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Biomedical subjects

G Dutau

Publications and source records attributed to G Dutau.

At least 19 recordsLinked to original sources
PubMed1992

Continuous subcutaneous infusion of beta 2-agonists in infantile asthma.

Eleven infants presenting with an asthmatic syndrome were treated with subcutaneous infusions of a beta 2-agonist (beta 2A) during an acute episode. This treatment was used after difficulties with or failure of beta 2A infusions and IV nebulizations. No local or general adverse reactions were observed. The serum concentrations of salbutamol obtained at a dose of 0.1 micrograms/kg/min were measured in six infants and found to be within the generally accepted therapeutic range. This mode of administration proved extremely useful, both by itself and as part of a therapeutic protocol, combined with an antibiotic, a corticosteroid, and theophylline. It avoids the difficulties of administering beta 2A intravenously or by nebulization, while preserving some degree of freedom and better general care for the child. The preferred indication is in treatment of severe acute asthmatic episodes after failure of nebulizations. The exact place in the therapeutic arsenal of infantile asthma remains to be defined.

Adrenergic beta-Agonists↗
PubMed1992

Immunostimulant effects on granulocyte functions during an acute respiratory infection.

Treatment of healthy volunteers by Ribomunyl, whether or not in association with in vitro antibiotics (amoxicillin or josamycin), has been earlier demonstrated to be an efficient stimulant of PMN functions (adhesion and migration). This second double-blind study versus placebo was performed on 17 patients with acute respiratory infections (placebo group: eight subjects; Ribomunyl group: nine subjects). Ribomunyl treatment (four days) associated with antibiotherapy (amoxicillin) induced a significant increase of PMN adhesion (p = 0.014) with no significant effect of the placebo (p = 0.30) and no significant difference between the initial level of PMN adhesion of the two groups (placebo-Ribomunyl).

Adolescent↗
PubMed1992

[A unilateral hyperlucent lung...].

The occurrence in a young patient of a chronic cough with dyspnoea and restrictive ventilatory failure as shown by respiratory function tests suggested the possibility of a Mac Leod syndrome. However, other aetiologies could be considered such as vascular malformations, bronchial malformations and also tumours. If the chest X-ray sometimes enables an aetiological slant, bronchoscopy remains a first line investigation.

Adolescent↗
PubMed1990

[Continuous subcutaneous infusion of beta 2-agonists in infantile asthma].

Five infants aged 7 to 17 months were treated for asthma with a continuous subcutaneous infusion of a beta 2-agonist for 6 to 11 days in a dosage of 0.1 microgram/kg/mn. The patients had a severe attack of asthma with problems with infusions and/or problems with nebulizations of beta 2-agonists and/or bronchial stasis. No local or systemic adverse effects were recorded. This mode of administration of beta 2-agonists proved extremely useful, either as single therapy or as part of a therapeutic protocol including antibiotics, steroids and theophylline. It avoids the problems met with administration of beta 2-agonists by the other routes and allows the child freedom of movement. The main indication is the severe attack of asthma that fails to respond to nebulizations. We suggest this new therapeutic method should be included in the therapeutic armamentarium for infantile asthma, although its exact place and indications need to be further defined by studies in a larger number of patients.

Administration, Inhalation↗
PubMed1990

[Detection of respiratory allergies using the Phadiatop test in children 1 to 6 years of age].

Phadiatop, a new test for detecting hypersensitivity to airborne allergens, was used in 83 children aged 9 months to 6 years with recurrent respiratory manifestations, i.e. recurrent expiratory obstruction and/or recurrent respiratory infections. A good correlation was found between this test and both the prick tests (95%) and the specific IgE assays (91% for RASTS of classes greater than or equal to 1, and 95% for RASTS of classes greater than or equal to 2). However, the correlation was less strong with the total IgE level (68%). The overall correlation with the specialist's prediction based on history and physical evaluation was excellent (94%). In this study, Phadiatop was found to have a 90% sensitivity and a 98% specificity. Furthermore, this test costs 40% less than the often used strategy combining skin tests and determinations of total and specific IgE levels. In the age group studied, Phadiatop is most useful above the age of two, since in younger patients true respiratory allergies are fairly infrequent in recurrent ENT and lower respiratory tract infections, whereas infections are far more common.

Child↗
PubMed1990

[Is there a consensus among specialists concerning asthma?].

A list of 30 questions--of which 25 were literal translations of the questions asked by R.L. Henry and A.D. Milner (British Medical Journal 1983, 287, 260-261) and 5 were new questions--was presented to 118 specialists of asthma selected among the members of the European Academy of Allergology. A consensus (more than 75% identical answers) was observed for 17 questions. Surprisingly, only 50% of French specialists perform lung function testing on one occasion, since concomitantly the importance of periodic evaluation of "breathing" was underscored. Comparison with answers given by British practitioners raises the question of why a chronic disease such as asthma is managed differently despite comparable severity. The urgent need for a definition of "good diagnostic and therapeutic practices in asthma" is pointed out.

Adolescent↗
PubMed1990

[Pneumopleurocutaneous fistula after inhalation of an ear of barley (Hordeum murinum)].

A 16-month-old boy developed a cutaneous swelling at the base of the right hemithorax with fever. The chest film showed evidence of a very slight pleural effusion and the xerography disclosed subcutaneous emphysema opposite the swelling. Three weeks earlier, the child had been found in a field with an ear of grain in his hand and apparently exhibited a transient episode of choking. An article published several years ago by an anglo saxon author, T.R. Cavens, on pneumocutaneous fistulas secondary to the inhalation of grasses suggested that our patient had a similar condition. The abscess was opened and an ear of barley (Hordeum murinum) was found. Less than ten comparable observations have been published in the literature. We recall a number of botanical facts explaining why an ear of Hordeum murinum can migrate only in the forward direction.

Edible Grain↗
PubMed1988

[In vitro diagnosis of food allergy. Correlations among different diagnostic methods].

Diagnosis of immediate-type food allergy (AA) needs several kinds of investigation. To make their respective values clearer, we have studied the correlations that may exist between clinical scores, prick-tests (PT), oral provocation tests (TPO), measurement of fixed IgE on the polynuclear basophils (TDBH) free, serum IgE (RAST) and lymphoblast transformation (TTB) in 105 patients aged from 5 months to 17 years 3 months, who were suspected of AA. The weakest tests were PT and TPO of which the use (or not) at first were the two possible diagnostic approaches for AA. The study of the linear correlations between the different diagnostic tests taken two by two showed that there was a statistically significant correlation - the only one that we found - between PT and RAST (p2 less than 0.001). Finally, the level of agreement between PT and TPO was 86%.

Adolescent↗
PubMed1987

[Various methods for the diagnosis of allergy in pediatrics. Some correlations between different tests].

We studied the correlations between the different methods of diagnosis of the immediate allergy, IgE-dependent, in two current cases of pediatric allergology. In the mites allergy, the best correlation is observed between the skin tests (IDR) and the Rast. During the food allergy, first we found the best correlations between the prick-tests (PT) and the oral challenge (TPO), then between the prick-tests and the Rast. In these two studies, we got no further element to the diagnosis from the direct test of human basophil degranulation (TDBH).

Adolescent↗