Biomedical subjects

G Dokianakis

Publications and source records attributed to G Dokianakis.

At least 19 recordsLinked to original sources

PubMed2001

Smoking and alcohol in the etiology of oral cancer: gender-specific risk profiles in the south of Greece.

Oral and pharyngeal cancer (OC) mortality is very low in Greece, especially among men, compared to other European countries. We conducted a case-control study of OC in Athens, and obtained information on tobacco, alcohol use and other potential risk factors and confounding variables for 110 incident cases and 115 hospital-based controls. We used multivariate logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Tobacco smoking (pack years, P(trend)=0.01) and alcohol use (drinks/week, P(trend)=0.07) were independent risk factors, with a multiplicative effect for combined exposures (OR, 8.3; 95% CI, 2.4-29.1, for >28 alcohol drinks/week and >50 pack years of cigarette smoking). The type of alcoholic beverage also seemed important: drinking ouzo and tsipouro (liquors of high ethanol concentration) was associated with greater increased OC risk than drinking comparable amounts of wine, beer or dark spirits. While alcohol drinking is more common for male cases versus controls, few men reported regularly consuming large quantities of ethanol associated with highest risk of OC in other studies. This may partially explain the low rates of male OC mortality in Greece. Among the 38% of our cases who were women, however, neither smoking nor alcohol drinking frequencies were significantly elevated compared to controls, and so the etiology of OC risk in females requires further investigation.

Adult↗

PubMed2001

Sequential chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil in patients with locally advanced head and neck cancer.

The purpose of this phase II trial was to evaluate the toxicity of a sequential chemoradiotherapy approach using docetaxel, cisplatin, and 5-fluorouracil (5-FU) (DCF) with granulocyte colony-stimulating factor support in previously untreated patients with locally advanced head and neck cancer (HNC). Secondary endpoints included preliminary assessment of response. Patients with locally advanced HNC, a World Health Organization performance status 0 to 2, and no prior history of chemotherapy or radiotherapy were included. Treatment consisted of docetaxel 80 mg/m2 (1-hour infusion) on day 1, cisplatin 40 mg/m2 (1-hour infusion) on days 2 and 3, and 5-fluorouracil 1,000 mg/m2 (24-hour continuous infusion), on days 1 to 3, repeated every 28 days for a maximum of 4 cycles per patient. All patients received granulocyte colony stimulating factors subcutaneously between days 4 and 9. Radiation therapy (RT) to the primary tumor site and neck lymph nodes was planned within 5 weeks of the last cycle of chemotherapy. The primary tumor site received 60 to 70 Gy. Twenty patients (median age 56 years, range: 40-72 years) received a total of 60 cycles of DCF. The median number of cycles was 3 (range: 1-4 cycles). All patients were evaluable for toxicity and response. The most common acute nonhematologic toxicities from DCF induction chemotherapy included alopecia, mucositis, peripheral sensory neuropathy, onycholysis, and asthenia. Febrile neutropenia developed in two patients and grade IV diarrhea in one patient. There were no treatment-related deaths. The overall response rate (RR) after DCF induction chemotherapy was 90% (95% confidence interval [CI]: 76.8-103.1%). After the completion of RT, the overall RR was 95% with a complete response rate of 73% (95% CI: 49.9-90.1%). Organ preservation was achieved in eight patients with laryngeal cancer and one patient with base of tongue involvement. After a median follow-up of 36 months (range: 5-43 months) the median disease-free and overall survival have not been reached yet. The 1- and 2-year survival rates were 85% and 60%, respectively. Sequential chemoradiotherapy with DCF and growth factor support is feasible and very active, with durable responses in patients with locally advanced head and neck cancer. Further evaluation of this modality is justified in the context of a clinical trial.

Adult↗

PubMed2000

Ectopic thymic cyst in the neck.

Ectopic thymic tissue in the neck is rarely reported in medical literature. This paper presents the case of a young female, who presented with a soft, fluctuating mass in the left side of her neck. Surgical excision revealed an ectopic thymic cyst. Ectopic thymic tissue may be an infrequent finding, but it should be included in the differential diagnosis of neck masses, especially in children. This case report is accompanied by a short review of the relative literature.

Adult↗

PubMed1998

An unusual case of otogenic pneumocephalus.

Otogenic pneumocephalus is a rare entity usually caused by temporal bone trauma. This paper describes a case of otogenic pneumocephalus of traumatic origin, in which the type of the fracture (a bony spicula was detached from the mastoid) and the location (Trautmann's triangle) were uncommon.

Accidental Falls↗

PubMed1994

Pharyngocutaneous fistula after total laryngectomy: incidence, cause, and treatment.

Postoperative pharyngocutaneous fistula is a major complication of total laryngectomy that prolongs the short hospitalization of 2 to 3 weeks to many weeks or even months. It is a common complication that increases the morbidity and mortality of the procedure. In the Department of Otolaryngology of the Red Cross Hospital of Athens, 310 patients underwent total laryngectomy from January 1980 through December 1989. Twenty-eight patients developed a fistula (incidence 9%). The incidence, predisposing factors, and methods of treatment of this complication are analyzed and discussed.

Carcinoma, Squamous Cell↗

PubMed1992

[Is there a time limit for the treatment of sudden hearing loss?].

Improvement of hearing after-acute hearing loss, is more possible during the first days after its onset and the explanation remains unclear. When recovery of hearing happens many weeks later, this could be considered as a rare situation. During the last 8 years, we had 11 cases in which there was recovery of hearing within 4-26 weeks. In one case hearing recovery happened spontaneously and in the other cases after the application of a therapy schedule. In this paper, we present the audiological findings and we discuss the possible pathogenetic mechanism of this entity. Additionally, we stress the significance of that knowledge, in cases of medicolegal problems.

Adult↗

PubMed1990

[Congenital fistula of the 4th pharyngeal pouch and cleft].

This is the first description of a fistula arising from both the fourth branchial cleft and the fourth pharyngeal pouch in a 62-year-old woman. This developmental anomaly ran from the piriform sinus to the skin of the left side of the neck. A small quantity of liquid was seen to flow from the external opening of the fistula during drinking or swallowing. Surgery revealed a tract inferior to the superior laryngeal nerve and lateral to the recurrent laryngeal nerve. This fistula penetrated the larynx in the region of the cricothyroid joint and ended in the piriform sinus. This patient had neither suffered infection of the fistula, nor had undergone a prior surgical procedure.

Branchioma↗

PubMed1988

[Malformations of the first branchial cleft and facial nerve].

First branchial cleft anomalies are a rare but interesting group of congenital anomalies of the neck. They produce a great variety of clinical manifestations and have a close relationship with the facial nerve and the auditory canal. Surgery is the only effective treatment of these anomalies and complete surgical removal must be achieved to avoid recurrence. Our experience with 1 11 cases operated on in the last 9 years in our clinic is presented in this paper. The relationship of the facial nerve with the congenital anomaly is emphasized.

Adolescent↗

PubMed1980

Ectopic thyroid gland in the submandibular region.

A rare case of an ectopic thyroid gland appearing as a submandibular mass in a 30-year-old female patient is presented. Special emphasis is placed on the origin, unusual location, functioning status, pathology and diagnostic problems created by this interesting case.

Adult↗

PubMed1979

[Paraganglioma of the nodose ganglion of the n. vagus].

A case of a 47-years-old female patient treated for a vagal body tumor is presented. The origin, clinical appearance and special diagnostic and therapeutic problems created by this rare tumor are discussed.

Cranial Nerve Neoplasms↗

PubMed1978

[Hearing loss and hyperthyroidism (author's transl)].

The audiometric findings on 23 patients with diquited hypothyroidism for a minimum of 4 months to a maximum of 20 years are presented. Audiometric tests, including acustic impedance measurements (tympanometry, stapedius reflex) were performed on all patients before and after an adequate substitution therapy. In 12 patients there was a definite impairment of hearing before the substitution therapy. Eight of them have shown a mild to moderate sensory-neural deafness. Four showed a mixed deafness, in three of which a negative pressure of 300 mm H2O was measured in the middle ear, the fourth one had a seromucotympanon. In three patients with pure sensory-neural deafness the stapedius reflex was elicitated only 30 dB over the pure tone threshold in speech frequencies. The audiometric measurements after an adequate substitution therapy of minimum 4 months has shown a definite improvement of hearing loss.

Acoustic Impedance Tests↗

PubMed1978

Granular cell myoblastoma of the larynx.

Two cases of granular cell myoblastoma of the larynx are presented. In the first case the tumour was excised by laryngofissure, and in the second case by microlaryngoscopy. Based on this experience a review of this interesting tumour is made, and emphasis is given to the fact that this neoplasm may be mistaken for squamous cell carcinoma.

Adult↗

PubMed1978

A schwannoma of the parotid gland. Report of a case.

An unusual case of multiple schwannomas of the parotid gland in a 44-year-old male is presented, and the natural history of the disease is discussed. Neural tumours of the salivary glands are rare, and the treatment of choice is surgery. Recurrence seems to be unusual unless the excision is incomplete.

Adult↗

PubMed1978

57Co-bleomycin imaging study of tumors of the head and neck.

57Co-Bleomycin (57Co-BLM) was used to visualize malignancies of the head and neck because it does not present the disadvantages of many other radiopharmaceuticals. In a series of 21 patients with 9 control subjects and 12 cases of tumors. 57Co-BLM showed a high and rapid uptake in primary site and metastases of malignant tumors of various histologic types, but not in benign tumors such as angiofibromas. Compared to 67Ga-citrate. 57Co-BLM has many advantages for tumor imaging in the areas of nose, pharynx and larynx: No background activity due to the concentration of 57Co-BLM in normal structures of the head and neck has ever been observed, as opposed to what happens with 67Ga-citrate. Furthermore, the blood clearance of 57Co-BLM is much more rapid than that of 67Ga-citrate, so that an early study may be performed in a 6-24 hr. interval instead of 48-72 hr. with 67Ga-citrate. 57Co-BLM scintigraphy is an easy, non-invasive and sensible diagnostic technique in determining the extent of malignant tumors in ORL patients.

Bleomycin↗

PubMed1978