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Biomedical subjects

G Dumas

Publications and source records attributed to G Dumas.

14 recordsLinked to original sources
PubMed1992

Sex does not influence serum osteocalcin levels in standardbred horses of different ages.

The influence of sex on serum osteocalcin levels was studied in 99 Standardbred horses, 52 males and 47 females. The age varied between the day of birth and five years old. A significant inverse correlation (r = -0.87, p < 0.01) was observed between serum osteocalcin level and the age of the animal. Sex did not influence serum osteocalcin level (p > 0.05). When the subjects were divided into five age groups of six months or less, 6 to 18, 18 to 24, 24 to 36 and between 36 and 60 months, no significant influence of sex was noted. A predictive model for serum osteocalcin levels (y = 52.19 - 0.026 age in days, r2 = 0.76) for Standardbred horses aged between the day of birth and five years is described.

Aging↗
PubMed1991

T cell response to myelin basic protein epitopes in multiple sclerosis patients and healthy subjects.

T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence of the peptides spanned the complete sequence of the human BP. The results suggest the development of T cells sensitized to at least four independent regions of the human BP, indicating some diversity of the human T cell repertoire to BP. However, an immunodominant T cell epitope was located in the C-terminal region, defined by residues 149-162. This epitope was recognized by T cells from three subjects out of five (one MS patient and both healthy controls) in the context of different DR specificities. Another epitope (located in the 57-75 region) which triggered one MS patient's T cell response was also recognized by a mycobacteria-specific T cell clone cross-reacting with BP.

Epitopes↗
PubMed1991

Atrophic rhinitis caused by Pasteurella multocida type D: morphometric analysis.

In order to study the distribution and the extent of atrophy caused by Pasteurella multocida in the nasal conchae, experimental piglets were injected intramuscularly at seven days of age with either two or four 50% mouse lethal doses per kg body weight of P. multocida type D dermonecrotoxin. Experimental and control piglets were killed four, six and ten days postinjection. Serial transverse paraffin embedded sections of the noses were cut throughout the entire length of the nasal conchae. The area of the nasal ventral conchae was measured and the morphometric index of the nasal cavity was calculated. It was observed that P. multocida type D dermonecrotoxin induced severe atrophy of the nasal ventral conchae. This atrophy was present along the entire conchae. However, it was most severe at the level of the first and second premolar teeth.

Animals↗
PubMed1991

[Malformations of the bony labyrinth and deafness].

17 new cases of malformation of the bony labyrinth detected radiologically (tomography, CT) and associated with perceptive or composite deafness are reported. 2 cases discovered in spontaneous or traumatic recurrent meningitis are described, as well as 1 case discovered after the occurrence of total deafness following stapedial surgery. The malformations were unilateral in 7 cases, bilateral in 10. Deafness was of the composite type in 6 cases. An associated malformation of the middle or external ear was noted in 4 cases. 5 cases were included in a context of multiple malformations, including 1 case of otobranchiorenal syndrome, 1 case of Apert's syndrome and 3 cases of craniostenosis. Referring to the classification given by Mrs Vignaud and Jardin, we have encountered 1 case of stage I malformation, 9 cases of stage II, pseudo-Mondini malformation, 1 case of stage III or true Mondini malformation, 1 case of stage IV malformation, 3 cases of malformation of the aqueduct of the vestibule, ie. stage V. We have also encountered 2 isolate cases of stenosis of the internal auditory canal. On the basis of these cases, we report a few physiopathogenetic hypotheses and various classifications currently described in the literature. We also list the various associated external and middle ear malformations and the multiple-malformation syndromes that are commonly described. Stress is laid on the fact that these malformations often go undetected in congenital deafness, as well as on the usual course of these types of deafness for which there is no medical or surgical treatment.

Abnormalities, Multiple↗
PubMed1988

[Contribution of oculography and magnetic resonance imaging to the clinico-topographic correlates in ischemic vascular disorders of the brainstem].

6 patients with brainstem infarction and oculomotor signs were studied. One case was consistent with a mesencephalic infarct (internuclear ophthalmoplegia); 4 cases were consistent with a protuberantial infarct (3 cases of "one and a half" syndrome and one case of pontine reticular syndrome associated with a palsy of the root of the VIth nerve. One case was a laterobulbar syndrome. These 6 patients were studied with CT scan and magnetic resonance imaging (MRI CGR Magniscan 5000 with supraconductor magnet of 0.5 Tesla) with T2 weighted images (TR = 2000 ms, TE = 60; 120 ms) in joined section of 9 or 6 mm thickness. The MRI findings were in each case consistent with an infarction. The clinico-topographic correlations are compared with the oculographic findings.

Brain Ischemia↗
PubMed1978

[Facial nerve tumors: three cases (author's transl)].

The first one is a neurofibroma associated with a Charcot-Marie Tooth's disease involving all the tympanic segment of the facial nerve: extirpation and graft. Improvement of facial motricity to 42%. The second one is a small Schwannoma lateral to tympanic segment: extirpation without paralysis. The third is a large Schawannoma of the tympanic mastoïd segments involving the facial nerve to its division in the parotid gland, and with a limited extension in the cerebello-pontine angle. Extirpation and graft. Discussion and recent bibliography.

Adult↗