Biomedical subjects
Publications and source records attributed to G E Morfill.
Measurements of effective structural (pair correlation function) and transport (diffusion constant) characteristics of the system of microparticles in dc and rf gas-discharge plasmas under microgravity conditions are reported. The comparison between these measurements and numerical simulations is used for complex plasma diagnostics.
Scattering in the attractive screened Coulomb (Yukawa) potential in the limit of strong interaction is investigated. It is shown that the scattering occurs mostly with large angles. The corresponding momentum-transfer cross section is calculated. The results are applied to estimate the ion drag force acting on an isolated micron-sized grain in low-pressure bulk plasmas.
A self-consistent theory of linear waves in complex laboratory plasmas containing dust grains and negative ions is presented. A comprehensive model for such plasmas including source and sink effects associated with the presence of dust grains and negative ions is introduced. The stationary state of the plasma as well as the dispersion and damping characteristics of the waves are investigated. All relevant processes, such as ionization, diffusion, electron attachment, negative-positive ion recombination, dust charge relaxation, and dissipation due to electron and ion elastic collisions with neutrals and dust particles, as well as charging collisions with the dusts, are taken into consideration.
The first experiment on the decharging of a complex plasma in microgravity conditions was conducted. After switching off the rf power, in the afterglow plasma, ions and electrons rapidly recombine and leave a cloud of charged microparticles. Because of microgravity, the particles remain suspended in the experimental chamber for a sufficiently long time, allowing precise measurements of the rest particle charge. A simple theoretical model for the decharging is proposed which agrees quite well with the experiment results and predicts the rest charge at lower gas pressures.
It is shown that a nonlinear temperature distribution in gas discharge plasma leads to a specific low-frequency mode of a quasi-two-dimensional plasma crystal. Linear dispersion characteristics of the mode are obtained. The characteristics of the mode can depend strongly on the temperature gradients and therefore can be effectively controlled by the experimental conditions.
This study deals with the boundary between a normal plasma of ions and electrons, and an adjacent complex plasma of ions, electrons, and microparticles, as found in innumerable examples in nature. Here we show that the matching between the two plasmas involve electrostatic double layers. These double layers explain the sharp boundaries observed in the laboratory and in astrophysics. A modified theory is derived for the double layers that form at the discontinuity between two different complex plasmas and at the point of contact of three complex plasmas. The theory is applied to the first measurements from the Plasma Kristall Experiment (PKE) Nefedov Laboratory in the International Space Station.
The problem of calculating the ion drag force in complex plasmas is considered. It is shown that the standard theory of Coulomb scattering usually fails for the ion-dust elastic collisions. A simple approach to extend this theory is proposed. This leads to a considerable enhancement in the ion-dust elastic scattering cross section and, hence, increases the ion drag force in comparison with the previous analytical results. Analysis shows that the ion drag usually exceeds the electrostatic force in the limit of weak electric field. We suggest that this is the cause of the central "void" observed in microgravity complex plasma experiments.
Coagulation of charged particles was studied using the mean-field Smoluchowski equation. The coagulation equation was generalized for the case of a conserved system of charged particles. It was shown that runaway cluster growth (gelation) solutions exist if the charge-dipole (induced) interaction of clusters is included. When clusters are in thermal equilibrium with the ambient gas, the charge-dipole interaction dramatically enhances the aggregation process and considerably increases the likelihood of a gelation transition.
Micron-sized particles are suspended or lifted up in a gas by thermophoresis. This allows the study of many processes occurring in strongly coupled complex plasmas at the kinetic level in a relatively stress-free environment. First results of this study are presented. The technique is also of interest for technological applications.
An analytical two-dimensional model for weakly dispersive and weakly nonlinear longitudinal and transverse shear waves propagating in an ideal two-dimensional hexagonal Yukawa crystal is presented. The model takes into account the nonlinear terms up to the third order. Both compressional and shear soliton solutions are found in the long-wavelength approximation. It is shown that the compressional solitons are always supersonic and weakly anisotropic. The shear solitons, on the other hand, exhibit strong anisotropy and can be both subsonic and supersonic, depending on the direction of propagation. In the model, shear solitons cannot propagate along the main axes. The role of weak damping as well as formation of multiple solitons is analyzed. The results are discussed in connection with wave and Mach cone experiments in a monolayer hexagonal plasma crystal, and a diagnostic method is proposed to measure both the charge of the microparticles and the lattice parameter.
A laboratory experiment has been performed in which a temperature gradient is used to generate a large central void in a rf-generated complex plasma. Through the use of laser flashing techniques, two-dimensional velocity vectors have been obtained from particles falling from the top to the bottom of the void. These particles are used to generate a two-dimensional map of the acceleration, and consequently the net forces, that act upon particles in the void.
A dust void, i.e., the dust-free region in a dusty plasma, results from the balance of the electrostatic and plasma (such as the ion drag) forces acting on a dust particle. The properties of dust voids depend on the ratio of the void size to the mean free path of plasma ions colliding with neutral species of a weakly ionized plasma. For many plasma-processing and plasma-crystal experiments, the size of the void is much larger than the ion-neutral mean free path. The theory and numerical results are presented for such a collisional case including the situations in which the plasma is quasineutral in the void region or the plasma quasineutrality is violated, as well as the case in which the ion ram pressure is insignificant.
Microrods were levitated in the collisional sheath of a rf plasma. Rods below a critical length settle vertically, parallel to the electric field, while longer rods float horizontally. Usually rods with other inclinations spin about a vertical axis. These experimental features fit well with a model that includes a theoretical profile for the sheath, a plasma model for the screening length, which increases going deeper in the sheath, and a plasma theory for the charging of the rod's elements. Despite the agreement this paper highlights the need for a better understanding of the charging mechanism of bodies in sheaths and of the transition region in collisional sheaths.
An interaction of a negatively biased wire with a monolayer lattice of negatively charged particles has been studied experimentally. The particles levitated at the height of the wire in a sheath of an rf discharge. It was found that the particles close to the wire were repelled from it electrostatically, while the far particles were attracted due to the drag of the ion flow deflected toward the wire. The ion drag force prevails far from the wire, whereas the electrostatic force is stronger close to the wire. The range of the forces is one to two orders of magnitude greater than the screening length.
The scaling-index method (SIM) is a novel tool for image processing in scanning-probe microscopy. Originating from the theory of complex systems, the SIM can be used in order to extract structural information from arbitrary data sets. This method can readily be applied to the analysis of digital atomic-force microscopy (AFM) images. Especially for biomedical diagnostics, where genetic material is investigated by various microscopic methods, a reliable image segmentation based on the SIM algorithm is helpful. As a first application, AFM-images of GTG-banded human metaphase chromosomes (with G bands obtained by Trypsin using Giemsa) are compared with micrographs from conventional light microscopy by means of a scaling-index analysis. While the grey-level distributions of the optical and the AFM-images are largely different from each other, the scaling-index images are remarkably similar. Using this method, a fingerprint of an image can be produced which helps in the classification and interpretation of the measured data.
Experiments were carried out to investigate a three-dimensional (3D) plasma crystal. A method of determining the positions of each individual microparticle has been developed. A crystal volume of about 2x10(4) particles in 19 horizontal planes was analyzed. Direct imaging and the 3D pair correlation function show that "domains" of fcc and hcp lattices coexist in the crystal. Other structures, in particular, the theoretically predicted bcc lattice, were not observed.
Dusty plasmas in a gas discharge often feature a stable void, i.e., a dust-free region inside the dust cloud. This occurs under conditions relevant to both plasma processing discharges and plasma crystal experiments. The void results from a balance of the electrostatic and ion drag forces on a dust particle. The ion drag force is driven by a flow of ions outward from an ionization source and toward the surrounding dust cloud, which has a negative space charge. In equilibrium the force balance for dust particles requires that the boundary with the dust cloud be sharp, provided that the particles are cold and monodispersive. Numerical solutions of the one-dimensional nonlinear fluid equations are carried out including dust charging and dust-neutral collisions, but not ion-neutral collisions. The regions of parameter space that allow stable void equilibria are identified. There is a minimum ionization rate that can sustain a void. Spatial profiles of plasma parameters in the void are reported. In the absence of ion-neutral collisions, the ion flow enters the dust cloud's edge at Mach number M=1. Phase diagrams for expanding or contracting voids reveal a stationary point corresponding to a single stable equilibrium void size, provided the ionization rate is constant. Large voids contract and small voids expand until they attain this stationary void size. On the other hand, if the ionization rate is not constant, the void size can oscillate. Results are compared to recent laboratory and microgravity experiments.
A method using a parameter from the field of nonlinear dynamics to quantify the variability of ventricular premature complexes (VPCs) is presented. One hundred patients with coronary artery disease and > or = 10 VPCs/hour were included in the study. The RR intervals were plotted in a three-dimensional artificial phase space, and the structures in phase space were quantified by the local scaling indices, alpha. In the frequency distribution histogram, n(alpha), for each patient, the maximum of the ventricular ectopies alpha VPC, adjusted to the VPC frequency, was assessed; alpha VPC was used as the risk indicator. Endpoints were total mortality and sudden cardiac death. During follow-up (mean 3.1 years), 28 out of 100 patients died, 16 suddenly; alpha VPC had a significant prognostic impact and was independent from other risk indicators, such as left ventricular ejection fraction (LVEF). Patients who died during follow-up were characterized by a high alpha VPC. The optimal discrimination of high risk patients and low risk patients occurred at alpha VPC = 3.0. After 4 years, the survival rate of patients with a alpha VPC > 3.0 was 59%, in contrast to 97% in patients with alpha VPC < or = 0.3. As to the sudden death mortality, the survival rates were 74% and 97%, respectively. The difference between the groups were significant for both endpoints. Patients with an increased VPC variability (i.e., alpha VPC > 3.0) were at enhanced risk of sudden death and total mortality risk; alpha VPC was independent from other risk indicators such as the LVEF or heart rate variability parameters.