Biomedical subjects

G De Anda

Publications and source records attributed to G De Anda.

15 recordsLinked to original sources

PubMed1997

Localized myofibroblastic proliferation in the neck of a patient with an IgG myeloma.

We describe a myofibroblastic proliferation in the neck and lower part of the face involving skin and muscle of a 68-year-old female patient with an IgG kappa myeloma. Biopsies showed a fusocellular proliferation with scarce pseudoganglion cells involving the superficial fascia and the cutaneous muscle of the neck. The proliferative cells showed immunohistochemical and ultrastructural features characteristic of myofibrobasts with a proliferating cell nuclear antigen index of 48%; 42% of the cells displayed HLADR-positive membrane staining. Cellular proliferation subsided following the use of immunosuppressive drugs. Eight months after initial consultation, the patient developed polymyositis without a proliferative component and died of aplastic anemia.

Aged↗

PubMed1984

[Congenital cutis laxa].

A case of connatal flabby skin or generalized dermatochalasia without genetical familial background is presented. The cutaneous clinic is striking to which pulmonary emphysema with overcharge of the right heart is added. By optical and electronic microscopy the characters of elastic fibers are studied which show diminished with orceing with a normal microfibrilar component lacking the amorphous element or elastine with the electronic microscope. The formation of the dense normal element also appears compromized .

Cardiomegaly↗

PubMed1984

[Change in the turnover of HLA ABC molecules in circulating T lymphocytes in mycosis fungoides].

The turnover of HLA ABC molecules at T and B lymphocyte surface was analyzed in five cases with mycosis fungoides and six healthy controls. The patients had only skin lesions and are staged from T1 to T3 and No, Bo and Mo. The turnover was analyzed by mean of the decrease of the lysis by complement on sensitisized cells with anti HLA ABC antibodies that were incubated for progressive times at 37 degrees C. The results show a largest turnover for the HLA ABC molecules all T cells surface from mycosis fungoides that was significant (PWilcoxon less than 0.01). The turnover of B cells surface was not different from mycosis fungoide and healthy controls. The observed phenomenon was not specific for mycosis fungoide or T cells because previously has been shown in others lympho-proliferative and autoimmune diseases. The authors suggest that the analyzed T lymphocyte, morphologically normal is functionally altered and the behavious could be a metabolic phenotypic marker for the T cell before his coming at skin lesions.

Adult↗

PubMed1984

[Increase of circulating HLA DR+ T lymphocytes in psoriasis].

HLA DR molecules on the surface of T lymphocytes evidences the immune cell activation. In the course of disease with immunopathogenic mechanisms and after immunostimulation the level of peripheral T HLA DR+ lymphocytes increases. In psoriasis, it was previously demonstrated the existence of T HLA DR+ lymphocytes in the skin lesions. This phenomenon suggests an in situ activation of T cells. In this paper we show an increase of circulating T HLA DR+ lymphocytes in 12 patients with active psoriasis (5.81% +/- 3.17) compared to healthy controls (2.02% +/- 0.47). The difference was significative (P less than 0.01). The authors suggest the systemic activation of T cells in psoriasis that could be controlled by the HLA system.

Adult↗

PubMed1984

Familial spastic ataxia associated with Ehlers-Danlos syndrome with platelet dysfunction.

Four members of a family with consanguineous relationships, the proband and his three children (2 sons and 1 daughter) are affected with Familial Spastic Ataxia and with Ehlers-Danlos' Syndrome with platelet aggregation dysfunction. In the four cases, this exceptional association appears remarkably homogeneous both in clinical and laboratory studies. The two syndromes are of dominant-autosomic transmission and probably originated in a new mutation which presumably maintained a genetic linkage. Spastic ataxia is characterized by a precocious onset and a slow evolution. The first-born son shows a dominant pyramidal syndrome with mild ataxia suggesting that it is a transitional form of familial spastic paraplegia. The Ehlers-Danlos syndrome pertains to form II or "mitis" with moderate skin hyperelasticity and joint hypermobility. The abnormal platelet aggregation curves have the same profile in all the patients. The first-born son also presents a mitral valve prolapsus as we may find either in Ehlers-Danlos syndrome or in spastic ataxia. The neurophysiological, tomographical, histological, ultrastructural and biochemical studies attempt to accomplish a better definition of these associated nosological entities.

Adolescent↗

PubMed1983

[Curly hair nevus].

A nevus of the hair follicle of the hair scalp is described on a male child, aged three, white race, with curly hair "curly Hair nevus" and an epidermic nevus of the neck epidermis. The hair are thin, fair, disposed in curls with big spire in a number of two or three. They are short, without a 180 degrees torsion on their longitudinal axis. Transversally cut the section is almost circular. The nosology is discussed and the differential diagnosis is tried with the "woolly hair nevus".

Child, Preschool↗

PubMed1968