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Biomedical subjects

G Coscia

Publications and source records attributed to G Coscia.

9 recordsLinked to original sources
PubMed1997

The determination of dose characteristics of ruthenium ophthalmic applicators using radiochromic film.

Ruthenium ophthalmic applicators are energetic beta ray sources, supplied in several shapes and dimensions, and used in intraocular tumor therapy. Because of their small dimensions, the determination of dosimetric characteristics represents a technical challenge. We developed a semiautomatic method to define surface dose, dose distribution, and percentage depth dose of such applicators using radiochromic dosimetric media. These detectors consist of a thin (7 microns) radiation sensitive layer on polyester base (100 microns total thickness) changing color as a function of radiation exposure. Transmission images of exposed films were then grabbed with a TV-digitizer system to obtain a gray-level image from which dosimetric characteristics such as isodose distribution, dose values, and homogeneity of nuclide distribution were derived. Good agreement between experimental results and Monte Carlo simulation performed using the GEANT 3 code, appear to be a confirmation of the validity of the method. Moreover while manufacturer specifications of absolute and relative dose rates present a standard deviation error of +/- 30% on dose rate and +/- 6% on accuracy of relative dose values, the proposed method reduces the errors to +/- 10% and +/- 4%, respectively.

Beta Particles↗
PubMed1996

Swelling of the floor of the mouth: a clinical dilemma.

Swelling of the floor of the mouth is sometime difficult to diagnose clinically. Lithiasis and neoplasm are the most frequent causes of intraoral swelling. Also after plain radiology and computed tomography the diagnosis is often dubious. A case of swelling of the floor of the mouth due to an adenoid cystic carcinoma of the sublingual gland is reported.

Biopsy, Needle↗
PubMed1994

[Nasal hyperreactivity and work environment].

The Authors report bibliographic data concerning the effects of some substances present in the work environment of the nose and the possibility of nasal hypersensitivity to these substances. Preliminary data referring to a current study in the First ENT Clinic of the University of Turin on workers exposed to formaldehyde vapors are reported.

Formaldehyde↗
PubMed1988

B lymphocyte markers in multiple myeloma and related plasma cell dyscrasias.

Multiple myeloma and benign monoclonal gammopathies are regarded as monoclonal B cell proliferations in which B lymphocyte maturation is blocked in the final stages of the differentiation cycle. "Blocked" cells accumulate in the body and produce large quantities of immunoglobulins. These are monoclonal, because they come from a monoclonal cell stock. This study presents the results of peripheral B lymphocyte and marrow plasma cell typing designed to reveal the postulated isotypical relationship of the proliferating cells and the serum paraprotein. A good, though not absolute correlation between the two immunoglobulins was noted in most patients. The data, however, was not used in the diagnosis and treatment of these diseases. Further studies with MoAb's will, perhaps, provide a finer subclassification of the B lymphocyte proliferation diseases and assist in their diagnosis and treatment.

Antibodies, Monoclonal↗
PubMed1980

[Routine examinations for the evaluation of thrombotic risk].

The objective of our research was to align to the PAT Breddin system other routine analysis. With this procedure we intend to have, further indications on eventual pre-thrombotic situations. We have passed through examination 85 subjects: 30 as negative subjects, 55 as potential positive pre-thrombotic. The 85 subjects were passed through the PAT Breddin analysis system and the biological research of the antithrombin III, the antiplasmin and the dissolution of the coagulum. The result was satisfactory, in order to allow us to verify that utilising more research parameters we will have a more complete picture of the individual thrombosis tendency.

Adult↗
PubMedDate not supplied

[Multiple myeloma and occupational risk factors: a case-control study].

In order to identify possible relationships between multiple myeloma (MM) and occupational factors, a hospital-based case control type study was carried out on 94 cases of MM and on 188 controls matched for sex, age (S.D. = 2 years) and area of residence, suffering from orthopaedic trauma and free of chronic/degenerative or tumoral diseases. All jobs done for at least a year in a period of 5-30 years before diagnosis were considered. Statistical analysis showed a significant correlation between MM and agricultural work (OR 1.82; I.C. 95% 1.03-3.25), which agrees with the data in the literature. The etiopathogenetic hypotheses reported in the literature are discussed and proposals for further research are made.

Age Factors↗