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Biomedical subjects

G Cooke

Publications and source records attributed to G Cooke.

33 records · Page 2Linked to original sources
PubMed1978

The effects on polymorphonuclear leucocyte function of prednisolone and azathioprine in vivo and prednisolone, azathioprine and 6-mercaptopurine in vitro.

The effects of prednisolone azathioprine and 6-mercaptopurine on polymorphonuclear neutrophil chemotaxis, phagocytosis, and killing of Staphylococcus aureus and Candida albicans have been studied. In twenty patients with a functioning kidney graft, taking both azathioprine 2.5 mg/kg/day and prednisolone (mean dose 0.59 mg/kg/day; range 0.30-1.0 mg/kg/day), the polymorphonuclear function did not significantly differ from that in either twenty-two normal or eighteen uraemic controls. Addition of prednisolone, 1.2 X 10(-5) M, azathioprine, 2.1 X 10(-5) M, and 6-mercaptopurine, 2.1 X 10(-5) M, using each drug alone, to normal human polymorphonuclear cells in vitro did not significantly alter their function. It is concluded that prednisolone and azathioprine together in vivo and that both these drugs and 6-mercaptopurine singly in vitro have no significant deleterious effect on polymorphonuclear function and do not contribute, in this way, to the increased susceptibility of patients receiving these drugs to infection.

Adolescent↗
PubMed1975

The influence on judges' sentencing practices of a mental evaluation.

Minimum and Maximum sentences were compared for a sample of 347 prison commitments and for 130 of 347 mental evaluation referrals who finally received prison sentences. It was found that referral for evaluation influenced the probability of remaining in the system until sentencing, but for those sentenced, did not influence the sentence imposed. However, the findings of the evaluation did show a tendency to affect the sentence. Individuals who were found incompetent were less likely to remain in the criminal justice system until sentencing. Those individuals who were initially found incompetent and then became competent and were sentenced, and those individuals who, though found competent, were diagnosed schizophrenic, tended to receive shorter sentences. These findings held even when comparisons were controlled for presence of prior convictions. The implication is that the referral for and findings of the mental evaluation, though not officially a part of trial testimony as to intent or responsibility, do in fact influence the probability of a sentence and, if sentenced, the sentence imposed.

Adult↗