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G Dumont

Publications and source records attributed to G Dumont.

At least 37 records · Page 2Linked to original sources
PubMed1981

Suitability of control materials. General principles and methods of investigation.

We propose methods for characterizing the behavior of quality-control specimens. Candidate quality-control specimens and authentic patients' specimens were analyzed by various methods. Patients' specimens were chosen to be fully representative of those encountered, including subsets from persons who were healthy, had defined disease states, were in therapy, or whose specimens were lipemic, icteric, etc. The analytical methods chosen include those most commonly used as well as reference analytical methods. Procedures for characterizing the behavior of patients' specimens and candidate quality-control specimens are proposed and their applicability is demonstrated. The linear ratio method is a univariate graphical approach in which differences in accuracy among methods for any specimen or group of specimens are each displayed on a linear scale. Correspondence analysis is a descriptive multivariate statistical technique that allows both the specimens and the analytical methods to be characterized. The statistical techniques, in our application, allow the behavior of quality-control specimens to be assessed with respect to authentic patients' specimens without influencing the assessment process. Correspondence analysis provides a graphic representation by projecting both the specimens and the analytical methods on factorial planes. The appropriateness of te behavior of a quality-control specimen may be inferred from its position relative to those of authentic patients' specimens. These statistical techniques also provide some information regarding the specificity of analytical methods.

Blood Chemical Analysis↗
PubMed1977

Pharmacokinetics of lidocaine after prolonged intravenous infusions in uncomplicated myocardial infarction.

The kinetics of the elimination of lidocaine upon discontinuation of lidocaine infusions lasting more than 24 h were studied in 12 patients with uncomplicated myocardial infarctions. In this group of patients the mean half-life of the elimination phase was found to be 3.22 h. This is significantly different from the half-life of 100 min that has been reported after bolus injections or infusions lasting less than 12 h. This longer half-life should be taken into consideration in estimating the duration of toxicity and the rate of administration of the drug during and after intravenous infusions lasting 24 h or more.

Female↗
PubMed1977

Effects of sotalol in twenty patients with cardiac arrhythmias.

Sotalol was given intravenously at doses of 20 to 60 mg to 20 selected patients with various cardiac arrhythmias. Ten of these patients subsequently received oral sotalol at doses of 80 to 160 mg twice a day. The drug was beneficial in 2 out of 2 patients with sinus tachycardia and in 4 out of 7 patients with other supraventricular tachycardias. The drug was particularly effective in lidocaineresistant ventricular arrhythmias since it was effective in 9 out of 11 patients. The blood pressure of the 4 patients who were hypertensive was significantly lowered while that of the normotensive patients was not affected. Three patients who suffered from severe myocardial disease developed sinus bradycardia, which was life-threatening in 2 of them.

Administration, Oral↗
PubMed1975

Splanchnic blood flow in essential hypertension and in hypertensive patients with renal artery stenosis.

Splanchnic blood flow (SBF) was measured simultaneously with cardiac output (dye dilution) and intrarterial blood pressure by constant infusion of indocyanine green in 11 control subjects, 13 patients with essential hypertension (EH) and seven hypertensive patients with renal artery stenosis (RAS). The cardiac index (CI) was lower (P less than 0.05) in patients with EH (3.17 plus or minus 0.07 L/min/m-2) (mean plus or minus SEM) than in control subjects (3.43 plus or minus 0.09). Associated with the lower CI was a significantly (P less than 0.01) lower SBF (0.797 plus or minus 0.02 L/min/m-2 vs 0.889 plus or minus 0.04). Patients with RAS presented with higher (P less than 0.01 vs EH, nonsignificant vs control subjects) cardiac index (3.66 plus or minus 0.17) and even lower SBF (0.749 PLUS OR MINUS 0.02). Furthermore, there was a negative correlation (r = - 0.652) between the mean arterial pressure and the SBF when results for all patients were considered. The correlation remained (r = - 0.568) in the EH group and the slope of regression line was not different from that for all subjects. The CI and SBF were weakly correlated (r = 0.423) in control subjects and patients with EH, whereas in patients with RAS, a negative correlation was found (r = - 0.778). This study indicates that the SBF, although significantly decreased in patients with EH, remains proportional to the CI in control subjects and in essential hypertensive patients. No redistribution of CI in regard to the splanchnic circulation occurs in EH. In contrast, in patients with RAS a dissociation of CI and SBF occurs and the fraction of the CI which passes through the splanchnic vascular bed is markedly reduced. The close correlation between mean arterial pressure and SBF suggests that both parameters are influenced by a common pathophysiological factor.

Abdomen↗
PubMedDate not supplied

[Intestinal obstruction in pregnancy].

Intestinal obstruction is a rare but dreadful complication of pregnancy. Both the mother and the foetus may be severely affected and even die. The authors here report their recent experience and review the literature. They emphasize that diagnostic pitfalls are common during pregnancy and there appropriate management most often delayed. A multidisciplinary approach is advocated and the specific aspects of this high-risk situation are discussed.

Adult↗