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Biomedical subjects

G E Foley

Publications and source records attributed to G E Foley.

At least 37 records · Page 2Linked to original sources
PubMed1970

Growth characteristics of virus-transformed cells. Maximum population density, inhibition by normal cells, serum requirement, growth in soft agar, and xenogeneic transplantability.

Virus transformants (like cancer cells, cells transformed by X-ray or carcinogens, or those which have transformed spontaneously) exhibit a number of phenotypic changes which are usually associated, and which may be lost concurrently. That association is, however, not invariable. More particularly, the altered characteristics here studied (escape from contact inhibition of growth and susceptibility to inhibition by other cells, decreased serum requirement, and ability to grow in soft agar) do not, in and of themselves, endow the cell with the capacity to produce a tumor, at least as judged by the methods of assay here used. Although the question as to whether the tumorigenicity of virus transformants is causally linked to any of these associated changes cannot be answered definitively, the evidence suggests a close linkage, rather than identity, between the determinants of oncogenicity and the other properties here studied.

Adenoviridae↗
PubMed1970

Homologies in amino acid composition and structure of histone F2al isolated from human leukaemic cells.

Histones F2al extracted from normal and neoplastic cells possess similar amino acid compositions. Tryptic and chymotryptic peptides of the F2al histones have identical chromato-electrophoretic R(F) values. It is concluded that histones F2al from various sources have similar overall structures. The observed differences in the ratios of in-N-monomethyl- and di-in-N-methyl-lysine in the histones from normal and neoplastic cells may be of significance with respect to gene regulation.

Amino Acids↗