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Biomedical subjects

G D Shostka

Publications and source records attributed to G D Shostka.

57 records · Page 4Linked to original sources

[Physico-chemical properties of the blood of patients with chronic kidney failure].

Physico-chemical characteristics of blood from patients with chronic kidney insufficiency were studied by means of ionization equilibrium in whole blood, blood plasma and erythrocytes suspended in physiological solution. The curves of ionization equilibrium were registered by changes of pH under conditions of controlled heating (58 degrees) of blood, blood plasma and erythrocytes. Electric charge of proteins in blood plasma, erythrocytes and, especially, in whole blood was decreased in patients with chronic kidney insufficiency as compared with healthy persons. In the patients with kidney impairment, as distinct from healthy persons increase in ion strength improved the blood physico-chemical properties and an artificial elevation of hematocrit decreased the electric charge of blood and deteriorated the immunological properties of blood plasma proteins.

Acetylcholinesterase↗

[Risk of infection with hepatitis B and C viruses of medical workers, patients in the hemodialysis ward, and vaccine prophylaxis of hepatitis B infection in these populations].

Markers of hepatitis B (HBsAg, anti-HBs) and C (anti-HCV) were detected in 1990-1992 by enzyme immunoassay in 1581 medical workers, 230 last-year students of medical schools, 269 patients hospitalized at hemoperfusion wards, and 701 blood donors. Hepatitis B markers were detected in medical workers two times more frequently than in donors (HBsAg in 4.7 and 2.2% of these, respectively, anti-HBs in 26.2 and 14.0%), and anti-HCV were found almost three times more frequently (in 3.1 and 1.1%, respectively). The incidence of these markers in students of medical schools was the same as in donors. Hepatitis B markers (HBsAg, anti-HBs) were detected in 39.0% of patients of hemoperfusion departments, HBsAg being present in 11.9%, and antiHCV in 25%. A direct relationship was revealed between the incidence of hepatitis B and C markers and duration of treatment at dialysis centers or length of service at therapeutic institutions. Three vaccinations with Engerix B 944 vaccine were administered to 944 medical workers and 162 medical students and four vaccinations in double doses to 40 patients of hemoperfusion centers who had no hepatitis B markers; a month after immunization anti-HBs in protective titers were detected in 91.4, 93.9, and 76.1% of them, respectively, and a year after vaccination these values were 77.2, 82.5, and 53.3%. No cases of hepatitis B, detection of HBsAg, or postvaccination complications in the vaccines were recorded.

Disease Transmission, Infectious↗