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Biomedical subjects

G D Zarubeĭ

Publications and source records attributed to G D Zarubeĭ.

16 recordsLinked to original sources
PubMed1987

[Experience in the treatment of eye tumors using a narrow medical proton beam].

This paper presents the effects of proton beam therapy of 175 patients with tumors of the eye. Irradiation was performed with a narrow medical proton beam (Institute of Theoretical and Experimental Physics) with the energy of 70 MeV (Bragg's peak). The total dose was 6000-7000 rad, irradiation frequency was 5-6 sessions every other day. Irradiation was used to treat intraocular and orbital melanomas, melanomas an cancer lesions of the eyelid and conjunctiva. According to the WHO classification, tumors fell under the T2-T3N0M0 stage. The follow-up periods varied from 1 to 10 years (an average of 3.4 years). Complete tumor regression was observed in 45% of the cases, partial regression in 39%, and the absence of the effect in 16%. Twenty-two patients (12%) underwent enucleation due to progressive tumor growth (16 patients) or postradiation complications (6 patients). Hematogenous metastases within a period of 2-5 years following irradiation were noted in 4% of the cases. The results obtained indicated a high efficacy of proton beam therapy for large ocular tumors. The mortality rate from metastases following irradiation was lower than that following enucleation.

Adult↗
PubMedDate not supplied

[The concept of ophthalmologic oncology development].

The authors review the research results concerning the diagnosis and treatment of ocular tumors over 25 years of activities of Department of Ophthalmooncology and Radiology and analyze the perspective trends for future studies.

Eye Neoplasms↗
PubMedDate not supplied

[Postradiation secondary glaucoma and prevention measures].

The authors have examined the possibility of preventing the development of secondary glaucoma after eye irradiation with a narrow medicinal proton beam. Twenty-eight patients with cilio-choroidal melanoma were involved in the study, 7 male and 21 female ones, aged 48.4 on an average. The authors' findings evidence that postradiation changes in the anterior segment of the eye, resulting from radiation iridocyclitis, are mainly responsible for the development of secondary glaucoma. Preliminary laser-effected formation of iridal coloboma is conducive to a normal flow in the anterior chamber at the expense of an additional pupil functioning and thus helps reduce the possibility of secondary glaucoma development by 1.6 times (or by 38.5%).

Adult↗
PubMedDate not supplied

[Validation of the use of brachytherapy in uveal melanomas of juxtapapillary localization].

Forty-two patients with juxtacapillary melanomas of the choroid were treated by brachytherapy. The treatment was carried out in two stages: Stage I--separating laser coagulation, Stage II--irradiation with ophthalmologic applicators (90Sr, 90I). Complete resorption was achieved in 12 patients, partial regression with the process stabilization in 17, no effect in 13, in 11 of these enucleation had to be performed. The mean follow-up period has made up 6.8 years. Analysis of brachytherapy results has lead the authors to a conclusion that this treatment modality may be considered as enucleation alternative in patients with juxtacapillary melanomas located by the optic disk and covering not more than 1/3 of its perimeter, with the prominence of less than 3 mm; brachytherapy applicator in this case should be US monitored.

Brachytherapy↗
PubMedDate not supplied

[Metastatic involvement of liver in patients with uveal melanoma].

The efficacy of enucleation and brachitherapy is assessed in 1150 patients. The incidence of metastases is the highest (up to 2/3) occurs within the first 3 years. Neither enucleation, nor brachitherapy affect this value. However, in general after enucleation the incidence of metastases to the liver (31.7%) is higher than after brachitherapy (5.8%), this indicating that brachitherapy is more effective in minor and medium-sized melanomas of the choroid.

Brachytherapy↗