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Biomedical subjects

G Corey

Publications and source records attributed to G Corey.

12 recordsLinked to original sources
PubMed1996

Allergic and irritant patch test reactions and atopic disease.

This study presents a profile of patients with chronic recalcitrant eczematous disease referred by dermatologists for contact allergy evaluation. Allergic contact dermatitis (ACD) and irritant responses were carefully defined, as was the presence or absence of atopy obtained by history. Of 410 patients studied, 44% had no history of atopic disease and 46% were classed as definitely atopic. Among relevant ACD patch test reactors (n = 198), 51.5% had atopy, compared with 40.9% with no atopy but this difference was not significant. Likewise, among atopics (n = 189), 54% had definite, relevant ACD patch test responses while 33.9% had negative ACD (again not significant). Significance was seen in the higher mean number of positive allergic patch tests in the atopic group (2.7 versus 2.0, p = 0.0223). Irritant patch tests were highest among patients with both ACD and atopy (p = 0.0308) and the proportion of irritant responses correlated with increasing numbers of positive ACD tests. We conclude that atopics are at least as likely to have ACD as are non-atopics. Irritancy is increased in these patients with chronic dermatitis and the frequency of irritant reactions correlates with both greater numbers of ACD responses and with presence of atopy.

Adolescent↗
PubMed1996

Psoralen plus UVA protocol for Compositae photosensitivity.

BACKGROUND: Patients allergic to sesquiterpene lactones found in Compositae plants may develop severe photosensitivity, which can result in persistent light reaction. Treatment of these exquisitely photosensitive individuals can be very difficult, often requiring hospitalization. Although some treatment regimens have used psoralen plus UVA (PUVA) therapy, no specific outpatient protocol has been established OBJECTIVE: The purpose of this study was to develop an effective PUVA outpatient regimen to treat compositae photosensitivity. METHODS: A prednisone-assisted PUVA protocol was established in which the prednisone does was decreased weekly, and the PUVA dose was increased during the same time interval. RESULTS: Both patients enrolled in the study experienced dramatic improvement in their previously unresponsive eruptions. CONCLUSIONS: Two men aged 66 and 80 years were subjected to this protocol. Both men had chronic photodistributed dermatitis that resolved with this treatment and in one instance has remained clear for 18 months without needing further PUVA therapy.

Aged↗
PubMed1978

The Chilean experience with antipoliomyelitis vaccination.

The classical epidemiological picture of poliomyelitis in Chile completely changed in the 70s after the control programme had been steadily initiated in the early 60s. The technical and administrative approaches developed by the programme are presented. The epidemiological, immunological, managing and cost advantages of oral attenuated polio vaccine have proven in the Chilean experience to be highly efficacious when the vaccine is given to a community on the basis of permanent programmes with sufficient coverage. Different technical and administrative strategies in furnishing polio vaccine and the backing of the health infrastructure of the country have proved to be successful in reducing incidence to zero. The active role of the community, the steady and permanent adjustment of the programme, the integration of vaccination activities to a place of prime importance in local health services and epidemiological surveillance are all considered to be highly important in the results obtained.

Child, Preschool↗
PubMed1978

25 years of an integrated vaccination program in Chile.

Various problems and subjects related to the long Chilean experience in vaccination programmes are reported. Emphasis is placed on proper administrative and planning steps in order to obtain the right epidemiological diagnosis, to develop the infrastructure of health, to support financially, to manage resources, to train personnel, to apply techniques and to evaluate periodically. The advantages of the integration of the programme in primary services are commented on. Epidemiological evaluation and surveillance are considered highly important in the successes obtained. The particular structure of health services in Chile has played a meaningful role in meeting public health requirements for the past 25 years, specifically with respect to vaccination programmes.

Chile↗
PubMed1976

Field trials with killed oral typhoid vaccines.

The article gives the results of the use of two types of killed oral typhus vaccine administered to students 10 to 19 years of age in two urban areas of the Province of Santiago. Vaccine from the German Democratic Republic (GDR) was administered to 37,517 students and placebo to an equivalent control group. The period of observation was 18 months (November 1973-April 1975). The other product, from the German Federal Republic (GFR) was administered to 37,566 students, with placebo given to an equivalent control group. In this case the observation period was 7 months (October 1974-April 1975). The antigenic composition of the two vaccines is qualitatively and quantitatively different as are the characteristics of their preparation. In the field trial with the product from the GDR, the morbidity for typhoid fever in the vaccinated and control groups showed statistically significant differences, even though on the border line level. Satisfactory and highly significant results had been obtained with the product in earlier field trials. The difference observed between morbidity in the two groups in the field trial with GFR vaccine was not significant. It is emphasized in this regard that the observation period was shorter in this case, which precludes definitive conclusions. A high proportion of reliable confirmation of diagnosis of cases is evident for both field trials. The findings show the need for subjecting this type of vaccine to further and better field trials.

Administration, Oral↗
PubMed1975

Tests with three antigens in leprosy-endemic and non-endemic areas.

A study comparing the 48-h and 30-day reactions produced by three antigens was made in areas of low and high leprosy endemicity in Venezuela and in areas of Chile, a non-endemic country. The antigens used for the intradermal tests were standard Mitsuda antigen, supernatant from standard Mitsuda antigen, and PPD. The results indicate that there is no difference in the Mitsuda reaction of persons living in areas of high or low endemicity, but they show a statistically significant difference between the reactions in persons who live in endemic areas and those of persons living in a country where the disease has not been described. The difference in the Fernandez reaction obtained with the supernatant was not statistically significant between the two population groups in the endemic country, but was highly significant when comparing the endemic and the non-endemic countries.

Adolescent↗