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Biomedical subjects

G Dörner

Publications and source records attributed to G Dörner.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Conservative therapy of prostate cancer using Turisteron].

Turisteron is an orally highly effective depot estrogen (ethinylestradiol sulfonate) with relatively slight side effects. The treatment with Turisteron is very effective and is well tolerated by the patient. A strong antiandrogenic effect could be produced which had as its sequel a significant increase of the survival rates of patients with carcinoma of the prostate gland. The weekly dosage of 2 mg Turisteron led to a decrease of the biologically active, free testosterone to less than 2% compared with the initial value. The decrease of the total testosterone to castration values and the decrease of the free testosterone still significantly below values of castration are evidences for the strong antiandrogenic effect in exclusive estrogen treatment with Turisteron. From this conclusions relevant to practice were derived and finally therapy recommendation for the conservative treatment of the carcinoma of the prostate gland were given.

Aged↗
PubMed1987

[Behavior of LH, FSH, total testosterone, free testosterone and SHBG serum levels in the therapy of prostatic cancer with Turisteron (ethinyl estradiol sulfonate)].

45 patients with prostatic cancer were treated conservatively with Turisteron at a dosage of 2 mg per week. After 2 months the serum levels of total testosterone were reduced to castration values and thereafter furthermore to 6% of the pretreatment values. The free testosterone (FT) serum level did show a decrease to 2%, while the binding capacity of the sexual hormone binding globulin (SHBG) was increased from 4,1% to 97,9%. The serum levels of the two gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were decreased only to nearly 20% of the pretreatment value. The investigations confirm the definite "antiandrogenic" effect of Turisteron, which is 10-times higher than the antigonadotropic effect.

Ethinyl Estradiol↗
PubMed1987

[Vesicle population of synapses in the hippocampus of the rat following early postnatal deprivation and administration of pyridostigmine].

Newborn male Wistar rats were subjected to early postnatal social and nutritional deprivation by separation of the pups from their mother animals from Day 3 to Day 14 for 16 hours daily. One group of the deprived animals was treated by daily injections of pyridostigmine (1 microgram/0.05 ml saline from Day 1 to Day 4, 5 micrograms/0.05 ml saline from Day 5 to Day 14). At the age of 14 days or 6 months, 5 deprived, 5 deprived and pyridostigmine treated rats and 5 controls were investigated. In the stratum radiatum of the hippocampal CA 1-region the vesicle population of axospinodendritic synapses was examined for quantitative ultrastructural changes using electron microscopic and morphometric methods. The vesicle density (number of vesicles/micron 2 terminal area) was determined in the whole presynaptic terminal as well as in distinct zones in the presynaptic terminal. 14 days of deprivation did not change the vesicle density in the whole presynaptic terminal, but did change the distribution of the vesicles. In 14 days old deprived rats the vesicle density was found to be decreased by about 10% in the presynaptic area bordering the synaptic contact zone (area 1), and it was increased by about 7% in the more distant area of the presynaptic terminal (area 2). Deprivation and simultaneous pyridostigmine treatment resulted in an elevated vesicle density in the whole presynaptic terminal by about 25%, in area 1 by about 8%, and in area 2 by about 30%. At the age of 6 months, the early postnatally deprived rats showed an increase in the vesicle density by about 8% in all areas of the presynaptic terminal when compared with the controls. Simultaneous pyridostigmine treatment led to a reduced vesicle density in the whole presynaptic terminal by about 5%, in area 1 by about 9%, and in area 2 by about 4%. The findings obtained following deprivation are interpreted as being the expression of an insufficient requirement of synaptic mechanisms caused by a lack of sensoric inputs during the early postnatal period. The results obtained in the neonatally pyridostigmine treated rats suggest permanent changes in the neurotransmitter metabolism following treatment with the psychotrophic drug. This may reflect a mechanism to compensate the effect of deprivation by neonatal pyridostigmine administration.

Animals↗
PubMed1987

[Clinical study of ethinyl estradiol sulfonate in conservative therapy of prostate cancer].

Ethinylestradiol sulfonate is an orally applicable, potent depot estrogen with steroid structure. With a dosage of 2 mg per week it shows a distinct antigonadotropic and antiandrogenic effect. Its suitability for the hormone therapy of the carcinoma of the prostate is clinically and cytologically confirmed. It seldom has undesirable side effects. The oral application necessary only once a week guarantees a continuous supply of active substances with a good compliance by the patients.

Adenocarcinoma↗
PubMed1987

[Inhibition of the free, biologically active testosterone level by Turisteron in patients with prostate cancer].

Apart from their antigonadotropic effect oestrogens also directly inhibit the androgen secretion of the testicles. Thus, on the 20th day of treatment the LH-level after 12 g diethylstilbestrol diphosphate (DSDP) decreases only to approximately 50% of the initial value, while the whole testosterone (T), however, is reduced to less than 5%. The sexual hormone binding globulin is significantly more increased (p less than 0.001) by the estrogen treatment than after orchidectomy only. Therefore, the free, biologically active T-level in the plasma consists of more than one third of the level after exclusive orchidectomy. The treatment with the depot estrogen Turisteron is clarly superior to the usual treatment Oestrasid implants. Both with and without orchidectomy the free testosterone level is significantly lower than after Oestrasid implants plus orchidectomy. Therefore, this therapy can successfully be used in the treatment of the carcinoma of the prostate also without orchidectomy.

Administration, Oral↗
PubMed1986

Effects of neuroleptics administered to lactating rats on the behavioral development of offspring.

Effects of diazepam (DZP) and haloperidol (HAL) given to nursing mothers from the day after delivery to weaning on the behavioral development of their pups were investigated. Weight gain in the pups of mothers that received these drugs did not differ from that in the control pups. Male and female pups exposed to HAL through the milk showed an increase of aggressive behavior (attacking and pinning play) when examined within the social unit of the colony at 4 weeks of age. Although an age-related decrease in this play was observed in the pups of all groups at 7 weeks of age, HAL exposed male and female pups or DZP exposed female pups showed this play more frequently than control pups. At 5 weeks of age, male and female pups exposed to DZP or HAL showed an increase in central ambulation of open-field, in spite of no change in total ambulation. Female pups exposed to DZP or HAL showed an increase of rearing. Female pups exposed to DZP or HAL took more time to reach the goal and made more errors in the maze test at 13-15 weeks of age. Male pups exposed to DZP or HAL showed a decrease in the number of complete mounts. Female pups exposed to DZP or HAL showed a decrease in the number of complete lordoses and an increase in the number of defensive behavior. These results indicate that neuroleptics administered to the dams appear to modify the functioning development of the brain in their offspring.

Animals↗
PubMed1986

Behavioural changes in adult rats produced by early postnatal maternal deprivation and treatment with choline chloride.

Rats deprived temporarily of maternal contact and nutrition from the 3rd to 14th day of life showed decreased emotionality and poor memory capacity when tested in adulthood. Simultaneous administration of choline chloride, an acetylcholine precursor, in neonatal life permanently increased the emotionality and restored memory capacity to levels of control animals. However, no effect was demonstrated when choline chloride administration occurred after the deprivation period. The results of this study reveal that the effects on later behaviour appear to be dependent on the timing of choline chloride exposure in early life. Profound and long-lasting abnormalities in brain function produced by early postnatal maternal deprivation can be attenuated by correcting abnormal acetylcholine levels during brain development. Hence, acetylcholine can be considered as an important, environment-dependent local organizer of the brain.

Acetylcholine↗
PubMed1986

[Experimental studies of the significance and mechanism of desensitization to the gonadotropin-inhibiting effect of estrogen. 2. Detection and mechanisms of preovulatory desensitization in the ovarian cycle].

It has recently been demonstrated in women and several mammalian species that the basal LH secretion increases prior to the ovulation-inducing LH surge in spite of a simultaneous rise of the estrogen level in the blood. The temporary relative inefficiency of estrogen in its negative feedback action may be necessary to make adequate gonadotrophic support of final preovulatory follicle maturation possible. To study the mechanisms underlying this phenomenon, the gonadotrophic response to a single injection of estradiol benzoate (EB) was evaluated in acutely ovariectomized adult rats during the different stages of a 4-day ovarian cycle. The results showed that the sensitivity to the gonadotrophin-inhibiting effect of EB is high during late estrus and early metestrus. Between metestrus and diestrus it suddenly declines, and EB did not inhibit the hypophysial gonadotrophin secretion from diestrus through the morning of the subsequent estrus. The cyclic variation of the sensitivity to the negative estrogen feedback is probably not based upon an endogenous rhythm that is independent of the ovarian hormone secretion, because similar variability of the gonadotrophic response to estrogen was not found in rats that had been castrated three days before the injection of EB. A further experiment demonstrated that bilateral implants of EB placed in the medial preoptic area (MPOA) of ovariectomized rats significantly reduced the gonadotrophin-inhibiting effect of s. c. injected estradiol, whereas similar implants located in the mediobasal hypothalamus were completely ineffective in this regard. Since bilateral lesioning of the MPOA in long-term ovariectomized females also lowered the sensitivity to estrogen, the conclusion may be drawn that preovulatory desensitization to the negative estrogen feedback is probably induced in cyclic female rats by an inhibitory effect on medial preoptic neurones of the increase of circulating estrogen recorded in metestrus. In accordance with this assumption, imitation of the periovulatory diminution of estrogen action on the MPOA of intact rats by the removal of medial preoptic EB implants in castrated females during the afternoon of proestrus, resulted in high sensitivity to estrogen during estrus and metestrus. The possible clinical significance of the hitherto not described preovulatory desensitization is briefly discussed.

Animals↗
PubMed1986

[Breast feeding and early postnatal weight gain in Potsdam].

Nutrition and weight gain during the first trimenon of life of 400 babies (200 boys and 200 girls) born in 1975-1977 or 1979-1980 were compared with those of 600 babies (300 boys and 300 girls) born in 1982-1984. The following results were obtained: 1. In 1975-1977 only 10.8%, but in 1979-1980 23.1% and 1982-1984 33.6% of the babies have been breast-fed for more than 6 weeks. 2. In 1975-1977 16% of the babies showed a weight gain of more than 3.0 kg during the first trimenon of life, whereas in 1979-1980 only 8.5% and 1982-1984 only 2.2% displayed such a high weight gain. The average weight gain during the first trimenon was 2.75 +/- 0.55 kg in 1975-1977 and 2.30 +/- 0.61 kg in 1979-1980 and 2.43 +/- 0.35 kg in 1982-1984. 3. The percentage of babies with a weight gain of more than 3 kg during the first trimenon of life was significantly lower in those who were predominantly breast-fed than in those who where predominantly bottle-fed during this period (4.7% versus 9.7%). Hence breast feeding appears to be the best preventive therapy of an early developmental obesity.

Body Weight↗
PubMed1986

[Effect of early postnatal social and nutritional deprivation and simultaneous treatment with pyridostigmine on synaptogenesis in the hippocampus of the rat. Electron microscopy, morphometric and stereologic studies].

During the first two weeks of life newborn male Wistar rats were subjected to social and nutritional deprivation. One group of the deprived animals was treated by daily injections of pyridostigmine (1 microgram/0.05 ml saline from Day 1 to Day 4, 5 micrograms/0.05 ml saline from Day 5 to Day 14). At the age of 14 days or 6 months, 5 deprived, 5 deprived and pyridostigmine treated animals and 5 controls were sacrificed by perfusion. The stratum radiatum of the hippocampal CA1-region was investigated for quantitative ultrastructural changes using electron microscopic, morphometric and stereologic methods. The following results were obtained: The number of synapses per unit area or per unit volume brain tissue (hippocampus) was found to be reduced by about 10% in 14 days old deprived as well as in deprived and pyridostigmine treated rats in comparison to the controls. At the age of 6 months both groups of the experimental animals showed an increase in the density of synapses by about 20% when compared to the controls. The proportion of axo-spinodendritic synapses in the total number of synapses (axo-dendritic and axo-spinodendritic synapses) was decreased on Day 14 and was increased at the age of 6 months in the neonatally deprived rats. Following additional pyridostigmine treatment, both in the juvenile and in the adult rats the ratio of axo-spinodendritic to axo-dendritic synapses was approximated to that of the controls. The calculation of the volume of all presynaptic terminals or all postsynaptic spines per unit volume brain tissue (volume density) revealed a decrease by about 6% (terminals) or 5% (spines) on Day 14 after deprivation and an increase by about 8% (terminals) or 14% (spines) following simultaneous pyridostigmine administration. At the age of 6 months the presynaptic terminals in early postnatally deprived rats showed a higher volume density by about 14%. In the deprived and pyridostigmine treated animals volume density enhancements were obtained for the terminals (by about 7%) and for the spines (by about 25%). The volume and surface of an individual presynaptic terminal were unchanged in 14 days old as well as in 6 months old deprived rats in comparison to the controls. Deprivation and simultaneous pyridostigmine treatment led to an increase in the volume (by about 25%) and the surface (by about 12%) of the terminals on Day 14. However, at the age of 6 months the volume and surface were reduced by about 14% or 12% when compared to the controls.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗