[Improvement of bacteriological diagnosis of tuberculosis using new nutrient media].
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Bacteriological Techniques↗
Biomedical subjects
G D Ismagulova
Publications and source records attributed to G D Ismagulova.
[Use of ampicillin trihydrate in transplantation surgery].
Ampicillin trihydrate was used for the treatment of 29 patients with purulent inflammatory processes, such as peritonitis, suppurating operative wound, urinary tract infection after the kidney allotransplantation. The antibacterial activity of ampicillin was preliminarily tested on 517 microbial strains, i.e. staphylococci, streptococci, E. coli, Proteus and Ps. aeruginosa isolated from the surgical patients. The strains of penicillin sensitive staphylococci, streptococci and E. coli were most sensitive to the drug effect, the MIC ranging from 0.03 to 16 gamma/ml. It was shown that the blood retention time of the antibiotic was much more prolonged in the patients with a decreased excretion function of the kidneys. The treatment was performed under control of the clinical, bacteriological and biochemical parameters. The drug was used in a dose of 0.5 g 6--8 times a day for 5 to 15 days. A satisfactory therapeutic effect was registered in 73 per cent of the cases.
Adult↗
[Comparative activity of 6 cephalosporin antibiotics against the causative agents of surgical infection].
Activity of 6 cephalosporanic antibiotics, such as cephaloridin, cephalotin, cephradin, cephacetry1, cephamezin and cephalexin was studied on 200 strains of microorganisms causing purulent infections in surgical patients (Staphylococcus, E. coli, Proteus and Ps. aerugionsa, 50 strains of each organism). The studies showed significant differences in the activity of the above antibiotics against definite species of the pathogenes. The highest activity of the cephalosporins was observed with respect to the clinical strains of staphylococci resistant to such drugs as benzylpenicillin, tetracycline, erythromycin, kanamycin, lincomycin. A significant part of the clinical isolates of gramnegative organisms, i.e. E coli and indol-negative Proteus was characterized by sensitivity to cephalosporins. Among the cephalosporins tested cephaloridin was most active against Staphylococcus, cephacetryl and cephaloridin were most active against E. coli. With respect to the indol-negative Proteus no pronounced advantages of the separate drug were noted. All 6 cephalosporins had low activity against the indol-positive strains of Proteus and all strains of Ps. aeruginosa.
Cephacetrile↗
[Some data from studying and using aminoglycoside antibiotics in reconstructive surgery].
Effectiveness of antibacterial drugs from the group of aminoglycoside antibiotics,i.e. kanamycin, gentamycin and tobramycin with respect to the main causative agents of surgical infections, i.e. Staphylococcus, Coli bacteria, Proteus and Ps. aeruginosa was shown. The highest activity against Ps. aeruginosa was registered to tobramycin. The aminoglycoside antibiotics were satisfactorily absorbed after their intramuscular administration providing therapeutic levels of the antibiotics in the blood. For instance, administration of gentamycin in a dose of 80 mg and tobramycin in a dose of 50 mg 1-2 times a day provided the blood levels higher than the minimun inhibitory concentrations for most strains of gramnegative flora including Ps. aeruginosa. The use of the above drugs in theraphy and prophylaxis of infections caused by Ps. aeruginosa is expedient.
Aminoglycosides↗