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Biomedical subjects

G E Pierard

Publications and source records attributed to G E Pierard.

At least 19 recordsLinked to original sources
PubMed1992

Endoscopic cure of a giant sacral meningocele associated with Marfan's syndrome: case report.

An unusual anterior sacral meningocele associated with Marfan's syndrome, with demonstrated dural anomalies related to Marfan's syndrome is reported. Endoscopy enabled complete exploration of the meningocele, its morphological description, and ultimate cure. The meningocele resembled an hourglass made up of intrasacral and anterior sacral components. The communication of this bilobed malformation with the dural sac was so small that only the intrathecal injection of a colored solution allowed its localization. The closure of this communication was accomplished under endoscopic view by a single stitch. The postoperative course of the patient was characterized by immediate disappearance of the preoperative clinical signs. Computed tomographic scans demonstrated progressive complete collapse of the anterior sacral meningocele and partial resolution of the intrasacral component. Dural anomalies of Marfan's syndrome are described, and their relationship to the formation of the meningocele is discussed.

Adult↗
PubMed1992

A comparison of intraperitoneal prostheses for the repair of abdominal muscular wall defects in rats.

We compared the tissue response to the intraperitoneal implantation of three different prostheses (Gore-Tex, Mersilène, Vicryl-Mersilène) used to repair abdominal wall defects in rats. Vicryl-Mersilène is a new experimental prosthesis made of Dacron (Mersilène) coated with absorbable polyglactin (Vicryl). The least amount of adhesions to omentum and gut was found with Mersilène. Gore-Tex was responsible for the accumulation of neutrophils rather than macrophages mostly collected in close contact with Mersilène and Vicryl-Mersilène. Fibrosis, evaluated by histology and computerized morphometry, was mostly found with Vicryl-Mersilène. This should allow a better incorporation of Mersilène and a tighter anchorage to the abdominal wall, after Vicryl resorption.

Abdominal Muscles↗
PubMed1991

Dendrocytoclasis in Henoch-Schönlein purpura.

We studied by immunohistochemistry the fate of factor XIIIa-positive dermal dendrocytes in Henoch-Schönlein purpura. We have observed apoptosis affecting most of the perivascular dendrocytes. Such an aspect of dendrocytoclasis has never previously been reported in inflammatory disorders in the absence of vasculitis.

Child↗
PubMed1990

Recessive metaphyseal dysplasia without hypotrichosis. A syndrome clinically distinct from McKusick cartilage-hair hypoplasia.

Among children with recessive metaphyseal dysplasia involving the knees and extremities, two types can be distinguished. In true cartilage-hair hypoplasia, as described by McKusick, many patients show clinical hair involvement and variable immunodeficiency. We present a series of six patients with the same radiological changes, but without apparent hypotrichosis. We suggest that they should be considered as having a variant form of cartilage-hair hypoplasia, with a clinically distinct phenotype, which could be as common as 'true' cartilage-hair hypoplasia among non-Amish populations. Microscopic examination of the hair may show reduction in the diameter of the hair shaft. This form of metaphyseal dysplasia may result from allelic heterogeneity.

Bone Diseases, Developmental↗
PubMed1990

[Immunohistochemistry and the sweat glands].

By using a series of antibodies, we studied the immunohistological hallmarks of eccrine and apocrine sweat glands. Antibodies raised against cytokeratins 6 and 18 decorated the eccrine glands except the acrosyringium. The anti-CEA Ab revealed a uniform and exclusive staining of the eccrine glands. The anti-cytokeratins 8, 18 and 19 Ab labelled the apocrine glands and the secretory part of the eccrine glands. The acrosyringia were revealed by anti-EMA Ab. The immunostaining with anti S-100 protein was positive for the secretory part of the eccrine glands.

Carcinoembryonic Antigen↗
PubMed1988

[Acute and chronic borreliosis transmitted by ticks in Europe].

Ticks are direct pathogenic agents, and also transmit some infectious diseases such as borreliosis. Clinical manifestations of borreliosis are multiple. They most often affect the skin, nervous system, joints and heart. Cutaneous pseudolymphomas, erythema chronicum migrans of Afzelius, acrodermatitis chronica atrophicans of Pick-Herxheimer, meningo-radiculitis and various arthropathies are the most commonly encountered diseases.

Acute Disease↗
PubMed1988

[Lobomycosis].

Lobomycosis is a rare disease occurring with predilection in the Amazonian region. We report the clinical and histological presentation of a patient living in Peru. The lesion resembled an hypertrophic scar located on the neck. It corresponded to a massive infiltration of the dermis by macrophages loaded with numerous Loboa loboi.

Dermatomycoses↗
PubMed1987

[Cutaneous hematopoiesis and myelofibrosis].

Cutaneous hematopoiesis occurring in adult life is a rare but specific manifestation of myelofibrosis. We report a case where the three components, i.e., myeloid, erythroid and megakaryocytic cells, were present in the dermis.

Aged↗
PubMed1986

How is the basement membrane attached to the dermis? Stereology of the interlacing fibers at the underface of the dermo-epidermal basement membrane.

A three-dimensional view of the underface of the dermoepidermal basement membrane is provided by scanning electron microscopy and correlated with aspects of optical and transmission electron microscopy. A thin network of interlacing fibers runs parallel to the basement membrane and appears to be attached to it from site to site through loops of anchoring fibers. A model of the attachment of the basement to the dermis is proposed.

Actin Cytoskeleton↗
PubMed1986

Massive lymphocyte-mediated apoptosis during the early stage of pseudopelade.

The early evolving lesions of the hair follicles are described in pseudopelade, a type of cicatricial alopecia where clues for the diagnosis of lupus erythematosus or lichen plano-pilaris are lacking. A sudden and synchronized cell death of all the cells of the epithelial sheaths of the hair follicles occurs and is associated with a dense infiltration by lymphocytes. The epidermis remains uninvolved. This unique aspect is most probably related to the mechanism of apoptosis. Its intensity and extension are much more pronounced than in lichen planus and in lupus erythematosus. Pathogenesis of at least some cicatricial alopecias could therefore be related to massive apoptosis without evident and close relationship with the classical etiologies, i.e. lichen planus and lupus erythematosus.

Alopecia↗