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Biomedical subjects

G D Winter

Publications and source records attributed to G D Winter.

17 recordsLinked to original sources
PubMed1978

Wound healing.

Explore the source record for details and available documents.

Humans↗
PubMed1976

Experimentally induced steroid atrophy in the domestic pig and man.

A histological method of ranking topical steroid preparations according to the degree of epidermal thinning they cause in pig skin has been shown to be applicable to human skin. A 0-05% ointment of the new compound, clobetasone butyrate (Molivate), has been shown to cause less thinning than either fluocinolone acetonide 0-025% (Synalar) or flurandrenolone 0-0125% (Haelan) when applied without the use of occlusive dressings for 3 weeks to the human forearm.

Adult↗
PubMed1976

The effect of clobetasone butyrate and other topical steroids on skin thickness of the domestic pig.

A new glucocorticoid, clobetasone butyrate, has been shown in patients to have good topical anti-inflammatory activity and a minimal effect on hypothalamic-pituitary-adrenal function. Among a group of topically active corticosteroids, compared in a controlled study in the domestic pig, clobetasone butyrate is shown to cause less epidermal thinning than any of the others except only 1% hydrocortisone. This evidence of a lesser atrophogenic effect may indicate further dissociation of unwanted from wanted properties in clobetasone butyrate.

Administration, Topical↗
PubMed1975

Clinical considerations in the choice of materials for orthopedic internal prostheses.

The six principal clinical considerations which influence the choice of materials for total joint replacements are given. The necessity for screening tests on potentially useful materials is stressed. These should be carried out on specimens which have been exposed to the sterilizing process, which will be used in clinical practice. The materials should also be investigated after immersion in a physiological solution-bovine serum; following implantation in a large animal. Useful tests are impact testing, and wear studies using pin-on-disk and journal and bush specimens. In the case of total joint replacements, equipment in which joint motions and loadings can be simulated can provide valuable information. The components should also be subject to fatigue testing. There is a need to develop agreed laboratory methods for testing of materials and implants and for the long term follow up of patients.

Animals↗
PubMedDate not supplied

Evaluation of the polypropylene braid as a prosthetic anterior cruciate ligament replacement in the dog.

The purpose of this scientific investigation, made prior to 1977, was to determine the suitability of a polypropylene prosthetic ACL. The 3.6 mm diamond-braided prosthesis was implanted in 17 dogs. The device was passed through a trough on the anteromedial side of the tibial crest and over the top of the lateral femoral condyle. The device was internally fixed at both ends to bone using a bushing-lag screw technique which resulted in solid prosthesis immobilization at the time of surgery. Animals were necropsied at 3, 6, or 10 months after implantation. There was partial or total disruption of the prosthesis in all cases. Destruction of the prosthesis was attributed to excessive viscoelasticity of the device and fatigue failure. Based on this study, prosthetic ACL replacement using this device is not recommended.

Animals↗