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Biomedical subjects

G Dobrescu

Publications and source records attributed to G Dobrescu.

At least 19 recordsLinked to original sources
PubMed1992

Influence of cloprostenol in the experimentally induced ulcer in rats.

We have tested the action of cloprostenol a relatively stable analogue of PGF2 alpha in experimentally induced gastric ulcer in rats by contention stress or indomethacin. Our results show that CIPG, administered at higher doses than those inducing an luteolytic effect, has a gastroprotective effect both in the contention stress-induced ulcer (2.30 + 0.26 in series III as compared to 3.80 +/- 0.73 in series III, p < 0.01) and in indomethacin-induced ulcer (2.69 +/- 0.38 in series V as compared to 3.61 +/- 0.34 in series IV, p < 0.01).

Animals↗
PubMed1979

[34 epibulbar malignant tumours (author's transl)].

Based on a study of 34 cases, the authors make therapeutical and diagnostical references concerning the epibulbar malignant tumours. These were met with a frequency of 10% of the total amount of the malignant tumours of the visual apparatus. The most frequent setting were at the level of the bulbar conjunctiva and of the sclero-corneal limb, especially in front of the opening of the palpebral slit and in the temporal area. The histological examination of the tumours pointed out the following morphological types; epitheliomas (61%), especially spino-cellular, malignant melanomas (32%) and sarcomas (6%). The therapeutical attitude was the surgical one -- the accurate extirpation -- in the limited tumours, followed by radiotherapy when neoplasic lesions were found at the limit of section. In the invaded tumours, the exenteration of the orbit was performed followed by radiotherapy. On the terms of such a therapeutical conduct, the distant prognosis proved to be dependent on two factors: a. The early diagnosis, that is the stage of the therapeutical action. It is insisted upon the importance of the signs of malignization of some benign tumors: papillomas or naevi. b. The nature and origin of the tumour: the secondary tumours are more severe from the beginning.

Adolescent↗
PubMed1977

[Considerations of malignant ocular tumours in children (author's transl)].

The authors undertake a clinico-anatomical study of 27 malignant tumours of the orbit and eye in children seen at the Ophthalmological Clinic in Jassy over the last 12 years. The majority (18 cases) were intra-ocular tumours which were clinically and anatomically retinoblastomas. After presenting the clinical symptoms, drawing attention to the signs of the disease presenting to paediatricians, the treatment is described. This was surgical in all cases followed by radiotherapy according to the case. Analysis of fatal cases and those which survived demonstrate certain degrees of seriousness in clinical, histopathological and therapeutic aspects. It can be appreciated that the long-term prognosis of these cases depends on the early diagnosis and the institution of the correct treatment as well as the anatomopathological form.

Adolescent↗
PubMed1977

A peculiar lymph node anti-carcinoma reaction.

A case of a laryngeal extensive carcinoma determining a severe obstruction is reported, where the development of a monstrous adenopathy is followed by the regression of the initial tumour until complete laryngoscopical disappearance, as well as of obstructive and general symptoms. Cytological and histological examinations of the above-mentioned lymph node demonstrated (besides metastatic cells) a peculiar cellular reaction, similar to rhinoscleroma, which represented an original anti-carcinoma defensive mode. The medical importance of this very rare case is discussed and the probable immune origin of this reactive cellular complex is explained by analogy with "Hodgkinom", where granuloma are the immune response of the body against Sternberg-Reed cell.

Histiocytes↗
PubMed1975

[Myocardial fibroelastosis].

One case of chronic non-obstructive cardiomyopathy diagnosed clinically died suddenly. Post-mortem examination established the diagnosis of endomyocardial fibroelastosis. It was insisted upon the extreme rarity of this form, on the criteria of clinical diagnosis, the diagnosis of cardiomyopathy being one of exclusion, and on the peculiar anatomical characteristics.

Adult↗
PubMed1975

Paget's disease of the breast.

Criteria of the morphological diagnosis as well as the histogenesis of the lesions in Paget's disease are presented; the authors claim that the initial lesion occurs in the lactiferous ducts, the skin being secondarily involved. Likewise, the dyskeratotic lesions are considered as secondary to the neoplastic process, either by neoplastic induction or by mobilization and proliferation of cancerous cells from lactiferous ducts. The utility of biopsies in all cases of nipple eczema, and of the histologic investigation of the profound tissues is pointed out. In this way the canalicular starting point in the vicinity of the nipple can be noticed.

Breast↗
PubMedDate not supplied

Histochemical and histoenzymic researches in coronary sudden death.

Using Lie's technique in order to evidence the fuchsinophilia of the early ischaemic zones and Falck-Hillarp's technique to appreciate the disappearance of the myocardial adrenergic network, the authors followed up the concordance between the precocity of the ischaemia and the frequency of the acidophilia. Studying 54 cases of coronary sudden death by using 100-300 slides in each case, the fuchsinophilic zones were evidenced in 46 per cent of the cases, aspects indicating the morphologic substrate of the sudden death with ectopic ventricular electrical activity centres. The results of fluorescence Falck-Hillarps's technique are the same as those obtained by light microscopy, which is to be preferred in routine practice. Farber-Louvière's microscopic histoenzymic method for succinate-dehydrogenase presents multiple advantages, so that it is preferable to Kollin-Neoral's macroscopic reaction.

Catecholamines↗
PubMedDate not supplied

[Metabolic and cardiovascular changes in experimental diabetes, stress and orchiectomy].

When Aloran (Al) was administered to normal or orchiectomized animals, the adult ones proved to be more sensitive, most normal animals (77.7%) developing a DAla and the remainder (22.3%) a DAlc, while of the orchiectomized animals 66.6 developed a DAlc and 33.4% presented a decreased glucose tolerance. 33.4% of the young normal developed a DAla and 66.7% a DAlc, while of the young orchiectomized ones 33.4% presented a DAlc and 66.7% a STG. No matter of age, orchiectomy induced an increased resistance to the various action of Al. Glycemia and lipid fractions, especially LT and TG were significantly elevated in the normal animals with DAla and in the young orchiectomized animals with DAlc. Insulinemia was elevated in most young animals, except for the orchiectomized ones with DAlc, in which it decreased. Serum cholesterol was the most markedly elevated in the adult animals belonging to the group ACTH + D2 + Al, form DAlc. Histopathologically, in this last group degenerative lesions and microcalcifications in aorta and interstitial infiltrate and homogenization of myocardial fibres in the myocardium were found.

Adrenocorticotropic Hormone↗