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G E Slater

Publications and source records attributed to G E Slater.

6 recordsLinked to original sources
PubMed1987

Evoked potentials to test a treatment of chronic multiple sclerosis.

Multimodal evoked potentials (EPs) were obtained serially in 57 patients with multiple sclerosis enrolled in a double-blind, controlled study of hyperbaric oxygen. We encountered drawbacks in the use of EPs in monitoring effects of a treatment for chronic multiple sclerosis. Limitations include a relatively arduous testing protocol and the significant occurrence of ambiguous and frankly unreproducible results. Test/retest variability is large in stable patients. There is poor correspondence between EP changes and changes of clinical function as well as among EP modalities. Whether EP measurements ultimately prove to be useful in testing new therapies awaits the development of a truly effective treatment, the effects of which can be shown despite these factors and limitations.

Brain↗
PubMed1986

Hyperbaric oxygenation and erythrocyte antioxidant enzymes in multiple sclerosis patients.

Erythrocyte glutathione peroxidase, catalase, and superoxide dismutase activities were measured in 18 patients with clinically definite MS, and results compared with those from neurological controls. These studies indicated that glutathione peroxidase activity in erythrocytes of MS patients was not different from that of the neurological controls. However, superoxide dismutase was lower in the MS patients compared to neurological controls. The effect of hyperbaric oxygenation on these erythrocyte enzymes in MS patient's was also investigated. Exposure of MS patients to 2 ata with either 10% O2 or 100% O2 had no effect on glutathione peroxidase activity. Comparison of each individual MS patient's pre- and post-treatment superoxide dismutase values indicated a significant increase after 100% O2. Similar examination of each individual's catalase activity indicated an increase after exposure to both 10% O2 and 100% O2 at 2 ata. These data suggest that erythrocyte enzyme response to oxygen stress does not involve changes in activity of all the antioxidant enzymes. Instead, only specific enzymes appear to be affected by HBO.

Adult↗
PubMed1979

Frequency-amplitude gradient: a new parameter for interpreting pediatric sleep EEGs.

We describe an EEG pattern in pediatric sleep records, called the frequency-amplitude gradient (FAG). This pattern is a progressive decrement in voltage from occipital to frontal areas, with an accompanying decrease in slow frequencies in the same posterior-anterior direction. We report the results of examining 100 sleep records of children between birth and 10 years of age, with a review of the clinical diagnoses. There is a positive correlation between the severity of illness and the presence or absence of FAG. Furthermore, acute illnesses appear to be associated with the transient loss of the FAG, and with its return to normal with clinical recovery. The presence or absence of a FAG should be incorporated into the criteria for determining the normality of pediatric sleep EEGs.

Brain↗
PubMed1978

Podophyllin poisoning. Systemic toxicity following cutaneous application.

The toxicity of topically applied podophyllin in a 16-year-old girl is presented. Coma requiring respiratory support and major neurologic complications as well as hematologic and hepatic toxicity was observed. Therapy with a new modality, charcoal hemoperfusion, resulted in resolution of the acute toxicity, leaving a peripheral neuropathy which had not completely resolved after 4 months. The pharmacology and suggested treatment measures for the toxicity of this rarely reported agent are reviewed.

Administration, Topical↗