Biomedical subjects
Publications and source records attributed to G Clerc.
The authors report two personal cases of a peculiar type of small bowel atresia called "Apple peel small bowel", they give proheminence on the unusualiness of the lesion, the non specific clinical picture, and the relatively bad prognosis. The physiopathologic hypothesis which were proposed for this disease are reviewed.
Open studies with nomifensine the placebo, and double-blind controlled comparisons of nomifensine with placebo, imipramine, amitriptyline, nortriptyline... have been carried out in various parts of the world. Daily dosage varied (50-225 mg), lenght of treatment also (226 weeks). These trials showed considerable effectiveness of nomifensine in neurotic and reactive depressions, it counteracts inhibition and restores drive. Nomifensine caused no significant cardiovascular or anticholinergic side-effects. It does not potentiate the effect of alcohol.
The authors have studied the clinical, electrocardiographic, radiological, phonomechanographic and haemodynamic features of 20 cases of apparently primary pulmonary hypertension of fairly severe degree. An attempt has been made to correlate on the one hand the haemodynamic values, and on the other the clinical findings, ECG signs of right-sided preponderance, the size of the artery to the right lower lobe on X ray, and the phonomechanographic results. Particular importance is given to a discussion on the aetiology. It is recalled that syphilis can be excluded, that it is possible the operate on thromboses, and that bilharzia and the haemoglobinopathies may play a part which is yet to be defined.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
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An eight week old baby who presented with a cholestatic jaundice had a bile plug in the ampulla of Vater. The plug was removal via a transduodenal approach. The bile plug syndrome is a rare cause of extrahepatic biliary cholestasis and is different from the inspissated bile syndrome in which the involvement is predominantly hepatocellular.
The authors have studied 50 records of patients who had presented an acute attack of P. falciparum malaria. Both sexes were equally implied. Young people were predominant. The distribution of cases was about the same in the whole year. The fever decreases on the second day and increases on the third day (300/0). Among the classical signs: relative rarity of hepatomegalia (100/0), splenomegalia (10 0/0), jaundice (140/0), nervous symptoms (100/0). Vomiting is rather frequent (30 0/0). From the cardiovascular point of view a relative bradycardia is observed in 16 0/0 of the cases, and a relative tachycardia in 100/0 of the cases; hypotension in 100/0 of the cases. Electrocardiographic signs are observed in 360/0 of the cases; they are aspecific, concerning mainly ST-T anomalias (22 0/0) and a QT lengthening (200/0). The cardiothoracic ratio is higher than 0.5 in 320/0 of the cases. From the pulmonary point of view the authors have observed symptoms contemporary of the attack: two asthma attacks, three radiologic anomalias reminding of viral pneumopathias. The biological symptoms are mainly transitory functional renal insufficiency in 18 0/0 of the cases. Protection due to AS heterozygosis seems to be confirmed in this study. The efficiency of intravenous quinin treatment is certain.
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