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G David Batty

Publications and source records attributed to G David Batty.

36 records · Page 2Linked to original sources
PubMed2005

Adult socioeconomic position and the association between height and coronary heart disease mortality: findings from 33 years of follow-up in the Whitehall Study.

In the Whitehall Study, which followed 17,139 male civil servants over 33 years, the association between tall stature and coronary heart disease (CHD) mortality differed between employment grades. In men without CHD at study entry, the hazard ratio per 15-cm increase in height was 0.77 (95% confidence interval [CI]=0.69, 0.85; P<0.001) for the highest grades, but 0.84 (95% CI=0.69, 1.03; P=.10) for middle and 0.95 (95% CI=0.75, 1.20; P=.65) for low grades, suggesting that childhood and adult social conditions may interact in their influence on coronary risk.

Adult↗
PubMed2005

Childhood socioeconomic position, educational attainment, and adult cardiovascular risk factors: the Aberdeen children of the 1950s cohort study.

OBJECTIVES: We assessed the associations of childhood socioeconomic position with cardiovascular disease risk factors (smoking, binge alcohol drinking, and being overweight) and examined the roles of educational attainment and cognitive functioning in these associations. METHODS: Data were derived from a cohort study involving 7184 individuals who were born in Aberdeen, Scotland, between 1950 and 1956; had detailed records on perinatal characteristics, childhood anthropometry, and cognitive functioning; and responded to a mailed questionnaire when they were aged 45 to 52 years. RESULTS: Strong graded associations existed between social class at birth and smoking, binge drinking, and being overweight. Adjustment for educational attainment completely attenuated these associations. However, after control for adult social class, adult income and other potential confounding or mediating factors, some association remained. CONCLUSIONS: Educational attainment is an important mediating factor in the relation between socioeconomic adversity in childhood and smoking, binge drinking, and being overweight in adulthood.

Cardiovascular Diseases↗
PubMed2004

Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study.

OBJECTIVE: While several studies have reported on the relation of diabetes status with pancreatic cancer risk, the predictive value of this disorder for other malignancies is unclear. METHODS: The Whitehall study, a 25 year follow-up for mortality experience of 18,006 men with data on post-challenge blood glucose and self-reported diabetes, allowed us to address these issues. RESULTS: There were 2158 cancer deaths at follow-up. Of the 15 cancer outcomes, diabetes status was positively associated with mortality from carcinoma of the pancreas and liver, while the relationship with lung cancer was inverse, after controlling for a range of potential covariates and mediators which included obesity and socioeconomic position. After excluding deaths occurring in the first 10 years of follow-up to examine the effect of reverse causality, the magnitude of the relationships for carcinoma of the pancreas and lung was little altered, while for liver cancer it was markedly attenuated. CONCLUSIONS: In the present study, diabetes status was related to pancreatic, liver, and lung cancer risk. Cohorts with serially collected data on blood glucose and covariates are required to further examine this area.

Blood Glucose↗
PubMed2004

The Aberdeen Children of the 1950s cohort study: background, methods and follow-up information on a new resource for the study of life course and intergenerational influences on health.

In this paper we introduce and describe in detail an addition to the UK's population-based resources for the investigation of biological and social influences on health across the life course and between generations: the Aberdeen Children of the 1950s study. We also provide an account of postwar Aberdeen when study members were growing up, report on findings of analyses of data from the original survey on which this study is based and its follow-up, assess the strengths and limitations of the study, and outline current and future research directions. This cohort comprises individuals born in Aberdeen, Scotland (UK) between 1950 and 1956, and is derived from 15 thousand subjects who took part in the Aberdeen Child Development Survey, a cross-sectional study of 'mental subnormality' (learning disability) in a population of all children who were attending Aberdeen primary schools in December 1962. Data collection included information on birthweight, gestational age, childhood height and weight, tests of cognition and behavioural disorder, and a range of multilevel socio-economic indicators. In 1998 we began the process of revitalising this cohort (now termed the Aberdeen Children of the 1950s study). We have been successful in ascertaining the current vital status and whereabouts of 98.5% of a target population of 12 150 subjects (6276 males, 5874 females) with full baseline data. The large majority (81%) of study participants still reside in Scotland and many (73%) have remained in the Grampian region which incorporates Aberdeen. At the present time, a total of almost 500 subjects are known to have died. Linkages to hospital admissions and other health endpoints captured through the Scottish Morbidity Records system have been completed. This includes an intergenerational linkage to approximately eight thousand deliveries in Scotland occurring to female members of the study population. A postal questionnaire to all traced surviving cohort members has also been distributed.

Child↗
PubMed2004

Revitalising the Metropolit 1953 Danish male birth cohort: background, aims and design.

Recent research indicates that factors operating during childhood are related to adult health. Thus, longitudinal studies with information on subsequent phases may be key to understanding later health outcomes. The main objective of this paper is to describe the history and design of a Danish birth cohort, and its revitalisation. In 1965, information from birth certificates for 11 591 of a total of 12 270 males born in 1953 in the Metropolitan area of Copenhagen, Denmark were traced. These boys were the study population of a sociological investigation conducted with the aim of describing social mobility. At age 12 years, 9537 of these cohort members completed a questionnaire in school, which included cognitive measures and information on social aspirations and leisure time activities. In 1966 educational performance tests were administered for these boys and, in 1968, mothers of 2890 cohort members were interviewed regarding family social backgrounds. With the establishment of the Civil Registration System (CRS) in 1968, it was possible to identify 11 532 cohort members. In 2002 we began the process of revitalising this study with the aim of investigating the influence of early life factors on later health. We succeeded in ascertaining the vital status of all subjects in the CRS. This showed that 863 subjects had died between 1968 and 2002. Linkages to the Register of Causes of Death, the National Hospital Register, Psychiatric Central Register and Danish Cancer Registry have been completed. In total, 7969 cohort members had been hospitalised for any somatic illness and, according to the Psychiatric Central Register, 1382 men had been admitted to a psychiatric hospital or ward. In the Cancer Registry we found 363 of our study participants. Analyses exploring the influence of social conditions in early life, birth dimensions, and childhood cognition on adult health experience are at various stages of completion. A questionnaire-based postal follow-up survey is planned. Thus, the Metropolit study provides an important opportunity to examine the processes by which factors that operate over the life course influence adult health.

Birth Weight↗
PubMed2003

Leisure time physical activity and coronary heart disease mortality in men symptomatic or asymptomatic for ischaemia: evidence from the Whitehall study.

BACKGROUND: Although numerous studies have shown an association between physical activity and coronary heart disease (CHD) mortality in healthy persons, few have reported on this relation in individuals with pre-existing diseases, such as ischaemia. Further, we are unaware of any study to examine if this relationship is modified by the symptomatic nature of the ischaemia. METHODS: To explore these issues, we analysed data from a 25 year follow-up of mortality for 6474 male British civil servants who underwent a resting electrocardiogram and responded to queries regarding angina at study entry. RESULTS: Among men who had ECG abnormalities but no angina (i.e. asymptomatic), activity was associated with a higher rate of CHD mortality. Among men with both angina and ECG abnormalities (i.e. symptomatic), activity was associated with lower CHD mortality but this was not statistically significant at conventional levels. CONCLUSIONS: In the present study, there was a suggestion that the symptomatic nature of ischaemia appeared to modify the effect of physical activity on total and CHD mortality. Although these findings should be examined in other studies, they point to the need for a pre-participation medical examination in active persons or those contemplating embarking on an activity programme.

Adult↗
PubMed2003

Leisure time physical activity and disease-specific mortality among men with chronic bronchitis: evidence from the Whitehall study.

OBJECTIVES: This study examined the association between leisure time physical activity and cause-specific mortality among male Whitehall Study participants with chronic bronchitis. METHODS: Rate ratios were calculated for 4 mortality outcomes, according to level of activity and baseline bronchitis status, in a 25-year follow-up of 6479 men. RESULTS: After multiple adjustment for potential confounding or mediating variables, activity was inversely related to all-cause, cardiovascular, coronary heart disease, and noncardiovascular mortality among men free of chronic bronchitis. Among men with bronchitis, weak, nonsignificant positive associations were observed between activity and these outcomes, with the exception of noncardiovascular mortality. CONCLUSIONS: The suggestion of a positive activity-mortality association among individuals with chronic bronchitis-albeit weak and nonsignificant-requires further investigation.

Bronchitis, Chronic↗
PubMed2002

Physical activity and coronary heart disease in older adults. A systematic review of epidemiological studies.

BACKGROUND: While there is good evidence to suggest an inverse relation of physical activity and cardiorespiratory fitness with coronary heart disease (CHD) in middle-aged men and women, much less is known about this association in older adults. The purpose of this paper was to explore the relation of physical activity and cardiorespiratory fitness with CHD in older adults by reviewing relevant studies. METHODS: Publications were identified in two ways: i) conducting a PUBMED search from its inception in 1966 until January 2001; and ii) scrutinizing the reference sections of identified papers. RESULTS: Ten studies relating physical activity and two relating cardiorespiratory fitness in older people to CHD met the inclusion criteria. With one exception, the studies were observational in nature and the majority of these were of prospective cohort design. Most studies featured men only. Of the eleven studies that presented data on older men, eight reported an inverse relation between physical activity or cardiorespiratory fitness and CHD, and statistical significance was seen in five of these. There were too few data on older women to draw clear conclusions regarding the association in this group. CONCLUSIONS: This review suggests that, in older adult men, physical activity and cardiorespiratory fitness are inversely related to CHD risk. This association is unlikely to be attributable to reverse causality or confounding. Except where such advice is contraindicated, older adult men may benefit from physical activity in terms of reduced CHD risk.

Aged↗
PubMed2002

Socio-economic position and coronary heart disease risk factors in children and young people. Evidence from UK epidemiological studies.

BACKGROUND: Coronary heart disease (CHD) is a condition with its origin in early life. In adults, CHD and its risk factors show clear socio-economic gradients. The aim of the present review is to collate published evidence to assess if these risk factor gradients are also apparent in young people in the UK. METHODS: Pertinent publications were identified in four ways: i) a systematic search of PUBMED from its inception in January 1966 until October 2000; ii) scanning the reference sections of identified publications; iii) searching the authors' own files; and iv) contacting experts in the field. RESULTS: Of eleven CHD risk factors, consistent evidence concerning the association in child- and early adulthood with socio-economic position was evident for cigarette smoking, birth weight, adiposity (in young adults), height, and some aspects of diet, particularly fat and fibre consumption. As in UK adults, the most favourable levels of these risk factors were seen in young people from socially advantaged backgrounds. For the other variables associated with CHD--physical inactivity/low cardiorespiratory fitness, blood pressure, blood cholesterol, adiposity (in children), and some emerging risk factors (C-reactive protein, homocysteine, fibrinogen)--there was little evidence of any clear association with socio-economic level. CONCLUSIONS: While social variation is seen in some CHD risk factors in young people, further data are needed to fully explore if this is also the case for others. This issue could be addressed by analysing some existing but unutilized survey data from the UK.

Adolescent↗