PubMed Health⌕ Search

Biomedical subjects

G DiBenedetto

Publications and source records attributed to G DiBenedetto.

7 recordsLinked to original sources
PubMed1991

Wound management with N-carboxybutyl chitosan.

In patients undergoing plastic surgery, donor sites were treated with soft pads of freeze-dried N-carboxybutyl chitosan to promote ordered tissue regeneration. Compared to control donor sites, better histoarchitectural order, better vascularization and the absence of inflammatory cells were observed at the dermal level, whilst fewer aspects of proliferation of the malpighian layer were reported at the epidermal level. Accordingly, N-carboxybutyl chitosan leads to formation of regularly organized cutaneous tissue and reduces anomalous healing.

Adult↗
PubMed1985

Case-finding for unsuspected thyroid disease: costs and health benefits.

An algorithmic test strategy was used in 5,002 hospital and clinic patients to detect unsuspected thyroid disease. The strategy eliminated redundant secondary tests; only 9.4% of patients required a T3 uptake determination and 2.7% a TSH or T3. Twenty-six cases of hypothyroidism (incidence: 0.5%) and seven cases of hyperthyroidism (incidence: 0.1%) were diagnosed. Costs of laboratory tests were analyzed in relation to health benefits. Fully allocated production and induced costs, after discounting to present value, amounted to $31,061. Health benefits were computed using a measure of quality of life derived from health status indices. Sensitivity analysis of selected patient groups demonstrated cost-effectiveness ratios ranging from $2,022 to $1,739 per quality adjusted life year.

Adult↗
PubMed1981

Continuous-flow enzyme immunoassay for thyroxine in serum.

We have evaluated a fully automated thyroxine assay involving the use of a homogeneous enzyme assay and a Technicon AutoAnalyzer II continuous flow system. Comparison by regression analysis with a thyroxine radioimmunoassay kit method gave a slope of 0.82 and a y-intercept of 7.81 micrograms/L (SE 0.86 microgram/L, r = 0.95). Within-run precision yielded CVs of 1.0-6.1%, between-day CVs were 2.0-14.4%; within-day precision showed a mean variance of 7.81 micrograms/L. Mean analytical recovery was 96.1%. Bilirubin, hemoglobin, and lipemia interfered with quantitation of results when their concentrations exceeded 50 mg/L, 300 mg/L, and 5 g/L, respectively. The reference interval for euthyroid status was calculated to be 50-110 micrograms/L. Sensitivity was 5.0 micrograms/L with a mean carryover of 1.65%. Current reagent and labor costs for enzyme immunoassay ($0.40) were less than for the manual radioimmunoassay procedure ($0.40) were less than for the manual radioimmunoassay procedure ($1.70). The assay is economical, simple to perform, and amenable to high-throughput thyroid screening in the routine laboratory.

Autoanalysis↗
PubMed1977

Oxygen consumption during surface-induced deep hypothermia under halothane anesthesia.

The effect of halothane-100% oxygen anesthesia on oxygen consumption was studied in 10 dogs subjected to surface-induced deep hypothermia with 30 minutes of circulatory arrest. The results were compared with previous oxygen consumtion data under ether-100% oxygen anesthesia. Low cardiac output, especially during the rewarming period, low PaO2, and a large arteriovenous oxygen difference during rewarming were significantly different in the halothane group, despite identical oxygen consumption in both groups. These differences could not elucidate the exact cause of postoperative motor disturbances associated with 30 minutes of circulatory arrest in the halothane group. The possibility that there was higher oxygen consumption under halothane anesthesia is discussed.

Anesthesia↗
PubMed1976

Heparinless, oxygenatorless perfusion rewarming following surface-induced deep hypothermia for open-heart surgery.

To facilitate perfusion rewarming without the use of total body heparinization or an oxygenator following open-heart correction with surface hypothermia, we divised a pump circuit. The circuit, totally primed with 100 c.c. of saline, consists of polyurethane-polyvinyl-graphite (PPG) coated Tygon tubes (with one end tapered by heat treatment) and a copper-coil heat exchanger. A roller pump was used to achieve partial bypass from the left atrium to the ascending aorta with flow rates up to 70 c.c. per kilogram per minute. Experiments in dogs resulted in rapid rewarming, immediate return of cardiac function, and hematologic alterations similar to those noted during surface rewarming. The safety of the method was also demonstrated. Prothrombin time, partial thromboplastin time, and platelet values returned to control levels upon rewarming, and no thromboemboli or bleeding problems were noted. Six clinical experiences were accumulated. Details of the method, hematologic and blood chemical analyses in dogs, and the first clinical trial in a 3-month-old infant with transposition of the great vessels are reported.

Animals↗