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Biomedical subjects

G D Roark

Publications and source records attributed to G D Roark.

6 recordsLinked to original sources
PubMed1983

Endoscopic prognosis in gastric cancer.

Sixty-eight patients with gastric adenocarcinoma underwent upper gastrointestinal endoscopy from 1968 to 1975. Tumors were divided into two categories according to their gross characteristics at endoscopy (mass-ulcer or infiltrative), to try to correlate gross morphology and stage at presentation with survival. The median survival in the mass-ulcer group was 31 months, in the infiltrative group, 4.7 months. Mucosal biopsies were positive in 88% of the mass-ulcer group and in 64% of the infiltrative group. Ninety-four percent of patients with infiltrative lesions had stage III or IV disease (regional lymphatic or distant metastasis) at the time of diagnosis, compared to only 55% of the mass-ulcer patients. Endoscopic features consistent with an infiltrating tumor suggest an advanced stage of tumor with a poor prognosis.

Adenocarcinoma↗
PubMed1983

Painful dysphagia from infiltrating oat cell carcinoma.

Oat cell carcinoma of the lung is an aggressive malignancy with a propensity for widespread dissemination. Surprisingly, spread of this tumor to the esophagus from adjacent lung is unusual. Although submucosal involvement has been noted occasionally, overt mucosal ulceration, to our knowledge, has not been demonstrated previously. Two patients with oat cell carcinoma developed painful dysphagia and mucosal ulceration from tumor infiltration into the esophagus.

Carcinoma, Small Cell↗
PubMed1983

Acute upper gastrointestinal bleeding in patients with portal hypertension: a correlation of endoscopic findings with etiology.

Esophagogastric variceal hemorrhage is a common cause of upper gastrointestinal bleeding in patients with portal hypertension. In addition, it is now recognized that patients with alcohol-induced chronic liver disease and portal hypertension frequently bleed from acute mucosal lesions. Since alcohol can cause these lesions in the absence of portal hypertension, we evaluated 28 episodes of upper gastrointestinal hemorrhage in patients with portal hypertension who did not consume alcohol. Varices were the source of blood loss in 86% of our cases, and no bleeding episodes were attributable to acute mucosal lesions. Acute mucosal lesions, therefore, appear to be uncommon causes of bleeding in nonalcoholic patients with portal hypertension.

Acute Disease↗
PubMed1983

Ingested foreign material in mentally disturbed patients.

Advances in endoscopic technology and its enthusiastic clinical application have resulted in the capability of retrieving most ingested foreign objects from the upper gastrointestinal tract. Although endoscopic removal of foreign bodies is generally safe, it is not always clearly indicated. Foreign bodies in the esophagus usually require prompt intervention. In contrast, objects are frequently retained in the gastric lumen for long periods without adverse consequences. Psychotic or demented patients are a major adult group at risk for foreign body ingestion. Because endoscopy in this group often carries additional risks, and since smooth objects are usually well tolerated in the stomach for long periods, we recommend a conservative approach in this circumstance.

Adult↗
PubMed1983

Chlamydia trachomatis in the ascitic fluid of patients with chronic liver disease.

Several recent reports suggest that Chlamydia trachomatis causes peritonitis and perihepatitis in young women. We studied nine patients with chronic liver disease and ascites to determine a possible role for C. trachomatis in the bacterial peritonitis of cirrhotic patients. C. trachomatis was isolated and identified from the peritoneal fluid in three of these patients. In these patients, the peritoneal fluid was a transudate that contained fewer than 250 white blood cells/mm3, with fewer than 10% neutrophils, except when a bacterial organism other than C. trachomatis was also present. Two of these patients developed peritonitis that was associated with other bacterial organisms. Unless specific tests for C. trachomatis was performed, its presence will not be detected, and the peritoneal fluid cell count will not suggest bacterial infection.

Adult↗