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Biomedical subjects

G Diaconită

Publications and source records attributed to G Diaconită.

5 recordsLinked to original sources
PubMed1975

Bronchopulmonary carcinosarcoma.

Carcinosarcoma accounted for 0.27% of nearly 3000 lung cancers examined in this department. All the patients were men aged between 44 and 62 years, and a majority of the tumours occurred in the left lung. Three patients died within six months of lung resection and in each case a postmortem examination was performed. In seven the carcinomatous component was a squamous-celled growth, and in one columnar-celled; the histology of the sarcomatous element varied. Carcinosarcomas form a distinct group of malignant lung tumours. In five cases sarcomatous transformation of the stroma had occurred and was considered to be the usual means by which the mixed type of growth arises. The other three were considered to be "collision" tumours. Carcinomatous metastases without sarcomatous change were seen in lymph nodes in three cases, and in three fatal cases sarcomatous tumour had recurred.

Adult↗
PubMedDate not supplied

Morphogenesis and pathogenesis of chronic lung diseases. X. An anatomoclinical and pathogenetic study of 48 pseudotumoral chronic pneumonites.

Forty-eight cases of operated pseudotumoral chronic pneumonites were anatomoclinically and histogenetically studied. Two groups of cases can be established. The first one (21 cases), in which the histogenetic mechanism is related to previous bronchopulmonary infections, suppurations, and immune processes of the immediate type, is characterized by numerous granulocytic foci, granulomatous structure, Arthus type vasculites and fibrous evolution. The unefficient therapy could be one of the determining factors of this evolution, by maintenance of active germs and released antigens. The second group (27 cases) is characterized by hypertrophic bronchites reflecting the prolonged penetration of airborne antigens, by a step by step involvement of peribronchial and parenchymatous structures. A multiphasic development is comparatively demonstrated in the different cases, and dominated by various proportions of plasmocytes and fibroblasts interfering with a restorative granulomatous process involving the intra- and interlobular areas and evolving to a fibrogranulomatous state. Obstructive pneumonitic phenomena and reactive endoalveolitis obliterans interfere, too. Correlations between the dynamics of this picture and the experimental data assert an immune mechanism with repeated immediate and delayed hypersensitivity reactions and auto-aggressive phenomena, determined by released antigens and inductors of cell proliferation and differentiation, as the main processes conducing to the building up of the pseudotumoral chronic pneumonites.

Adolescent↗
PubMedDate not supplied

Experimental aerogenic pulmonary berylliosis in rabbits.

The dynamics of pulmonary changes produced by a prolonged daily administration of 1 g per cent solution of BeSO4 in aerosols was pursued by current histopathological methods in periodically sacrificed rabbits. A progressive constitution of beryliosic granulomas involving intralobular and interlobular areas was observed. The epithelioids and giant cells were present in variable proportions. Concomitantly, a cellular thickening of alveolar walls and perivascular cuffs was noted, as well as an intercellular reticulin fibrillogenesis. The intratracheal three-fold administration of a 0.3 g per cent solution of BeSO4 induced a more rapid formation of berylliosic nodules with the same characters. The relation between the cell accumulation and reticulin fibrillogenesis was morphometrically analysed and statistically verified as pertinent correlated phenomena.

Aerosols↗