Biomedical subjects
Publications and source records attributed to G D Timmons.
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A new case of the cerebro-hepato-renal syndrome is being reported. The neuropathologic changes consisted of developmental abnormalities of cerebral and cerebellar cortex and of the inferior olives. In addition, there were metabolic changes in the central nervous system, indicated by an accumulation of lipid within histiocytes of free in gray and white matter, deficiency in myelination and gliosis of the white matter, and marked proliferation of protoplasmic astrocytes in the gray matter. A unique feature of this case was the presence of numerous clusters of lipid-filled macrophages and occasional cholesterol crystals in the molecular layer of the cerebellum. The histochemical reactions and ultrastructural appearances of the lipid deposits are suggestive of accumulation of several different types of lipids.
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Explore the source record for details and available documents.
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Seventy-five normal (control) children were compared to 15 hyperactive children on a Continuous Performance Test over an eight-week period. The control children were observed to have a relatively constant number of correct responses, chair movements, and reaction times throughout the testing period. However, when the hyperactive children were differentiated according to their scores on the Conner's Abbreviated Parent Questionnaire, those children scoring one standard deviation above the normative mean were later revealed to have more errors of commission and omission, chair movements, and a longer reaction time than did the normal control children.
Errors of commission and omission, chair movements, and reaction times were assessed in fifteen previously diagnosed hyperactive children on a Continuous Performance Test after four drug regimens: amphetamine at doses of 1.6 and 5.0 mg twice a day, as well as 300 mg caffeine administered alone and with 1.6 mg amphetamine twice a day, produced significant reductions in errors of commission and increased reaction times in those children scoring 24 or more on the Conner's Abbreviated Parent Questionnaire. In addition, subjective symptoms on this questionnaire were significantly reduced by all drug treatments. The high (600 mg) daily dose of caffeine was observed to significantly control hyperactive symptoms, however, it also produced a number of side effects as well.