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Biomedical subjects

G Drobinski

Publications and source records attributed to G Drobinski.

At least 145 records · Page 8Linked to original sources
PubMed1979

[Echocardiographic diagnosis of obstructive myocardiopathies: study of the systolic anterior motion of the mitral valve and septal hypertrophy as compared with the hemodynamic and mechanographic findings. Evolution under medical treatment].

Characteristic echocardiographic features of hypertrophic obstructive cardiomyopathy were recorded in 24 patients, all of whom had asymmetric septal hypertrophy and systolic anterior motion of the mitral valve (SAM) at rest or after pharmacodynamic stimulation. The relationship between outflow tract obstruction and SAM was assessed by comparison with data obtained at cardiac catheterisation and external mechanography: SAM seems to be a non-specific phenomenon and may be recorded in cases of hypertrophic cardiomyopathy without obstruction during pharmacodynamic stimulation. In forms with obstruction, SAM and the severity of obstruction increase with the degree of spetal hypertrophy. The increased contractility of the left ventricular posterior wall appears to be an important factor in the mechanism of SAM which can be prevented by betablockade in moderate or labile forms. When SAM is permanent, whatever the gradient recorded, it is a sign of anatomical deformation of the left ventricle and may be an additional indication for cardiac surgery.

Adrenergic beta-Antagonists↗
PubMed1979

[Diagnostic value of hemodynamic and angiographic studies in right medioventricular subinfundibulaire stenosis (author's transl)].

Two cases are reported of right medioventricular subinfundibular stenosis with intact intraventricular septum. This rare congenital malformation, also known as "double chambered right ventricle", and usually associated with an intraventricular communication, can only be diagnosed with certainly on the results of hemodynamic and angiographic studies which demonstrate the abnormal medioventricular muscle bands. A steep intraventricular pressure gradient was noted in the first patient who was operated upon successfully. The second patient developed progressively increasing stenosis which underlines the need for long-term observation of cases in which there is little initial obstruction. Particular types of electrocardiographic recordings, not previously reported, were present in both cases; in one there was an unexplained long QT interval; in the other a first degree nodal atrioventricular block with atrial arrhythmia, requiring the implantation of a cardiac stimulator.

Adult↗
PubMed1979

[Atypical forms of Ebstein's disease: value and limitations of ultrasonography and cardiac catheterization (author's transl)].

Diagnostic ultrasonography signs of Ebstein's disease are delayed closing of the tricuspid valve in relation to the mitral valve, and the possibility of recording from the tricuspid valve when the transducer is outside of the left median clavicular line. These criteria were present in 8 out of a series of 10 cases and 6 of these patients had also had haemodynamic tests which showed auricularization of a portion of the right ventricle in all of them. Details are described for 3 of these patients to illustrate the different atypical clinical forms of Ebstein's disease, and the value and limitations of complementary investigations for establishing the diagnosis of this affection.

Adolescent↗
PubMed1979

[Immunological study of primary non-obstructive myocardiopathies. A report on 37 cases (author's transl)].

The pathogenicity of primary non-obstructive myocardiopathies remains unknown at the present time. Immunological disturbances have been demonstrated but their role is open to discussion. A comparison between 37 such patients and 37 control subjects with cardiac insufficiency, similar according to age and sex, gave the following results: circulating immune complexes levels, anti-organ or anti-tissue antibody levels, and the levels of serum complement and its fractions were the same in both groups. Serum IgA levels were significantly higher in the "patient" group, and this appears to be partly related to alcoholism. Finally, an antimyocardial cellular immunity exists. These results would appear to demonstrate that conventional immunological techniques are of limited value in primary cardiac insufficiency.

Adult↗
PubMed1978

[Recurrent ventricular tachycardia and parchment right ventricle in the adult. Anatomical and clinical report of 2 cases].

Two patients, aged 52 and 55 years, were admitted to hospital for attacks of recurrent ventricular tachycardia for which preventive treatment was difficult. The crises were of one type, with left-sided delay. The findings on clinical examination, electrocardiography, haemodynamic and arteriographic investigation and at post-mortem were those of the parchment right ventricle syndrome of the adult. Electrophysiological investigation in the 2 cases indicated that a re-entry mechanism underlay the attacks of tachycardia. Late activation of the pulmonary infundibulum was responsible for a post-excitation potential on the surface and intra-cavitary leads. Mapping carried out during ventricular tachycardia in one case demonstrated the pathway for re-entry at the level of the pulmonary infundibulum.

Electrophysiology↗
PubMed1978

[Paradoxical displacement of the interventricular septum with impairment of filling of the left ventricle. Echocardiographic and hemodynamic diagnosis. Apropos of 3 cases].

An unusual type of displacement of interventricular septum, the inverse of that found normally, was found by echocardiography in 3 cases: 2 with pulmonary arterial hypertension and 1 with constrictive pericarditis. In two cases catheterisation showed the haemodynamic picture of mitral obstruction, and in 1 case the typical findings on auscultation of mitral stenosis were present. The echocardiogram and anatomical studies showed that the mitral valve was normal. The obstruction was due to displacement of the septum towards the left ventricle during diastole. Because of this displacement, the septum came into contact with the mitral valve, and caused impairment of the filling of the left ventricle.

Adult↗
PubMed1977

[Myocardial infarction and heterozygous sickle cell anemia. Apropos of 2 cases].

Thromboses are a classical complication of sickle cell disease in the severe homozygous form. In the heterozygous individual, although the risk of severe thromobotic episodes is small, it must nevertheless be recognised. The authors report two cases of myocardial infarction in patients whose coronary arteries were relatively free from atherosclerosis; they were young men, with the heterozygous form of sickle cell disease AS. The part played by inheritance, the factors favouring vascular occlusion, and the possibility of preventing such episodes are all discussed.

Adult↗
PubMed1977

[Echocardiographic study of the left ventricle in aortic insufficiency. Comparison with the data of clinical development and hemodynamic results].

A series of 20 patients with pure and severe major aortic incompetence was studied, and three different groups were distinguished: group I, with no previous defect in function; group II, with cardiac failure as a result of aortic incompetence of more than 5 years' standing; group III, with cardiac failure secondary to acute aortic incompetence. The internal diameter of the left ventricle and the mode of closure of the mitral valve were studied by echocardiography, and compared with the clinical and haemodynamic findings. Left ventricular dilatation appeared early, and occurred to the same degree in the three groups. The diastolic diameter of the left ventricle showed a fairly close correlation (r equals 0.61) with the degree of regurgitation as measured from clour dilution curves; by contrast, the length of time the aortic incompetence had been present had little influence on the degree of dilatation of the left ventricle. Premature closure of the mitral valve was significantly associated with a raised LVEDP and a low systolic index; it represents a defect in the compliance of the left ventricle, and is a poor prognostic factor because of the clinical progression into very rapid and severe heart failure. Moreover, there is a distinct aetiological factor (Infective endocaditis) in the most marked forms of premature closure. The other ecocardiographic findings (appearances of the aorta, mitral echo, slope EF of the mitral valve) give no information on the degree of tolerance to the cardiac defect.

Adult↗