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Biomedical subjects

G D Hart

Publications and source records attributed to G D Hart.

At least 19 recordsLinked to original sources
PubMed1993

Growth and metastasis of human breast carcinomas with Matrigel in athymic mice.

Immunodeficient athymic mice with human tumor xenografts provide an important in vivo experimental model for cancer research. However, only a limited number of tumor types grow in these animals. For human breast carcinomas, the incidence of tumor-take is 6-15%. Recently, increased incidence of xenograft development in mice has been reported for various human tumors when the tumors were coinjected with Matrigel. We studied the development of human breast carcinoma xenografts in athymic mice with and without coinjection of Matrigel. Tumors developed in only 7.3% of enzyme-dispersed tumors injected subcutaneously in saline solution alone. None of these tumors metastasized to distant sites. On the other hand, 50% of enzyme-dispersed tumors coinjected with Matrigel developed xenografts; four out of five of these tumors metastasized to distant sites. Our data from the recent study suggest that, in athymic mice, Matrigel not only enhanced breast tumor growth but also facilitated tumor metastasis.

Animals↗
PubMed1990

Cellular retinol binding protein and breast carcinoma.

Cellular retinol binding protein (C-RBP) levels were measured in 87 malignant and 18 non-malignant breast cancer tissues. C-RBP, sedimenting in the '2S' region on 5-20% sucrose density gradients, was detectable in 70% of malignant tissues examined. None of the non-malignant tissues contained detectable C-RBP. No significant association between tumour steroid receptors status, patients' obesity or menopausal status and C-RBP contents was observed. However, patients with stage IV disease had higher C-RBP levels than patients at stages II and III (P less than 0.0001), which suggested altered intracellular mobilization of retinol in the tumour, probably as an indirect consequence of inadequate nutrient intake.

Breast Neoplasms↗
PubMed1983

Mycobacterium chelonei: report of a case of septicemia and review of the literature.

Mycobacterium chelonei was originally included in group IV of Runyon's classification of "anonymous" or "atypical" mycobacteria. Although a frequent contaminant without clinical significance, this organism has definite pathogenic potential. A compromised host with M. chelonei septicemia and disseminated candidiasis is described. A review of the literature on M. chelonei human infections is also presented.

Alcoholism↗
PubMed1976

Antagonistic action of Streptococcus salivarius and Streptococcus faecalis to Mycobacterium tuberculosis.

Streptococcus salivarius and Streptococcus faecalis were found to inhibit the growth of Mycobacterium tuberculosis on Löwenstein-Jensen and Middlebrook 7H11 agars, but not on the latter medium when antibacterial drugs were added. S. faecalis was found to be more inhibitory than S. salivarius to 15 strains of M. tuberculosis. S. salivarius produced little or no inhibition of growth of Runyon group III organisms but was very antagonistic to Runyon group I mycobacteria.

Agar↗
PubMed1976

The I.V. nurse.

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Hospital Bed Capacity, 500 and over↗
PubMed1971

The Habsburg jaw.

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Consanguinity↗