Biomedical subjects

G Den Otter

Publications and source records attributed to G Den Otter.

9 recordsLinked to original sources

PubMed1985

Scintigraphic studies to evaluate stability of ceramics (hydroxyapatite) in bone replacement.

In this study, the suitability of a radionuclide bone imaging technique was examined in cases of hydroxyapatite implants for segmental replacements of long bones. The radionuclide bone imaging technique, using [99mTc]MDP was applied to estimate osseous changes at the sites of the hydroxyapatite implants up to 2 yr after their implantation in an animal experimental model. The results were correlated with histological and radiographical findings at the same time. The radionuclide bone imaging with technetium proved to be a useful method to estimate the intensity of osseous changes after bone replacement by a hydroxyapatite implant. It proved to be more sensitive than radiography. The differences in elasticity of the implanted material and adjacent bone may cause an increase of radionuclide uptake at the site of the implant 2 yr after implantation. These osseous changes cannot be detected by standard histological and radiographical methods but could be detected by radionuclide bone imaging. It is submitted that the radionuclide bone imaging is a noninvasive, sensitive, and useful method for the estimation of osseous changes in sites of long term bone implants.

Animals↗

PubMed1984

Surgical treatment of pseudocysts of the pancreas--guidelines for management.

From 1968 to 1983 123 patients were admitted with a diagnosis of pancreatitis; in 28 patients a pseudocyst developed. To evaluate results of surgical therapy a study of the literature and a chart review were performed. From this study we conclude that asymptomatic patients with a pseudocyst of 4 cm or less in diameter can initially be treated expectantly. If the pseudocyst is larger than 4 cm in diameter and in those cases where the cyst shows no tendency to spontaneous resolution, operative intervention seems mandatory. If no complications occur, surgery is postponed until six weeks' observation to allow maturation of the cyst and facilitate cystenteric anastomosis. In pseudocysts related to blunt abdominal trauma, endoscopic retrograde cholangiopancreatography (ERCP) should be performed. If ERCP reveals a major duct lesion, resection should be considered.

Adolescent↗

PubMed1984

The treatment of complete rectal prolapse by transabdominal posterior rectopexy.

Fourteen patients with complete rectal prolapse underwent transabdominal posterior rectopexy using a double peritoneal sling fixation technique. Symptoms, sphincter function assessment and a description of the operative technique are reported. Except for one small mucosal prolapse there were no recurrences. The results of our technique are encouraging.

Aged↗

PubMed1982

The Hartmann procedure.

During a 10-year period, 59 patients had a Hartmann operation for diverticular disease (n = 19), carcinoma (n = 21), anastomotic disruption (n = 5), injury (n = 3) and various other conditions (n = 11). Twenty-two patients (37.3 per cent) died postoperatively. Wound infection or wound dehiscence occurred in 26 patients. Other complications inherent in this operation were colostomy necrosis or retraction (n = 12) and leakage of the rectal stump (n = 3). The mean hospital stay of the surviving patients was 28.4 days. Colorectal continuity was subsequently restored in 12 patients (32.4 per cent) and no difficulties were encountered with this procedure.

Adult↗

PubMed1982

Rupture of the diaphragm due to blunt trauma.

From 1968 to 1980 we have treated 21 patients with a rupture of the diaphragm due to blunt trauma. The diagnosis was generally made in the acute phase. Right-sided rupture in this series accounted for 24% of cases. This figure differs significantly from the 10% incidence mentioned in the literature. In our opinion right-sided rupture, especially in patients with multiple injuries, is often overlooked.

Adult↗

PubMed1981

Artificial ventilation with PEEP; the influence on cardiac output in the simulated normo-, hypo- and hypervolemic state.

Observations of the influence of artificial ventilation with PEEP on cardiac output are unequivocal. Not only the measure of the end-expiratory pressure and lung compliance play a role, but also the circulating blood volume. In healthy laboratory animals a state of normo-, hypo- and hypervolemia was simulated by changes in position in neurolept-anesthesia. In all cases artificial ventilation with PEEP induced a decrease of cardiac output as a consequence of a decrease of stroke volume. These results are discussed. The conclusion is drawn that a change in stroke volume during artificial ventilation with PEEP is not only dependent on the level of end-expiratory pressure and pulmonary compliance but also on that portion of the Starling curve where the heart at that instant is functioning.

Animals↗

PubMed1980

Surgical treatment of gastric stump carcinoma.

From 1965 to 1976 134 patients with gastric stump carcinoma were treated. Twenty-nine patients underwent a curative resection. The postoperative mortality was 8 patients; 14 patients survived 3 years. These statistics do not differ significantly from those obtained in primary gastric carcinoma. Twenty-nine patients underwent a palliative resection. The mean survival time was 8.2 month. This survival does not differ from that obtained by other palliative procedures. From the survival time alone one cannot conclude that a palliative resection is preferable to other procedures. Gastric stump carcinoma does not differ essentially from gastric carcinoma and it should be considered as the most important life threatening postoperative complication of partial gastrectomy. On account of the changed anatomical status a total gastrectomy in gastric stump carcinoma is 'the treatment of choice.'

Adenocarcinoma↗

PubMed1978

Aneurysm of internal mammary artery.

A fusiform non-sclerotic aneurysm of the left internal mammary artery was found in an otherwise healthy young woman. Aneurysms such as this seem to be extremely rare since no published case could be found.

Adult↗

PubMed1977

Intermittent jaundice: a rare complication of a solitary nonparasitic liver cyst.

A case of a solitary nonparasitic liver cyst, presenting with intermittent jaundice, is described in a 61-year-old female. Twice during the condition's 19-month course deep jaundice developed, spontaneously subsiding to a state of mild icterus. Diagnosis was suggested by ultrasonography and scintigraphy, whereas retrograde cholangiography and arteriography did not contribute. At laparotomy a single large benign multilocular cyst was partially removed.

Cholestasis↗