Biomedical subjects

G Dalén

Publications and source records attributed to G Dalén.

6 recordsLinked to original sources

PubMed1986

Long-term changes in inhalant allergy in asthmatic children.

In a representative cohort of 55 asthmatic schoolchildren the progress of the allergy per se was followed up prospectively for 8 years. Judged by clinical data, skin prick tests and RAST, a large majority of the children retained their allergies to pollen and animal danders. These allergens were predominant, whereas allergy to mites and moulds was less frequent. Serum IgE levels showed a strong tendency to remain high. Positive RAST and skin prick tests were also found in a substantial number of children with normal serum IgE concentrations.

Adolescent↗

PubMed1983

MMEF or FEV1 in estimating bronchial obstruction in asthmatic children.

In this study the maximal mid-expiratory flow (MMEF) was compared with forced expiratory volume in 1 sec (FEV1) by a spirometric investigation of healthy children and children with slight bronchial obstruction. We found that the reproducibility of MMEF was good in both healthy and asthmatic children and that both methods had the same ability to detect abnormality before inhalation of a beta 2-receptor agonist. After such an inhalation the discriminatory power was greater for FEV1 than for MMEF and we therefore prefer FEV1 in estimating bronchial obstruction in children.

Administration, Intranasal↗

PubMed1982

Evaluation of two spirometers and two flowmeters in asthmatic children.

The reliability of a Monaghan (M 403) spirometer and a Vitalograph spirometer was evaluated in 46 children with "subclinical" asthma. As in previous studies of healthy children the vital capacity (VC) and the forced expiratory volume in one second (FEV1.0) were close to those of a Bernstein spirometer. The sensitivity of the spirometers and of two flowmeters (Wright's peak flow meter and Airflometer-Glaxo) was evaluated in the asthmatic children after inhalation of salbutamol and the changes after inhalation were compared to those obtained in a previous study of healthy children. The "simple" equipment gave substantial information about the degree of bronchial obstruction. It is concluded that the additional information obtained by using simple pulmonary function tests form a good basis for aggressive therapy.

Adolescent↗

PubMed1979

Assessment of lung function on healthy children using an electronic spirometer and an air-flowmeter before and after inhalation of an adrenergic receptor stimulant.

VC measured with a Monaghan electronic spirometer equipped with a backflow valve is significantly lower (about 4%) than when measured with the same spirometer without such a valve. The measurements of FEV1.0 were not influenced by the valve. 73 healthy children were investigated with the Monaghan spirometer equipped with the backflow valve and normal reference data were established. The results were very similar to those obtained in an investigation of healthy children with the same spirometer about one year earlier. Reference data on children for a simple flow meter, Airflometer (Glaxo Ltd.), are given. The data correlated very highly to the FEV1.0 values obtained by the Monaghan spirometer. After inhalation of salbutamol healthy children had a small and significant increase of FEV1.0 and of the Airflometer value but not of VC. The deviations of the differences were small. A 6% increase of VC and 10% increase of FEV1.0 were taken as normal upper limits after inhalation of salbutamol. Corresponding increase of the Airflometer values was 15 arbitrary units for children with body heights 116--145 cm and 21 units for children with body heights 146--175 cm.

Adolescent↗

PubMed1979

Peak expiratory flow rate. Reference values for Swedish children.

Reference values for the peak expiratory flow rate assessed by the Wright-McKerrow peak flow meter have been established for Swedish children. The material consisted of 143 boys and 132 girls. We recommend the sexes be considered together. The equation of the regression line is 72.14 x height3 + 96.12. The coefficient of correlation is 0.93 and the residual standard deviation 13.7%.

Body Height↗

PubMed1978

Evaluation of three spirometers on healthy children.

Two electronic spirometers (Dräger Spirotron and Monaghan M403) and one wedge bellows spirometer (Vitalograph) were compared with a Bernstein spirometer. Healthy children, 30 girls and 31 boys, were investigated. The regression lines of VC and FEV1.0 in relation to the body height to the third power are very close and the S.D. values around the lines are very similar. The correlation coefficients of the regression lines are high for all the spirometers. An analysis of the paired differences showed slight differences of the mean values. The S.D. of paired differences was for VC 4.6--6.6% and for FEV1.0 4.8--6.2%. The PEFR values obtained by the two electronic spirometers deviated substantially and highly significantly from the values obtained by the Wright peak flow meter.

Adolescent↗