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Biomedical subjects

G E Anderson

Publications and source records attributed to G E Anderson.

11 recordsLinked to original sources
PubMed1990

Clinical accuracy of continuous hemoglobin oxygen saturation monitoring devices.

Three devices used to measure hemoglobin oxygen saturation in the extracorporeal circuit were studied and compared to a control. The Baxter Bentley OxySat, Oximetrix Accusat, and Radiometer ABL4 blood gas monitor were compared to a control, the IL 282 Co-Oximeter. Fifty-one sample points were obtained during all phases of cardiopulmonary bypass with results as follows: table: see text. The Accusat was found to be a statistically more accurate means of monitoring hemoglobin oxygen saturations during cardiopulmonary bypass than the ABL4 and the OxySat. All devices had significant correlation with the control and with each other.

Adult↗
PubMed1981

Hormonal and metabolic effects of a pancreatic endocrine graft. Vascularized segmental transplantation in insulin-dependent diabetic patients.

A new modification of pancreas transplant technique, the vascularized segmental intraperitoneal graft without duct ligation, has provided reversal of insulin-dependent (type I) diabetes mellitus for as long as 2 years of comfortable life. Although the risks associated with immunosuppression remain high (two of the 12 patients have died of early postoperative infection), selected data are presented from six cases to show the following striking hormonal and metabolic results after transplantation and withdrawal of insulin: restoration of normal beta cell function as shown by 24-hour urine C-peptide excretion and acutely responsive serum insulin, restoration of normal suppressibility of plasma glucagon, elimination of ketosis and negative nitrogen balance, normal fasting plasma glucose and glycosylated hemoglobin, and normal or near-normal glucose tolerance. These results provide a standard for current explorations of new ways of treating insulin-dependent diabetes.

3-Hydroxybutyric Acid↗
PubMed1975

Developmental and behavioral changes in the rat during chronic exposure to lead.

Young male and female Sprague-Dawley rats were given drinking water containing 5 or 50 ppm Pb for 40 days prior to mating. Pregnant females were continued on these regimens throughout gestation and lactation. After weaning the offspring were similarly exposed through adulthood. Reflex development, body weights, and locomotor activity were measured in the offspring. Significant delays were noted in the development of the righting reflex at 5 and 50 ppm and in eye opening at 50 ppm. No difference was observed in development of the startle reflex at either dose. Mean body weights of treatment groups during this developmental period were not significantly different from controls. Locomotor activity was measured in adult males utilizing a residential maze. Both levels of lead produced a significant reduction in locomotor activity. When groups were treated with d-amphetamine (4.0 mg/kg subcutaneous), lead treatment caused a dose-related diminution in the amphetamine-induced hyperactivity. These results indicate that rats exposed to low levels of lead from conception until adulthood show a delay in nervous system development. As adults, these animals exhibit hypoactivity and decreased responsiveness to amphetamine.

Aging↗