Biomedical subjects

G E Johns

Publications and source records attributed to G E Johns.

3 recordsLinked to original sources

PubMed1988

Levobunolol and betaxolol. A double-masked controlled comparison of efficacy and safety in patients with elevated intraocular pressure.

In a double-masked, randomized, controlled clinical trial, the authors evaluated the ocular hypotensive efficacy of twice-daily treatment with levobunolol (0.25 and 0.5%) and betaxolol (0.5%) in 85 patients with open-angle glaucoma or ocular hypertension. During the 3-month study, intraocular pressure (IOP) reductions in the two levobunolol groups were significantly greater than in the betaxolol group. From a mean baseline IOP of approximately 25 mmHg, overall mean reductions were 6.2 and 6.0 mmHg for the 0.25 and 0.5% levobunolol groups, respectively, and 3.7 mmHg for the betaxolol group. No clinically or statistically significant among-group differences were noted in the systemic safety variables evaluated. These data suggest that although all three treatments are effective, levobunolol provides a greater reduction in IOP than betaxolol.

Betaxolol↗

PubMed1979

Combined trabeculectomy and cataract extraction.

We performed combined trabeculectomy-cataract extraction in 37 eyes of 29 patients. Average follow-up was 23.7 months. Thirty-three (89.2%) of the 37 eyes were controlled with much improvement postoperatively. A total of 35 eyes (94.6%) were controlled postoperatively; 22 eyes (59.5%) required no medications postoperatively. No greater incidence of complications with the combined procedure from that expected with cataract extraction alone was evident, except for four flat or shallow chambers and four hyphemas, none of which appeared to have an adverse effect on the final outcome of the surgery. We believe that the combined trabeculectomy-cataract extraction is a valid and safe procedure, if not the procedure of choice, in our hands, for the patient with coexisting cataract and glaucoma, and the advantages of the greater pressure control with the single procedure outweight the small increase in the risks of the surgery.

Adult↗

PubMed1979

Clinical evaluation of the DBR A-scan unit.

One hundred and eight eyes of 106 patients were evaluated preoperatively with the DBR-300 A-scan ultrasonic instrument. Intraocular lens power was then calculated using the formula supplied with the instrument, and the accuracy of the instrument was evaluated. It was found that 61.1% of the eyes were within +/- 1.00 D of the calculated refractive error and 81.5% of the eyes were within +/- 1.50 D of the calculated refractive error when using a standard 3.5-mm anterior chamber depth. Various factors were then analyzed to determine which factors contributed to the inaccuracy of the instrument. No single factor could be found to account for the slight tendency toward myopia, although several were found to contribute. No single factor was found to contribute to large errors.

Adult↗