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Biomedical subjects

G E Levin

Publications and source records attributed to G E Levin.

32 records · Page 2Linked to original sources
PubMed1979

Leucocyte and erythrocyte magnesium levels after jejuno-ileal bypass surgery.

Leucocyte magnesium concentration was measured in 25 hypomagnesaemic patients following a jejuno-ilean bypass operation for gross obesity. The mean plasma magnesium concentration in the bypass group was 0.67 mmol/l compared with that of 0.90 mmol/l in a group of 17 healthy volunteers, but the leucocyte magnesium concentration in the two groups was not significantly different. The plasma potassium was found to be significantly lower in the bypass group but there was no significant difference in the leucocyte potassium concentration in the two groups. Simultaneous measurements of erythrocyte magnesium, sodium and potassium were made. There was no evidence of intracellular magnesium depletion on the basis of the tissues studied.

Calcium↗
PubMed1977

Leucocyte intracellular pH in patients with the metabolic acidosis of renal failure.

1. Human leucocytes were isolated from venous blood and resuspended in the subjects plasma. 2. Intracellular pH measurements were made in vitro by the dimethyloxazolidinedione technique in 13 healthy subjects and in 11 subjects with renal failure and metabolic acidosis. 3. The intracellular pH of the healthy subjects was found to be 7-07 (SD 0-04), significantly lower than that of the patients, which was 7-11 (SD 0-03). For all estimations plasma PCO2 was maintained at approximately 5-5 kPa. The methodological and possible metabolic reasons for this difference in intracellular pH are discussed.

Acidosis↗
PubMed1976

The intracellular pH of human leucocytes in response to acid-base changes in vitro.

1. Viable human leucocytes were isolated from venous blood and suspended in artificial media. Intracellular pH measurements were made by the dimethyloxazolidinedione technique in conditions simulating "respiratory" or "metabolic" acid-base disturbances. 2. Normal intracellular pH was 7-11 +/- 0-02 (mean +/- 2 SD) at an extracellular PCO2 of 5-8 kPa and a bicarbonate concentration of 25 mmol/l. 3. "Respiratory" and "metabolic" acidosis caused little change in pHi although increases in PCO2 led to relatively greater falls in pHi than did reduction in external bicarbonate concentration. 4. "Respiratory" and "metabolic" alkalosis caused similar and relatively greater increases in the pHi when compared with the response to an external acidosis.

Acid-Base Equilibrium↗
PubMed1972

Evaluation of the Lundh test in the diagnosis of pancreatic disease.

The Lundh test meal was administered to 32 normal subjects and 53 patients with suspected pancreatic disease. Tryptic activity was measured in the recovered duodenal juice. The level of activity distinguished the normal subjects from those with independently confirmed pancreatic disease, particularly chronic pancreatitis and carcinoma of the pancreas. The advantages and disadvantages of the test are discussed.

Hemochromatosis↗
PubMed1971

Radioselenium in duodenal aspirate as an assessment of pancreatic exocrine function.

A new test of pancreatic exocrine function is described in which radioselenium is measured in duodenal aspirate after an intravenous injection of (75)Se-selenomethionine and administration of a Lundh test meal. Duodenal (75)Se activity gave good separation between normals and subjects with disease of the exocrine pancreas and correlated well with trypsin levels in the aspirate.

Bile↗