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Biomedical subjects

G Cserni

Publications and source records attributed to G Cserni.

66 records · Page 4Linked to original sources
PubMed1996

Gastric pathology in Meckel's diverticulum. Review of cases resected between 1965 and 1995.

One hundred forty-nine case files of Meckel's diverticulum resected at our hospital between 1965 and 1995 were reviewed for the presence of heterotopic gastric mucosa. Of these, 140 cases were evaluated, and 25 demonstrated ectopic gastric mucosa. Six of these heterotopic tissue specimens contained no assessable surface mucosa; therefore only 19 were evaluated for gastric histopathologic changes. "Gastritis" was present in all reviewed cases, but the predominant pattern was that of reflux-type gastritis or gastropathy, which had not previously been documented at this location. This gastropathy was demonstrated in 58% of the cases and could also account for some of the symptoms that prompted removal of appendixes without inflammation. Chronic and chronic active gastritis were also demonstrated in a minority of cases, and those with moderate or severe activity were associated with peptic ulceration. No Helicobacter pylori-like organisms were detected with either modified Giemsa stain or hematoxylin-and-cosin (H&E) stain. Findings were inconclusive with regard to erosive gastritis related to nonsteroidal anti-inflammatory drugs in Meckel's diverticulum. That the proportion of ectopic gastric mucosa found in several studies (including this one) is about half that suggested in textbooks indicates a need for a better workup of resected Meckel's diverticulum and a search for all types of gastric disease if gastric heterotopia is present. Emphasis must be placed on identification of reflux-type chemical gastritis and gastropathy, which are often documented as normal mucosa.

Adolescent↗
PubMed1996

Endometrial adenocarcinoma in early pregnancy.

Adenocarcinoma of the endometrium with intrauterine pregnancy is extremely rare. We report the case of a 35-year-old woman with endometrial cancer discovered in the 7th gestational week. A therapeutic abortion was performed and because of bleeding and spotting dilatation and curettage was done 10 days later. Histology revealed adenocarcinoma in addition to products of conception. Hysterectomy and bilateral salpingo-oophorectomy was performed 3 weeks after intracavitary radiotherapy. Because of superficial myometrial infiltration demonstrated microscopically, the patient received intravaginal and external radiation postoperatively. She remains well 1 year after diagnosis.

Abortion, Therapeutic↗
PubMed1995

[Detection of Helicobacter pylori in biopsy specimens, methodical studies].

Demonstration of Helicobacter pylori infection receives more and more importance in nowadays gastroenterological practice. The authors have compared culture and histology from 69 antral biopsy specimens for their ability to document Helicobacter pylori infection. Infection ratios in the context of clinical and histological diagnoses resulted in a distribution pattern similar to that described by others: 85-69% of duodenal ulcer patients, 67-67% of gastric ulcer patients, 62-54% of patients with gastritis and/or erosion(s) and 33-60% of endoscopically negative patients were found to be Helicobacter pylori positive with culture and histology respectively. Normal or atrophic mucosa showed no bacteria with either methods, but one must also consider the small number of such cases in this study. Chronic gastritis with no signs of activity proved to be infected only in a minority of cases, while chronic active gastritis cases were Helicobacter pylori positive in 72 and 61% histologically and with culture respectively. The modified Giemsa stain used in this study grave a relative specificity of 0.74 and sensitivity of 0.79 as compared with culture. There was a good association between the two methods tested, and this could be further improved by doing the two tests simultaneously. The association was weaker when the tests were done asynchronously, this is why it is not recommended to use such a diagnostic schedule. Comparison of the traditional haematoxylin-eosin stain with the modified Giemsa stain resulted in a very strong association between the two.(ABSTRACT TRUNCATED AT 250 WORDS)

Biopsy↗
PubMed1993

Intracranial lipoma of the Sylvian region.

The incidental autopsy finding of an intracranial lipoma in the left Sylvian region is reported. This is a rare location for an uncommon lesion. A recent theory on its pathogenesis as a congenital lesion is presented and current methods of diagnosis and treatment are discussed.

Aged↗
PubMed1990

Brain and core temperatures and peripheral vasomotion during sleep and wakefulness at various ambient temperatures in the rat.

Changes in brain, core and tail skin temperatures (Tbr, Tc and Tt) associated with transitions in the arousal states were recorded in rats throughout the 24-h diurnal cycle at 10 degrees C, 21 degrees C and 29 degrees C. Falling asleep was accompanied by decreases in both Tbr and Tc and vasodilation at 10 degrees C and 21 degrees C. At 29 degrees C, tail vessels were permanently dilated, and further dilation was not found on sleep onset. Tbr and Tc, however, continued to decrease during non-rapid-eye-movement sleep (NREMS); these changes are likely to result from reductions in heat production and increased conductive heat loss. The changes in Tbr, Tc and Tt on awakening mirrored those on falling asleep. It is suggested that the suppression of sleep in the cold and the enhancement of NREMS in the heat promote thermoregulation. Rapid-eye-movement sleep (REMS) was associated with sharp rises in Tbr. The rise in Tbr was the largest in the cold and was attenuated at 29 degrees C. Tc decreased and Tt increased in the cold, whereas Tc tended to increase and Tt to decrease in the heat. The paradoxical peripheral vasomotion during REMS supports previous suggestions on severe thermoregulatory impairment during REMS in other species.

Animals↗
PubMedDate not supplied

Internal mammary lymph nodes and sentinel node biopsy in breast cancer.

The long-term follow-up of patients treated with extended radical mastectomy has proved that the internal mammary node (IMN) status is an important prognosticator of breast cancer. Patients with isolated IMN involvement seem to have the same outcome as those with limited axillary disease, and these patients may therefore be overstaged in the TNM system. Sentinel node biopsy (SNB) of IMNs may be an ideal staging procedure, but lymphatic mapping studies demonstrate that data from extended radical mastectomy series cannot be extrapolated to patients suitable for SNB, where the IMN involvement is <5% overall, and around 1% for IMN metastases without axillary disease. Current evidence does not allow internal mammary SNB to be recommended as a standard procedure, but as patients with IMN involvement may benefit from adjuvant systemic treatment, internal mammary SNB should be further studied in this context.

Breast Neoplasms↗
PubMedDate not supplied

Pitfalls in frozen section interpretation: a retrospective study of palpable breast tumors.

AIMS AND BACKGROUND: The use of frozen sections for purposes of diagnosis is recognized to involve a degree of uncertainty. A retrospective study of breast specimen frozen section diagnoses was undertaken in order to analyse the major pitfalls. METHODS: Hard copy files from our archives relating to symptomatic (palpable) breast specimens obtained between 1983 and 1996 were reviewed. RESULTS: The review revealed 23 errors among the diagnoses on 2110 frozen specimens. Twenty-two of them were false-negative and 1 (a case of multiple intraductal papillomatosis with atypical ductal hyperplasia) was false-positive for malignancy. The factors contributing to the pitfalls were: 1) misinterpretation; 2) poor quality of the frozen sections (artifacts making the diagnosis difficult); 3) sampling errors during sectioning; 4) ignorance of the macroscopic features; 5) lesions difficult to interpret; 6) ductal carcinoma in situ as the only lesion in the specimen; and 7) sections not deep enough. Several of the factors sometimes occurred simultaneously. CONCLUSIONS: Although the number of errors is relatively low, more stress should be placed on the preoperative diagnosis of breast lesions. Breast surgery frozen section should be used as rarely as possible for diagnostic purposes, despite the generally good diagnostic accuracy. However, it is reasonable to use frozen sections widely until the given preoperative diagnostic tools allow an appropriate preoperative workup, because it is the only way to keep histopathologists trained to interpret frozen sections.

Breast Neoplasms↗