Biomedical subjects

G Delisle

Publications and source records attributed to G Delisle.

18 recordsLinked to original sources

PubMed2001

Characterization of oxalate oxidase and cell death in Al-sensitive and tolerant wheat roots.

Several genes including oxalate oxidase (Oxo) are up-regulated in Triticum aestivum L. root tips exposed to Al. To better understand the function of Oxo during Al exposure, the protein level and enzyme activity were measured. The data indicate that both Oxo protein and activity are increased proportionally to the level of root growth inhibition (RGI). A high level of Oxo expression may result in excess H(2)O(2) production which could become toxic and induce cell death. However, the timing of H(2)O(2) production (observed after 24 h) indicates that it cannot be the primary cause of cell death first observed after 8 h. Moreover, at Al concentrations resulting in 50% RGI, we did not observe any cell death in the sensitive cultivar while a punctated pattern of death involving small groups of cells was found in the tolerant cultivar. This pattern was maintained for several days in the tolerant cultivar, suggesting the involvement of a cell death mechanism aimed at replacing epidermal cells intoxicated with Al while root growth is maintained. The accelerated epidermal cell turnover may represent a new detoxification mechanism helping to protect deeper cell layers of the meristematic and elongation zone essential for root growth.

Aluminum↗

PubMed1995

Lobectomy in the treatment of the scimitar syndrome.

The scimitar syndrome is a congenital anomaly that consists mainly of total or partial anomalous venous drainage of the right lung to the inferior vena cava. We report the case of an 8-year-old girl diagnosed at birth as having a scimitar syndrome and who presented with recurrent right lower lung infections. She underwent resection of the lower half of her right lung without diversion of the anomalous venous drainage of the upper portion of the lung. She improved rapidly postoperatively and the shunt fraction diminished.

Child↗

PubMed1986

[Congestive cardiomyopathies in children. Natural history and studies].

Congestive cardiomyopathies represent a group of diseases having in common an intrinsic abnormality of the myocardial contraction, of which the cause often remains unknown. In children, there is a more marked incidence during the first year of life. At the Cardiology Institute of Quebec, 25 patients have been diagnosed with a congestive cardiomyopathy since January 1967. The mortality remains high at 48 per cent, and the morbidity at 28 per cent. Thus, the chance of total survival at 16 years was 33 percent. The evaluation and the treatment of the cardiac function as well as the search for a specific etiology must be carried out because the etiological treatment is sometimes possible. Biopsy of the skeletal muscle as the study of fatty acids metabolism have become very important since the identification of a carnitine deficiency. On the other hand, biopsy of the endomyocardium remains the only means to make a pathological diagnosis. Since the treatment of persisting myocarditis is feasible, the histological diagnosis is a pre-requisite in children. So, in four patients with congestive cardiomyopathy, biopsy of the endocardium has enabled to demonstrate a chronic inflammation of the myocardium in one patient. In three other cases, two had non specific lesions on histological examination an one had an extensive fibro-elastosis. As the symptomatic treatment is often deceiving, an in-depth investigation is mandatory in a child suffering from a congestive cardiomyopathy in order to identify an etiology. Such an approach will enable to apply a specific treatment, to achieve a better understanding and perhaps modify its natural history.

Adolescent↗

PubMed1985

[Paroxysmal junctional reciprocal tachycardia and fetoplacental anasarca].

Foeto-placental anasarca was diagnosed at 34 weeks gestation in a patient with acute hydramnios. Foetal tachycardia at 300 bpm was recorded. This obstetrical problem led to the birth of a premature baby with generalised oedema, for which the only apparent cause was the tachycardia. This was identified as a paroxysmal junctional reciprocating tachycardia, initiating on atrial extrasystolic echos, terminating on R waves, with lengthening of the PR interval at the onset of tachycardia, without acceleration of the sinus rate and P'R = RP'. Paroxysmal junctional reciprocating tachycardia in utero was responsible for congestive cardiac failure and foeto-placental anasarca. The cardiac failure was treated by foetal delivery, artificial respiration and digoxin. The association of digoxin-disopyramide reduces the frequency of attacks of tachycardia and treatment may be stopped after one year's follow-up.

Edema↗

PubMed1984

[Geometric and dynamic characteristics of hockey sticks in regard to their performance].

The hockey stick can be used for numerous tasks such as shooting, dribbling, receiving and executing passes, stick handling, etc. The purpose of this study was to evaluate the geometrical and dynamic characteristics of hockey sticks in order to identify those which contribute most significantly to its longevity and durability. The characteristics of 14 models of hockey sticks were measured according to the procedure describes by Roy and Doré (1975). To evaluate the longevity of the stick, 45 Midget AA were selected. Each one was given two sample sticks selected randomly. They were to use those sticks in practices and in game situations. Fifteen adult players were selected to evaluate the durability of the stick. Each one received four sample sticks. They had to execute as many slap shots as they could until the stick broke. This work confirmed a previous study of Roy and Doré 1975) which demonstrated a high level of homogeneity in the geometrical characteristics, but a high heterogeneity in their dynamic characteristics. This study revealed also that the longevity and durability measures showed a high level of variability. Through a multiple regression analysis, it was shown that the width and thickness of the handle as well as the rupture coefficient and the module of rigidity of the handle (in a plane parallel to the blade) were four variables contributing significantly to the longevity of the stick.

Adolescent↗

PubMed1976

Total anomalous pulmonary venous connection: Report of 93 autopsied cases with emphasis on diagnostic and surgical considerations.

Total anomalous pulmonary venous connection (TAPVC) is failure of development of the common pulmonary vein, with consequent ersistence and enlargement of embryonic collaterals between the lungs and the systemic veins. In the great majority (91 of 93 autopsied cases, 97 per cent, no remnant of the common pulmonary vein was found, supporting the concept of agenesis or involution of the common pulmonary vein. Occasionally, a cordlike strand was found in the location of the common pulmonary vein (in three of 93 cases, 3 per cent), supporting the concept of atresia of the common pulmonry vein. The order of frequency of the various types of TAPVC was: left innominate vein ("snowman"), 26 perent cent; subdiaphragmatic, 24 per cent; coronary sinus, 18 per cent; right superior vena cava, 15 per cent; right atrium, 8 percent; mixed, 5 per cent; azygos, 2 per cent; and left supeior vena cava, 2 per cent...

Adolescent↗

PubMed1975

[Study of tetralogy of Fallot by echocardiography].

Twelve patients with a Fallot's tetralogy proved by a haemodynamic and angiographic examination were studied by echography, a non invasive technique. The diameters of the right and left ventricles, of the left atrium and of the aorta were measured. The movements of the interventricular septum and the position of the aorta in relation to it were analysed. Moreover, by scanning of the left ventricle an opening was looked for in the septum. The ventricular septal defect together with a dilatation of the right ventricle and a more or less intense dilatation of the root of the aorta were found in all cases. In 10 cases, an aorta overriding the septum was observed, and this was the more obvious the older the child. In the two post-operative cases studied, the septum was found to be in line with the aorta. There are therefore echocardiographic criteria making it possible to diagnose Fallot's tetralogy. These criteria are the more obvious the older the child.

Child, Preschool↗

PubMed1974