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Biomedical subjects

G E Sowton

Publications and source records attributed to G E Sowton.

13 recordsLinked to original sources
PubMed1990

Acceleration of conduction within an accessory pathway with propafenone.

We describe a case of dangerous acceleration of conduction through an accessory pathway produced by the Class IC agent propafenone during routine electrophysiological study of a patient with Wolff-Parkinson-White syndrome. This pro-arrhythmic effect has not previously been described with this drug. Propafenone is now being more widely used since the publication of the preliminary results of the CAST Study in the U.S.A.

Adult↗
PubMed1975

Surgical treatment of ventricular tachycardia after epicardial mapping studies.

Two patients with intractable life-threatening ventricular tachycardias have been studied using intracardiac electrograms and programmed electrical stimulation of the heart. Both patients have shown to have an underlying re-entry mechanism in the ventricles as the basis for the tachycardias. Both patients underwent epicardial mapping studies at cardiac surgery, and the site of re-entry was established. In one patient the re-entry front was found to start in the posterobasal region of the left ventricle and in the other patient the re-entry front was found in the anterobasal region of the right ventricle. In both patients surgical interruption of the re-entry front was carried out. Both patients are alive and free from tachycardias at the time of writing.

Adult↗
PubMed1975

Review of variations in origin of left circumflex coronary artery.

During the performance of 200 routine coronary angiograms, 5 patients with anatomical variants of the origin of the left circumflex coronary artery were found. The origin and course of the left circumflex coronary artery is described in each case. The practical importance of these variant vessels in patients being considered for coronary artery surgery is emphasized.

Angina Pectoris↗
PubMed1975

Haemodynamic events in right and left ventricle during angina induced by atrial pacing.

Atrial pacing to the point of angina or up to a maximum rate of 166/min was carried out in 37 patients during coronary angiography. In 9 patients with normal coronary arteries both the right and left ventricular end-diastolic pressures fell remained steady with increasing heart rate. The same response was observed in 14 patients with angiographically proven coronary artery disease. In the remaining 14 patients with provencoronary artery disease the end-diastolic pressure in the left ventricle rose at the point when the patient experienced angina. In 10 of this latter group there was a simultaneous rise in the right ventricular end-diastolic pressure. In 4 patients the rise in end-distolic pressure was seen in the left ventricle only. The haemodynamic events in the right ventricle during angina appeared in most cases to mimic the events occurring in the left ventricle. There was no correlation between the angiographic findings and the changes in end-diastolic pressure in the two ventricles during angina.

Angina Pectoris↗