Comparative sequencing.
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Financing, Government↗
Biomedical subjects
G Curlin
Publications and source records attributed to G Curlin.
Rotavirus gastroenteritis in the Washington, DC, area: incidence of cases resulting in admission to the hospital.
The incidence of rotavirus gastroenteritis in infants and children that required admission to the hospital was estimated for a defined population of approximately 105,000 individuals, including 29,000 children aged 15 years or younger whose primary health care was provided by Group Health Association, Inc, a health maintenance organization in the Washington, DC, area. From January 1977 through March 1979, almost all infants and children in this age group who required hospitalization for gastroenteritis were studied for evidence of infection with human rotavirus (HRV) and other agents. On the average, one in 272 (3.7/1,000) infants less than 12 months old and one in 451 (2.2/1,000) children aged 13 through 24 months were hospitalized for HRV disease each winter. The incidence of rotavirus gastroenteritis requiring hospitalization declined precipitously in children after the second birthday and such illness was not detected in children aged 5 years or older. The role of other agents in acute gastroenteritis requring hospitalization was minimal, compared with that of rotavirus.
Adolescent↗
Diarrhoeal disease in Bangladesh: epidemiology, mortality averted and costs at a rural treatment centre.
The basic epidemiology of acute diarrhoeal disease seen at a rural Bangladesh hospital in 1975 is reviewed. V. cholerae 01 was isolated from 28% of 1 964 patients. Significant differences in hospitalisation rates were observed between males and females in several age groups. Overall hospital case fatality was 9/1000 cases. We estimate that approximately a quarter to half of the hospitalised patients would have died had no rehydration therapy been available. The region's total mortality was reduced by approximately 7%-15%, at a cost of United States $0.14 per capita. Mortality from acute diarrhoeal diseases was greatly reduced for all age groups, and total mortality and mortality from all diarrhoeal diseases were particularly reduced for young children and young adults. Rehydration therapy used in a field hospital was apparently highly effective in reducing general mortality and mortality from acute diarrhoeal diseases.
Adolescent↗
Enterotoxigenic Escherichia coli and idiopathic diarrhoea in Bangladesh.
Faecal Escherichia coli from Bangalee patients with idiopathic diarrhoea were tested in the Chinese hamster ovary cell (C.H.O.) assay to detect production of thermolabile enterotoxin (L.T.). C.H.O-positive E. coli produce both L.T. and a thermostable toxin (S.T.). C.H.O.-positive strains were found in 19.2% of all cases and in 70% of the most severely ill patients with non-vibrio cholera. E. coli which produce S.T. alone were identified in a third of the C.H.O.-negative cases. Enterotoxigenic E. coli were found in 55% of inpatients with idiopathic diarrhoea and, if an aetiological role is confirmed, may be one of the commonest causes of tropical diarrhoea.
Adolescent↗
Letter: Ampicillin-resistant Shiga bacillus in Bangladesh.
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Ampicillin↗
Cholera toxoid boosts serum Escherichia coli antitoxin in humans.
Sera from individuals vaccinated with a cholera toxoid were tested to determine if sera with significant titers of cholera antitoxin could neutralize Escherichia coli thermolabile enterotoxin. Individuals who responded to immunization with significant increases in serum cholera antitoxin titers also showed increases in serum E. coli enterotoxin-neutralizing capacity. These findings suggested the possibility that the cholera toxoid vaccine may be useful in preventing disease caused by E. coli.
Antitoxins↗