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Biomedical subjects

G Cotrozzi

Publications and source records attributed to G Cotrozzi.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Atmospheric radiations. Effects of potassium-inhibitory and potassium-retentive hormones on two types of infective agent].

The glucocorticoids and the estrogens facilitate the loss of potassium from the cells (iK+ hormones). The thyroid hormones, the androgens, the growth hormone and the insulin facilitate the penetration of potassium into the cells (rK+ hormones). The incretion of iK+ hormones follows the course of the intensity of the atmospheric radiations (atmospheric electric field, terrestrial magnetic field), that is it grows or diminishes according to the increase or decrease of the intensity of said radiations, while the incretion of rK+ hormones has an opposite course in comparison with the variations of said intensity. The iK+ hormones cause loss of iodine, decrease of eosinophils, of RNA and antibodies, while the rK+ hormones cause opposite effects. High temperatures produce an increase of iK+ hormones and low temperatures an increase of rK+ hormones. The study of the effects of atmospheric radiations on infectious diseases has shown the existence of two kind of infectious agents: the iK+ agents and the rK+ agents on which the hormones iK+ and rK+ have an effect. The hormones iK+ work jointly with iK+ agents (virus RNA, bacteria Gram-negative) and counteract the rK+ agents (virus DNA, bacteria Gram-positive, protozoa). The rK+ hormones have opposite effects in comparison to those of iK+ hormones, that is they counteract the iK+ agents and work jointly with the rK+ agents.

Background Radiation↗
PubMed1983

[Oral glucose tolerance test reevaluated in 68 subjects for its validity in growth hormone secretors].

The aim of this research was to establish both the frequency and the amount of the response of pituitary GH secretion to oral glucose load (OGL) in comparison to the usual, insulin and arginine, stimuli. Previous research on this topic was performed using either a limited number of subjects or experimenting throughout too short a period of time. 68 young subjects, 50 males and 18 females, aged 6-17 years, were studied. All 68 subjects underwent three stimuli of pituitary GH secretion: oral glucose and i.v. administered insulin and arginine. Patients were divided, according to our clinical knowledge and that of Tanner and Co. into: 1) responders, characterized by a plasma GH peak greater than 6 ng/ml, following at least one of the three stimuli; 2) non-responders, characterized by a plasma GH peak inferior to 6 ng/ml, following all three stimuli. A positive response was obtained by OGL in 79.68% of subjects, while a positive response was obtained by insulin stimulus in 72.58% and by arginine stimulus in 77.77%. The presence of positive response to OGL is not correlated to the patients age. The amount of the response, i.e. the mean of plasma GH peaks is similar using both OGL (11.92 +/- 8.57 SD) and insulin stimulus (11.75 +/- 7.48 SD). Some patients (8.82%) responded only to OGL stimulus, lacking a response to arginine and insulin stimuli. The authors emphasized the use of OGL because it is devoid of side reactions and because it simultaneously allows an evaluation of both glucose tolerance and insulin secretion capacity.

Adolescent↗
PubMed1982

[Oral glucose tolerance test in polycystic ovary syndrome].

OGTT was used to clarify the problem of hyperinsulinism and insulin resistance previously investigated by us in PCOS, using the tolbutamide test. The results of this latter investigation were in agreement with the previous found by us and with the similar already reported by other Authors. 26 women (7 obese), aged 14-34 years, affected by PCOS, were studied. The diagnosis of PCOS was made using clinical, hormonal, radiologic and echographic criteria. 16 age matched healthy women were used as controls. Glucose and insulin curves, glucose (GA) and insulin (IA) response areas and IA/GA ratio (insulin resistance in dex-IRI-) were studied by OGTT. Blood insulin values of patients resulted significantly more elevated than that of controls at any point of the curve and more significantly elevated were decreasing values. Mean values of insulin peaks, of insulin areas and of IRI resulted more elevated than that of controls. The presence of both an hyperinsulinism and an insulin resistance in PCOS seems therefore evident. A correlation was found between IRI values and plasma testosterone levels in non obese patients with increased urinary 17-ketosteroid output. A relationship between hyperandrogenism on one hand and hyperinsulinism and insulin resistance on the other is suggested.

Adolescent↗
PubMed1982

[Intravenous glucose tolerance test in the polycystic ovary syndrome].

The problem of hyperinsulinism and insulin resistance, previously observed by us in PCOS using the tolbutamide test, was studied in the present research using intravenous glucose tolerance test (IVGTT). 16 women (3 obese) aged 14-34 years, affected by PCOS, were studied. The diagnosis of PCOS was made using clinical, hormonal, radiologic and echographic criteria. 8 age matched healthy women were used as controls. Glucose and insulin curves, glucose (GA) and insulin (IA) response areas and IA/GA ratio (insulin resistance index-IRI-) were studied by IVGTT. Both the mean insulin peak and the mean insulin area were significantly more elevated in patients than in controls. Average IRI value also was significantly higher than that of controls. The presence of both an hyperinsulinism and an insulin resistance is shown by the higher values in patients compared to controls. No correlation was found between either insulin areas or IRI values with plasma testosterone and urinary dehydroisoandrosterone, whereas correlations were demonstrated in previous studies, using OGTT, by us and other Authors and by us using tolbutamide test. The difference in the nature of the various stimuli performed seems to explain the different results.

Adolescent↗
PubMed1982

[Hyperinsulinism and insulin resistance in the polycystic ovary syndrome as tested with tolbutamide].

The aim of this research was to study both insulin secretion and insulin resistance index (IRI) in seventeen females, aged 16-30, affected by polycystic ovarian syndrome. The diagnosis was made using clinical, hormonal, radiological and echographic criteria. Eight healthy women, carefully matched with our patients for age and for statistical obesity incidence, were studied as controls. Both glycemic and insulinemic curves, areas, insulinemic/glycemic area ratio (IRI) were studied by tolbutamide test (1 g i.v.). Areas were assessed by planimeter, blood glucose by Trinder method, blood insulin by a RIA method, statistical study by t Student test and correlation coefficients. These latter were determined by comparing individual plasma testosterone, FSH, LH and LH/FSH ratio values together with urinary total 17-ketosteroid and delta HEA output values on the one hand and insulin areas and IRI values on the other. Increased glycemic areas, insulinemic peaks and areas, associated with markedly increased IRI values, were observed in the patients. A correlation exists between hyperinsulinism, insulin resistance on the one hand and increased urinary androgens output on the other. delta HEA resulted particularly increased over other androgenic fractions.

Adolescent↗
PubMed1980

GH secretion by arginine stimulus: the effect of both low doses and oral arginine administered before standard test.

Small arginine doses (2 ml of 10% - 200 mg - arginine monohydrochloride i.v. administered) are capable of provoking a significant GH secretion. No correlation was found between GH peak observed after this administration and that observed after a standard arginine stimulus (24.8 g) performed subsequently. GH response to a standard arginine stimulus was blunted, differently from the response to insulin stimulus, by a previous oral arginine administration.

Adolescent↗