Biomedical subjects
Publications and source records attributed to G E Lello.
In 39 denture-wearing patients in whom anterior maxillary flabby ridge tissue (prosthesis fibroma) was excised, 15.4% contained cartilaginous nodules within this tissue. The chondrometaplasia may arise due to mechanical irritation activating pluripotential mesenchymal cells; but the possibility that the cartilaginous nodules represent remnant embryologic tissue cannot be excluded.
The literature relevant to Stafne's mandibular lingual cortical defect is reviewed. Four case descriptions are added. Aetiological theories are discussed and an alternative hypothesis of circumscribed, localized bone atrophy due to relative ischaemia is proposed.
Three cases of gross craniofacial polyostotic fibrous dysplasia are presented, together with a brief review of the condition, and pertinent points regarding the cases are discussed. As complete excision of the lesion and immediate reconstruction is rarely feasible or possible, and partial excision may result in accelerated growth of the lesion during the patient's active growth phase, resection only to protect, maintain or restore certain important functions (e.g. vision) during this period are advocated, after which close follow-up is mandatory until the lesion becomes quiescent, when further surgical procedures may be undertaken.
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The ameloblastoma is a tumor arising predominantly in the mandible from odontogenic epithelium, and is locally invasive. It is rarely malignant; but even when benign, it causes gross local destruction and expansion of tissue. Growth is persistent, and recurrence may occur more than a decade after presumed total resection. Surgical resection should include a reasonable margin of healthy tissue whenever possible. Late patient presentation due to a paucity of symptoms, and insiduous tumor growth patterns render complete removal of the ameloblastoma difficult. Follow-up examinations should span a prolonged period, exceeding 10-15 years.