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Biomedical subjects

G E Geslien

Publications and source records attributed to G E Geslien.

6 recordsLinked to original sources
PubMed1985

Transillumination in breast cancer detection: screening failures and potential.

This prospective study of 1265 women referred to a multimodality breast diagnostic center compares the sensitivity for breast cancer detection of state-of-the-art transillumination light scanning and film-screen mammography. Of 33 biopsy-proven cancers, transillumination light scanning detected 58%, while mammography detected 97% of the cancers. Light scanning did detect 55% of the nonpalpable breast cancers, and 30% of those tumors smaller than 1 cm. Detection of breast cancer by light scanning was affected by breast size, but not architecture, and was directly related to tumor size. Although transillumination light scanning can detect some small curable breast cancers (smaller than 1 cm), it does not do so at a sensitivity adequate for screening. An example is illustrated in which light scanning detected an occult breast cancer before the development of recognizable mammographic changes.

Adult↗
PubMed1976

The sensitivity and specificity of 99mTc-sulfur colloid liver imaging in diffuse hepatocellular disease.

The sensitivity and specificity of 99mTc-sulfur colloid liver-spleen imaging in diffuse hepatocellular disease and the significance of image patterns found in these diseases are presented. By visually quantifying the image alterations found in biopsy-proven cases of diffuse hepatocellular disease and analyzing the correlation between the histological diagnosis and the quantified image alteration (individually and by groups), the 99mTc-sulfur colloid liver-spleen image was found to be highly sensitive (83%). Relative discriminatory values were derived for each image finding and a specific image pattern was found in cirrhosis.

Colloids↗
PubMed1976

Early detection of stress fractures using 99mTc-polyphosphate.

Clinical experience with 99mTc-polyphosphate scintigraphy in more than 200 patients with suspected stress fractures is presented. Stress fractures occur in bone which has been weakened as a result of accelerated physiological change induced by excessive muscular and mechanical activity. Unlike traumatic fractures, they are not accompanied by radiographic abnormality early in their course. Bone scintigraphy is sensitive enough to detect the physiological alterations found in stress fractures and was responsible for decreased morbidity in this series of patients due to early diagnosis.

Adolescent↗
PubMed1975

Abnormal radionuclide deposition patterns adjacent to focal skeletal lesions.

A scintigraphic pattern is described for bone scans with 99m-Tc-polyphosphate and 99m-Tc-diphosphonate in which abnormal tracer accumulation extends beyond the known limits of certain skeletal lesions. The associated pathologic entities include benign and malignant tumors, infection, and trauma. The pathogenesis of "extended patterns" has not been proved but probably relates to regional hyperemia induced by associated lesions. Increased blood flow results in more tracer delivery to otherwise normal bone in the "watershed" areas of hyperemia, producing these patterns.

Bone Diseases↗
PubMed1974

Pitfalls in Tc99m polyphosphate skeletal imaging.

The quality of Tc-PP scans is best in younger patients. In all age groups quality is adversely affected by free TcO4-. This should be suspected if excessive background is present or marked accumulation is noted in the thyroid gland. Direct physician supervision of all studies is recommended. Symptomatic and roentgenographically positive areas may then be determined for special interpretative attention. Objects which attenuate activity should be removed or noted. Potential sources of superficial contamination (product spill, urine, saliva) must be known and considered when extraneous activity does not correlate with skeletal structures or clinical findings. Normal variations in skeletal uptake of Tc-PP include asymmetries between periarticular areas on the right and left, local increases due to physiologic calvarial thickening and uptake in persistently visualized sternal ossification centers. Apparent variations in the vertebral activity may be due to focal plane effects of rectilinear scanners. Hyperemia can cause diffusely increased Tc-PP localization in an entire extremity. This effect may completely obscure a lesion or obscure the extent of a lesion. Tc-PP excretion through the kidneys occasionally provides useful morphologic or functional information concerning the urinary tract which should be inspected on all scans. Abnormal soft tissue uptake occurs in a variety of conditions including healing wounds and some malignant tumors. A large percentage of patients over 40 years of age demonstrate localization of Tc-PP in the walls of the femoral vessels.

Adolescent↗