microscope SEM (Cambridge Stereoscan 150 MK2) revealed a different adherence action of the two germs on the various substrates. All the adherence tests showed a higher and uniform adherence activity of E. faecalis compared to that of E. faecium.
Animals↗
[Effect of spiramycin on the interbacterial aggregation process in dental plaque formation].
The Authors valued on 18 periodontal patients the bleeding, probing depth, plaque indexes before and after antibiotic therapy with spiramycin. After bacteriological test and coaggregation test the Authors concluded spiramycin all day long is endowed with a good activity in periodontal diseases.
Adult↗
[Mixed culture of Enterococcus faecium SF 68 with pathogenic intestinal bacterial strains].
An antagonistic activity of Enterococcus faecium SF 68 towards Plesiomonas shigelloides, Aeromonas sp., enteropathogenic Escherichia coli and Yersinia enterocolitica has been studied and demonstrated.
Aeromonas↗
[Protection of an oral vaccine against experimental infection of mice and its role combined with the administration of penicillin].
The AA. studied the immunologic profile of an oral vaccine to prevent the experimental infection in mice and its effect when it was administered with antibiotic. The mice were infected with Staphylococcus aureus and protected by the vaccine administration. Our results confirmed the higher survival in the group that used this combination. The observed mortality was lower in group of mice treated with vaccine and penicillin combination, than in the untreated group.
Administration, Oral↗
[Immunogenic activity of a polyvalent oral vaccine].
The AA. studied the effects of a polyvalent oral vaccine on the cellular immunity, and on IgA level in animal. They also studied its ability to reactivate the response to the Clostridium tetani toxin in human volunteers. The results show a very good ability of the vaccine as specific and aspecific stimulator.
Administration, Oral↗
[Interference of clindamycin in skin infection in rabbits caused by suture threads infected with slime-producing S. epidermidis].
The authors have carried out an experimental study to evaluate the interference of sub-inhibitory concentrations of clindamycin on the adherence of slime producing S. epidermidis to surgical nets and its ability to infect rabbits. 80 rabbits divided into 4 groups, (A, B, C, and D), underwent sham operation of the abdominal zone and were sewn up with sterile nets, infected nets and sub MIC of clindamycin equal to 1/8 MIC, respectively. The results obtained stressed a different survival rate 12 days after operation: 95% in group A, 35% in group B; 100% in group C and 95% in group D. This data were confirmed by the results obtained using MES (Cambridge Stereosecan 150 KM2). From our research an excellent clindamycin inhibitory activity on the pathogenicity of slime producing staphylococci emerged.
Animals↗
[Role of Enterococcus faecium SF 68 in experimental infection in mice].
The normal intestinal flora is an important defence against various infectious agents. It also allows important metabolic stages in the host. The Authors studied the ability of Enterococcus faecium SF 68 to protect the mice (Swiss strain) from infection by Salmonella typhi and its role when used with penicillin in infection by Staphylococcus aureus. Our results showed that SF 68, determined a good protection against infection. Moreover the association E. faecium SF 68-antibiotic lowers the mortality rate in the infected mice compared with the control group.
Animals↗
[Bactericidal and potent antiadhesive activity of sulbenicillin].
Sulbenicillin, a wide broad spectrum penicillin, is active against a lot of gram positive and gram negative bacteria. The AA. studied the activity of this molecule against urinary infections causing germs, by evaluating two parameters: his antiadhesive capability and the Killing curves, in comparison with mezlocillin and piperacillin. An inhibition in adhesive capability of test-germs, due to sulbenicillin was obtained. Furthermore, resulting Killing curves showed more rapidity in action for sulbenicillin than for the two others molecules, versus resistant germs, like P. aeruginosa and S. faecalis.
Bacterial Adhesion↗
[The intestinal ecosystem of mice after administration of a polyvalent oral vaccine].
Bacterial antigens orally administered, have been showed by many Authors capable to stimulate immunity system, hinding thus the pathogen flora from gut-colonization. Founding on these findings, AA. of the present paper intend to point out by collected microbial data and M.E.S. photos, the activity of an oral polyvalent vaccine made by lysates strains of E.coli, enterococci, staphylococci and P.vulgaris, on normal intestinal flora of mice contemporaneously administered with a pathogenic strain of Salmonella enteritidis. Vaccine showed himself to be able enough to limit alterations of intestinal flora due to infection by the pathogens.
Administration, Oral↗
[Protection against experimental infections in mice by an oral vaccine and its combined role when administered with antibiotics].
Immunomodulator with significantly modify the immunologic response of the host. The AA. studied the immunologic profile of an oral vaccine to protect the experimental infection in mice and its effect when it was administered with antibiotics. The mice infected with S. enteritidis were protected by the vaccine administered. Also in the group of mice treated with a vaccine and antibiotic combination, the mortality rate was lower than in the untreated groups.
Administration, Oral↗
In vitro comparative study of RU 28965 against organisms from oral and vaginal flora.
The Authors studied the activity of RU 28965, a new macrolide antibiotic, in comparison whith erytromycin, josamycin, miocamycin, ampicillin and rifampicin against oral streptococci (45 strains), coryneform bacteria (23 strains) and G. vaginalis (15 strains). Minimum inhibitory concentrations (MIC), minimum bactericidal concentrations (MBC) and the effect of inoculum size on MICs were determined. RU 28965 showed better activity than the other macrolides. The MICs of RU 28965 were eightfold higher than the corresponding MICs. The MICs of RU 28965 showed up to 10 fold increase by increasing the inoculum density from 10(3) to 10(7) CFU/ml.
Ampicillin↗
[Immunologic characteristics of a polyvalent vaccine].
A lot of bacterial vaccines show a very interesting immunostimulating profile. The AA. studied the effects of a polyvalent vaccine on the phagocytosis, on the cellular immunity and on the IgA production. They also investigated its capacity to reactivate the response to the C tetani toxin (Booster effect), both "in vitro" and in human volunteers. The results show a significant improvement in the immunity response to specific and aspecific stimuli.
Administration, Oral↗
[A microbiological evaluation of the use of roxithromycin in oral odontogenic infections].
Odontogenic infections are the primary infections caused by indigenous oral bacteria, when a factor changes their perfect equilibrium. We studied 30 samples from patients with odontogenic infections that were submitted to therapy with roxithromycin. Our results showed that 79% of aerobic and 71% of anaerobic bacteria, responsible for odontogenic infections, were sensitive to roxithromycin.
Adolescent↗