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Biomedical subjects

G Colzani

Publications and source records attributed to G Colzani.

8 recordsLinked to original sources
PubMed1993

[First impressions regarding the use of expandable esophageal prosthesis].

The authors report their views on the treatment of unoperable neoplastic esophago-gastric stenoses with Nitinol prostheses. Despite a number of advantages (reduced trauma, greater tolerability) in relation to plastic prostheses, the paper highlights some problems (difficulty of unfastening, incomplete opening) which may be eliminated by improved materials.

Aged↗
PubMed1988

Enhancement of methotrexate cytotoxicity by modulation of proliferative activity in normal and neoplastic T lymphocytes and in a myeloid leukemia cell line.

Recent advances in the modulation of cell kinetics with growth factors suggest that the effect of cycle-specific cytostatic drugs can be enhanced by combination with such factors. The truth of this hypothesis was investigated by studying the effect of phytohemagglutinin and/or interleukin 2 on the sensitivity to methotrexate (MTX) of normal T lymphocytes and of lymphoblasts of a patient with acute T-cell lymphoid leukemia. In both cases, inhibition of proliferation by MTX was increased from less than 30% in resting cells or those suboptimally stimulated, in the case of leukemic blasts, to 68-83% in maximally stimulated cells. Similar results were observed when the AML 193 human myeloid leukemia line was stimulated with human recombinant granulocyte macrophage colony stimulation factor (GM-CSF). Under basal proliferation conditions, the addition of 1 microgram/ml and 10 micrograms/ml MTX was followed by 48% and 72% inhibition respectively. When 1 ng/ml GM-CSF (40 I.U./ml) was present, these figures rose to 89% and 91%. It is thus clear that growth factor-induced cell proliferation increases sensitivity to cycle-specific cytostatic agents. There is thus a biological premise for new perspectives in antineoplastic therapy.

Cell Division↗
PubMedDate not supplied

[Treatment of postoperative biliary fistulas by endoscopic papillosphincterotomy and nasobiliary drain].

Personal experience in the non-surgical treatment of postoperative biliary fistulas observed between July 1987 and October 1990 is reported. Leakage were treated with an endoscopic technique (papillosphincterotomy+nasobiliary drain) in 11 of 12 patients in an average time of 2 weeks. The 12 patient, who presented a lesion of an intrahepatic duct, needed 2 months to heal following combined endoscopic-percutaneous manoeuvres. On the basis, then, of the good results obtained, it is recommended that in these cases, non-surgical treatment should be carried out on principle, choosing endoscopy as the initial access route.

Biliary Fistula↗
PubMedDate not supplied

Clinical, diagnostic and therapeutic aspects of caecal displacement in calves fed reconstituted milk.

On the basis of a large number of cases the occurrence of displacement of the caecum is reported in calves fed reconstituted milk. This displacement, a classification of which is given, occurs with the movement of the caecum into the left half of the abdomen in contrast to what occurs in animals fed a different diet. After a description of the various clinical and diagnostic aspects, details are given of the surgical technique used for treatment, and an aetiopathogenic hypothesis is formulated to explain the disease process.

Animal Feed↗