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Biomedical subjects

G Dahlberg

Publications and source records attributed to G Dahlberg.

8 recordsLinked to original sources

Resorbable cement for the augmentation of internally-fixed unstable trochanteric fractures. A prospective, randomised multicentre study.

We undertook a multicentre, prospective study of a series of 112 unstable trochanteric fractures in order to evaluate if internal fixation with a sliding screw device combined with augmentation using a calcium phosphate degradable cement (Norian SRS) could improve the clinical, functional and radiological outcome when compared with fractures treated with a sliding screw device alone. Pain, activities of daily living, health status (SF-36), the strength of the hip abductor muscles and radiological outcome were analysed. Six weeks after surgery, the patients in the augmented group had significantly lower global and functional pain scores (p < 0.003), less pain after walking 50 feet (p < 0.01), and a better return to the activities of daily living (p < 0.05). At follow-up at six weeks and six months, those in the augmented group showed a significant improvement compared with the control group in the SF-36 score. No other significant differences were found between the groups. We conclude that augmentation with calcium phosphate cement in unstable trochanteric fractures provides a modest reduction in pain and a slight improvement in the quality of life during the course of healing when compared with conventional fixation with a sliding screw device alone.

Activities of Daily Living↗

Postoperative migration of the osteotomy segment stabilized by titanium miniplate osteosynthesis following Le Fort I osteotomy: an x-ray stereometric study.

The aim of the present study was to evaluate whether titanium miniplate fixation prevents postoperative migration of the osteotomy segment following Le Fort I osteotomy and, if not, to evaluate whether postoperative migration varies with the direction and amount of surgical repositioning. In 10 consecutive patients who received Le Fort I osteotomies, postoperative migration of the osteotomy segment was studied in a three-dimensional system by means of x-ray stereometry. Surgical repositioning was recorded by cephalometry in lateral head films obtained before surgery and at 2 days postoperatively. X-ray stereograms were obtained at intervals from 2 days to 1 year after surgery. During the 1-year observation period, significant postoperative migration of the osteotomy segment was found at some stage in nine patients. No correlation between the amount of surgical repositioning and postoperative migration was found. However, a tendency toward superiorly directed postoperative migration of the osteotomy segment, independent of the direction of surgical repositioning, was observed. It is thus concluded that titanium miniplates do not prevent postoperative migration of the osteotomy segment. The weak correlation between the amount of surgical repositioning and postoperative migration of the osteotomy segment indicates that predictions of individual outcomes of surgical corrections are uncertain.

Adolescent↗

Disk displacement and temporomandibular joint symptoms in orthognathic surgery patients.

The purpose of this study was to document the prevalence of disk displacement and temporomandibular joint symptoms in orthognathic surgery patients. Fifty-three consecutive patients with different types of dentofacial anomalies were examined clinically and with bilateral arthrography. Disk displacement unilaterally or bilaterally was found in 57% of the patients or 46% of the joints. Displacement with reduction was seen in 38 joints, and displacement without reduction was seen in 11 joints. Fifty-three percent of the patients had pain in the temporomandibular joint or masticatory muscles, 30% of the joints demonstrated clicking, and 4% had crepitation. No association was found between disk displacement and clinical symptoms except for an association between clicking and anterior disk displacement with reduction. Neither could an association between disk displacement and the type of dentofacial anomaly be appreciated. It was concluded that disk displacement was frequent in patients with dentofacial anomalies, but no relationship to temporomandibular joint symptoms and the type of dentofacial anomaly could be clearly demonstrated.

Adolescent↗

Osseous and muscular changes after vertical ramus osteotomy. A magnetic resonance imaging study.

Magnetic resonance (MR) imaging was performed about 2 years after vertical ramus osteotomy of 10 patients to study changes in the mandibular condyle, cortical and cancellous bone of the proximal fragment, and muscles of mastication. MR imaging observations of the surgically treated patients were compared with findings in 10 asymptomatic untreated control subjects. The results showed that the MR appearance of bone marrow of the mandibular condyle was normal in all patients and in all control subjects. No MR evidence of avascular necrosis of the mandibular condyle was found. MR imaging artifacts from microscopic metallic particles were seen in all surgically treated regions. Thickening of the buccal and lingual cortical bone with narrowing of the bone marrow space was seen bilaterally in eight patients and unilaterally in two patients. Slight medial tipping of the mandibular condyle was seen unilaterally in two patients. Atrophic changes with decreased muscle volume and fatty replacement of muscle tissue was seen unilaterally in eight patients. None of these alterations were seen in the control subjects. MR imaging appears to be an excellent method to study morphologic changes of the muscles of mastication and osseous fragments after orthognathic surgery of the mandible. Thickening of the cortical bone and narrowing of the bone marrow space of the proximal fragment was frequently seen after vertical ramus osteotomy of the mandible and most likely represents remodeling associated with normal healing.

Adolescent↗

Subcutaneous low-dose epoetin beta for the avoidance of transfusion in patients scheduled for elective surgery not eligible for autologous blood donation.

This randomized, multicentre, parallel-group study assessed the efficacy of epoetin beta in reducing the transfusion frequency in patients ineligible for autologous blood donation prior to surgery. The patients (n = 194) received either epoetin beta (125 or 250 IU/kg, once weekly) or no therapy for 3-4 weeks before surgery. The pre-operation haemoglobin levels were markedly increased in the epoetin beta groups (125 IU/kg: +1.1 g/dl; 250 IU/kg: +1.6 g/dl), but not in the control group. The transfusion frequency was significantly reduced in both epoetin groups as compared with the control group (p = 0.046). Epoetin beta was well tolerated, and no serious adverse events were observed. Low-dose administration of epoetin beta before elective surgery reduces the transfusion frequencies in patients not eligible for autologous blood donation.

Blood Transfusion↗