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Biomedical subjects

G E Burdick

Publications and source records attributed to G E Burdick.

18 recordsLinked to original sources

Microscopic transduodenal sphincteroplasty and transampullary septoplasty for papillary stenosis.

Recurrent, severe, and intractable symptoms of right upper quadrant abdominal pain without a clear cause are extremely frustrating to patients and their physicians. This study examines the use of strict preoperative criteria utilizing endoscopic retrograde cholangiopancreatography, strictly defined clinical symptoms, and laboratory values to identify patients with hepatobiliary or pancreatic pain resulting from abnormalities of the papilla of Vater and the duct of Wirsung. Microscopic sphincteroplasty techniques stressing complete transection of the muscular transampullary septum have been incorporated with strict preoperative screening criteria to produce significantly improved long-term results (p greater than 0.005). Sixty-eight percent of 81 highly selected patients with at least a 6 month follow-up reported good results. Ninety-four percent claimed the procedure was definitely of benefit.

Abdomen

Clinical spectrum of pseudomembranous colitis.

Five cases of pseudomembranous colitis (PMC) provided the opportunity for observation of clinical, endoscopic, and histologic features, and evaluation of potential modes of therapy. Although PMC may occur postoperatively or concomitantly with staphylococcal infection, if most frequently occurs following the administration of a variety of antibiotics. Patients with this disorder often have chronic, debilitating diseases. The clinical course may vary from a self-limited diarrheal illness to a fatal process. Onset with abdominal pain, diarrhea, and fever is characteristic. Barium enema contrast findings are nonspecific. Proctoscopy usually permits an accurate diagnosis. In the typical case, multiple elevated nodules formed by cream-colored plaques of pseudomembrane are scattered about the inflamed mucosa. Biopsy of these nodular lesions will confirm the diagnosis. Therapy must be individualized.

Adult

Acute colitis resembling ulcerative colitis in the hemolytic-uremic syndrome.

The case report of a 10-year-old boy, admitted to the hospital after he had experienced 4 days of periumbilical abdominal pain, intermittent vomiting, and diarrhea, is presented. He had proctoscopic and radiologic findings resembling ulcerative colitis. However, further analysis of laboratory data suggested hemolytic-uremic syndrome. Since the patient in the pediatric age group presents with a clinical picture mimicking ulcerative colitis, this hemolytic-uremic syndrome should be included in the differential diagnosis. Examination of a peripheral smear revealing typical findings of microangiogpathic, hemolytic anemia, thrombocytopenia, and a rising blood urea nitrogen value will lead to the diagnosis of hemolytic-uremic syndrome and early appropriate therapy.

Child