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Biomedical subjects

G E Lees

Publications and source records attributed to G E Lees.

At least 37 records · Page 2Linked to original sources
PubMed1984

Lipogranulomatous lymphangitis in canine intestinal lymphangiectasia.

Lipogranulomatous lymphangitis of the intestine occurred in four dogs with intestinal lymphangiectasia. All four presented with chronic diarrhea; three had ascites and two had hypoalbuminemia. Lipogranulomas appeared in lymphatics, often at the point of mesenteric attachment, of small intestine, ileum, or ileum and colon. Mesenteric lymphatics were obstructed and villous lacteals were distended. Mesenteric lymph nodes of one dog contained large lipid spaces and that same animal had a solitary subcapsular lipogranuloma of the liver. This disorder is one of several that result in protein-losing enteropathy in dogs.

Animals↗
PubMed1983

Simultaneous cystometry and uroflowmetry for evaluation of micturition in two dogs.

A recently developed urodynamic testing procedure was used to evaluate disorders of micturition in 2 dogs. The procedure simultaneously recorded intravesical pressure and urine flow during micturition. In an 11-year-old spayed female Sheltie that could not urinate normally, a micturition study demonstrated functional outflow obstruction of the urinary bladder. Although the urethra was patent, the urethral resistance factor, as calculated from pressure and flow data, was extremely high during voiding efforts. A urethral transitional cell carcinoma along with secondary infection, inflammation, and fibrosis were found to be responsible for the dog's problem. Ability to urinate was restored following removal of the affected portion of the urethra. In a 6-year-old spayed female Doberman Pinscher with urinary incontinence during sleep, a micturition study demonstrated urethral incompetence. During infusion of 0.9% NaCl solution into the bladder, the fluid flowed through the urethra before the detrusor muscle contracted, and urethral resistance during voiding was low. The dog's incontinence was responsive to estrogen administration.

Animals↗
PubMed1983

Simultaneous cystometry and uroflowmetry (micturition study) for evaluation of the caudal part of the urinary tract in dogs: studies of the technique.

A procedure similar to one used for urodynamic evaluation of persons was adapted for simultaneous cystometry and uroflowmetry in dogs. Percutaneous transabdominal urinary bladder catheterizations were used for bladder infusion and cystometry, so that urine flow during voiding would not be altered by urethra instrumentation. The technique was evaluated twice in each of 12 healthy dogs (6 males and 6 females). Studies of individual dogs were performed 1 week apart. Comparisons were made between xylazine and oxymorphone for sedation to accomplish the procedure. Although the 2 drugs provided adequate sedation, oxymorphone was unsatisfactory because it interfered with micturition, whereas xylazine generally did not. Adverse consequences of the procedure occurred infrequently and were minor. According to results of urinalyses, hematuria or pyuria, or both, appeared during the week after the procedure was done in a few dogs, and staphylococcal bacteriuria was induced in 4 dogs. Fluid leakage from urinary bladders was not demonstrated by abdominal paracentesis immediately after each procedure or by contrast radiography performed the day after the 2nd study for each animal. Micturition studies were concluded to be reasonably safe to do, especially when performed by experienced individuals. The studies were judged to have considerable potential value as a means to evaluate lower urinary tract function in dogs.

Anesthesia↗
PubMed1983

Simultaneous cystometry and uroflowmetry (micturition study) for evaluation of the caudal part of the urinary tract in dogs: reference values for healthy animals sedated with xylazine.

Micturition studies were performed in 12 healthy dogs (6 females and 6 males). The animals were sedated with xylazine given either IV (1.1 mg/kg) or IM (2.2 mg/kg). Separate antepubic catheters were used to perform bladder infusions and record intravesical pressures. Instantaneous urine flow measurements were obtained, using an apparatus specially designed and constructed for small animals. A total of 45 simultaneous cystometric and uroflowmetric recordings were obtained, and numerical values for 16 different micturition variables were tabulated. The variables were analyzed separately on the basis of sex of the animal, route of administration of the sedative, and the fact of having had a previous bladder instrumentation-micturition study performed. Significant differences within individual dogs were not seen in these analyses. Intravesical pressures, urine flow rates, compliances, and urethral resistance were significantly different (P less than 0.05) between male and female dogs. The micturition study was a simple and reliable urodynamic testing method that could be clinically useful in dogs. In contrast to urodynamic tests previously described in veterinary medicine, this method provided evaluation of the bladder and urethra as a functional unit during both the filling and the emptying phases of micturition. A micturition study should not be regarded as an absolute measure of the physiologic activity of the caudal part of the urinary tract. However, it can provide important additional information for clinical assessment when the lower part of the urinary tract is affected by disease, injury, or drugs.

Animals↗
PubMed1982

Disseminated necrotizing panniculitis and pancreatic nodular hyperplasia in a dog.

An 8-year-old female Poodle had severe necrotizing skin disease characterized by numerous large red-purple, nonpruritic lesions. The larger lesions had soft, intensely discolored centers that contained sterile viscous blood-tinged material. Biopsies of the lesions revealed necrotizing panniculitis (subcutaneous fat necrosis). The dog did not respond to intensive therapy and euthanasia was performed. Necropsy findings included diffuse fat necrosis and pancreatic nodular hyperplasia. A pathoetiologic relation between pancreatic disease and diffuse fat necrosis in this dog was suggested.

Animals↗
PubMed1980

A bleeding disease (von Willebrand's disease) in a Chesapeake Bay Retriever.

A bleeding disease similar to von Willebrand's disease in man was diagnosed in a 6-month-old Chesapeake Bay Retriever with recurrent, protracted gingival hemorrhage that responded rapidly to fresh, whole blood transfusions. The dog had a prolonged bleeding time and low plasma factor VIII coagulant activity (18%). The plasma had no detectable factor VIII-related antigen or von Willebrand factor, as measured by ristocetin-cofactor and polybrene-cofactor activities. The dam of the dog had a plasma factor VIII-related antigen concentration (32%) well below the normal range. The antigen in the sire's plasma was at the low end of the normal range, as was the polybrene-cofactor of both the sire and the dam. These data suggested an inherited basis for von Willebrand's disease in this dog.

Animals↗
PubMed1980

Adverse effects caused by polypropylene and polyvinyl feline urinary catheters.

Effects of 3 days of open dwelling urethral catheterization were evaluated in normal male cats. Commercially manufactured polypropylene and polyvinyl feline urinary catheters of sufficient length to permit constant urine drainage were compared. Catheters were similar in length, diameter, and design. Hematuria occurred in 6 of 6 cats with polypropylene catheters and in 4 of 6 cats with polyvinyl catheters. For cats with polypropylene catheters, hematuria began within 24 hours of catheter insertion. Hematuria induced by polypropylene catheters was usually more severe in final urinalyses than that induced by polyvinyl catheters. Catheter-induced bacteriuria was found in 5 of 6 cats with polypropylene catheters and in 3 of 6 cats with polyvinyl catheters. Staphylococci and streptococci were the most common bacterial isolates. Microscopic lesions in urethras and bladders were significantly less severe in cats with polyvinyl catheters than cats with polypropylene catheters. With few exceptions, urethras of cats with polyvinyl catheters were microscopically indistinguishable from urethras of noncatheterized cats. Polypropylene catheters consistently induced urethritis which was most severe in some bacteriuric cats. Severe lesions were found in the bladders of all cats with polypropylene catheters. Bladder lesions were common in cats with polyvinyl catheters, but were usually less severe in cats with polypropylene catheters. There was no apparent relation between bacteriuria and bladder lesions.

Animals↗
PubMed1979

Anemia and osteopetrosis in a dog.

A 1-year-old, male Australian Shepherd Dog with consanguineous parents was discovered to have severe nonregenerative anemia associated with osteopetrosis. Diagnosis of the bone abnormality was established by skeletal radiography and microscopic examination of a rib biopsy specimen. The anemia was attributed to failure to develop normal marrow cavities combined with failure of extramedullary erythropoiesis. Although blood transfusions sustained the dog's life for 15 months, the dog died of a hemolytic transfusion reaction.

Anemia↗
PubMed1979

Fatal thrombocytopenic hemorrhagic diathesis associated with dapsone administration to a dog.

Dapsone was given for six days to a dog with chronic skin disease. The dog then became weak and anorectic, and it vomited and had purpura caused by severe thrombocytopenic hemorrhagic diathesis. Despite treatment, the dog died a week later. There were clinical and pathologic evidence that the dog's platelets and megakaryocytes had been destroyed during the first few days of dapsone therapy. It was concluded that the syndrome was dapsone-induced and that thrombocytopenia should be considered among the adverse reactions to dapsone in the dog.

Animals↗
PubMed1979

Spina bifida in the dog.

Spina bifida was diagnosed in four English Bulldogs and one Collie dog. These cases and the examination of records from the Veterinary Medical Data Program suggested a high incidence of spina bifida in the English Bulldog. Urinary and fecal incontinence was the most common reason for initial examination for the five dogs. Radiographs and myelography confirmed the diagnosis of spina bifida. Blood, cerebrospinal fluid and urine analyses did not aid diagnosis but urocystitis was identified. In addition to spina bifida, clinical signs and morphologic changes in the spinal cords of all five dogs fulfilled the criteria for an additional diagnosis of spinal dysraphism. A common pathogenesis for the two conditions is suggested.

Animals↗