[Osteonecrosis following TEP (total endoprosthesis) exchange, intraoperative femur fracture and multiple cerclages].
Explore the source record for details and available documents.
Aged↗
Biomedical subjects
G Edel
Publications and source records attributed to G Edel.
[Acute fatty liver in pregnancy].
Explore the source record for details and available documents.
Acute Disease↗
Mechanism of liver-specific metastatic tumor spread in a murine tumor model.
Malignant tumors frequently show an organ-specific metastatic spread, the causes of which are still largely unknown. Using an experimental tumor model, a methylcholanthrene-induced pleomorphic myofibrosarcoma ER 15-P of the C57Bl6J mouse, we wanted to find out whether this phenomenon is due to an adaptation or to a selection of tumor cells. After i.v. injection of tumor cells from the primary ER 15-P into the tail vein of male mice, metastases were regularly found in the lungs, mediastinal lymph nodes, and brain, as well as in the liver and kidneys, and occasionally in the adrenals. The following experimental procedures were used to isolate a tumor cell line with a possible liver preference: (1) Tumor cells from the primary ER 15-P were injected into a mesenteric vein of male mice. Tumor cells from the resulting liver colonies were again injected into the portal system of one group of mice. In a second group, part of the same cell suspension was injected into the tail vein. This procedure was performed four times. (2) Tumor cells from the primary ER 15-P were applied into the tail vein of male mice. Tumor cells from the resulting liver metastases were reinjected directly into the tail vein. This experiment was repeated three times. (3) Tumor cells from the primary ER 15-P were injected into the tail vein of male mice. Tumor cells from liver metastases were then injected, first, into the portal system of one group of male mice, and thereafter into the tail vein of another group of animals. This experiment was repeated twice. The following results were obtained: (1) By a repeated adaptation of tumor cells from the primary ER 15-P to liver tissue, no tumor cell line could be isolated that would show a preferential metastatic spread to this organ after tail-vein injection. (2) Repeated i.v. passages of tumor cells from liver metastases into the tail vein led to the selection of a tumor cell line with a tendency to liver metastasis. (3) Tumor cells selected from liver metastases induced via tail-vein injection showed, after a prolonged stay in the liver and a successive i.v. passage into the tail vein, a marked specificity for this organ. These results indicate that the liver-specific spread of tumor cells in our model is based on the selection of a tumor cell line from the primary ER 15-P influenced by the hepatic microenvironment.
Animals↗
The influence of the microenvironment of liver-specific tumor cell colonization in a murine tumor model.
UNLABELLED: Malignant tumors often show an organ-specific metastatic spread. Some cells of the primary apparently bear an affinity for growing in the microenvironment of certain organs. After i.v. injection of myofibrosarcoma cells from the primary ER 15-P into the tail vein of male C57/Bl6J mice, metastases developed in various organs. A tumor cell line (ER 15-Me3) isolated from liver metastases of the primary was found to colonize preferentially to the liver. To find out whether the liver specificity of the tumor cell line ER 15-Me3 depended on the hepatic microenvironment, tumor cells from this line were transplanted i.m. into the thighs of mice once (ER 15-Me3 i.m.1) or 5 times (ER 15-Me3 i.m.5), and then injected into the tail vein of mice. A part of the 5-times passaged tumor cell line was also injected into the mesenteric vein (ER 15-Me3 i.m.5-Me1) prior to reinjection into the tail vein. RESULTS: After i.v. administration of tumor cells from the first i.m. passage of the tumor cell line (ER 15-Me3 i.m.1) into the tail vein, the liver-specific metastatic behavior of tumor cells remained stable. Following the i.v. injection of tumor cells from the 5th i.m. transplant generation of the tumor cell line (ER 15-Me3 i.m.5) into the tail vein, organ distribution was similar to that of the primary. After only 1 mesenteric vein passage of the 5-times i.m. transplanted line ER 15-Me3 i.m.5-Me1 followed by i.v. injection into the tail vein, did tumor cells regain their liver-specific colonizing potential. Thus, the liver-specific tumor cell line seems to contain a small number of other tumor cell populations from the unselected primary. In the muscle, these tumor cells have a growth advantage over the liver-specific cells, while the latter will grow better in the liver. This indicates that the microenvironment may be one important factor influencing the organ-specific metastatic pattern of tumor cells.
Animals↗
[Tumorous space occupying lesions of the scapula. An analysis of preoperative assessment of invasion].
The radiographic and histological morphology of 38 tumors lesions of the scapula are analyzed. Osteochondromas (n = 12), chondrosarcomas (n = 7), plasmacytomas (n = 4) and Ewing's sarcomas (n = 3) were the most frequent neoplasms. The radiographically determined growth rates allowed an estimate of the dignity in all cases. Benign lesions were only observed in the first five decades of life, and were mostly located in the scapular blade. Most tumors found in the acromion and in the glenoid region and all lesions diagnosed in the 6th to the 8th decades of life were malignant. In 63.2% of cases correct diagnosis of the type of lesion present was possible on radiographic examination.
Adolescent↗
Rhabdomyosarcomatous component in dedifferentiated chondrosarcoma.
The case of a 57-year-old male is described with an extended bone tumor in the proximal left femur. The tumor is histologically classified as dedifferentiated chondrosarcoma. Immunohistologic examination revealed a strong positive reaction for desmin mainly in the tumor giant cells in the dedifferentiated areas, whereas chondroblasts in the low grade chondrosarcoma areas reacted negatively with desmin. In accordance with some cross striation in polymorphic tumor cells this points to a rhabdomyosarcomatous component in the dedifferentiated portions of the tumors. Thus, in addition to fibrosarcomatous, osteosarcomatous and malignant fibrous histiocytoma-like areas, our case presents another sarcomatous constituent in dedifferentiated chondrosarcoma.
Bone Neoplasms↗
[Neurofibromatosis and multiple nonossifying bone fibromas].
Three patients with a combination of neurofibromatosis and multiple non-ossifying fibromas are presented. All patients possessed multiple osteolytic lesions with sclerotic margins, resembling non-ossifying fibromas. Two patients showed similar lesions in additional localizations. In two patients, non-ossifying fibroma was histologically verified. The simultaneous occurrence of neurofibromatosis and multiple non-ossifying fibromas can possibly be put down to a generalized mesodermal dysplasia. However, the definite explanation is unknown.
Adolescent↗
Local myocardial and global ventricular function compared during positive inotropic medication.
The assessment of the pharmacological efficiency of cardiotonic drugs interferes with the complex force generation within the spatially netted myocardial meshwork. By multifocal local force and distance measurements we distinguished "afterloaded" from "unloading" force types, which essentially differ in their transient behaviour during changes in ventricular shape. Histologically we found the "afterloaded" force type in oblique fibre populations whereas the "unloading" force curve is generated in surface parallel fibres. Amrinon reduces pre- and afterload, thus inducing ventricular shrinkage. The resulting rearrangement of the intramural force pattern modifies the transmission of fibre tension to ventricular ejection in a way that contractility indices, derived from left ventricular pressure, become inapplicable. However, direct intracoronary drug injection, monitored by segmental force and distance measurements within the irrigated myocardial area, characterizes Amrinon as a potent positive inotropic drug.
Amrinone↗
Selection of liver-colonizing tumor cells from a murine fibrosarcoma induced by methylcholanthrene.
An experimental tumor model was developed to study the organ preference of malignant tumors. The primary tumor ER 15-P was induced by inoculation of 1 mg methylcholanthrene in 0.1 ml sesame oil into the left femoral muscle of a female C57/Bl6J mouse. The tumor was palpable 100 days after induction. Spontaneous lung metastases were found at autopsy on day 128. Serial IM transplantation of tumor cells from the primary ER 15-P resulted in pulmonary metastases in all male and female mice. After IV injection of tumor cells from ER 15-P to male mice, colonies were found in lungs, thoracic cavity, liver, kidneys and occasionally also adrenals; female mice sometimes had ovarian metastases in addition, but no hepatic metastases. Liver-colonizing tumor cells were selected in male mice as follows: (a) IV injection of tumor cells from primary ER 15-P; (b) removal of tumor cells from liver tumor nodules, reinjection into mesenteric vein; (c) preparation of resulting tumors in the liver, reinjection of these cells through the portal system in one group of mice, and IV administration into tail vein in another group: (d) IM inoculation of tumor cells of the mesenteric passage in the left gastrocnemius muscle of mice prior to IV injection via tail vein in another group. Steps c and d were repeated three times. The procedure resulted in a highly significant decrease of tumor cell colonization to lungs and other organs, and a preferential increase of liver colonization. The liver preference of cell lines thus selected was obvious. Possible mechanisms for the organ preference of malignant tumors are discussed.
Animals↗
Primary rhabdomyosarcoma of the leptomeninx. Clinical, neuroradiological and pathological aspects.
Report of an eight-year-old boy presenting with untreatable focal epilepsy and slowly progressing hemiparesis combined with personality changes. Continuous diagnostic efforts eventually resulted in the diagnosis of a primary intracranial rhabdomyosarcoma several months later. The delay in making the correct diagnosis was due to the fact that the malignant process originated as a diffuse involvement of the leptomeninx, and only in later stages a tumor mass developed. Nosology and histogenesis of primary intracranial rhabdomyosarcomas are discussed.
Arachnoid↗
The rare occurrence of a radiation-induced osteosarcoma in the clavicule after treatment of thyroid cancer.
The authors report on a postirradiation osteosarcoma of the clavicule in a patient treated for thyroid cancer. The total absorbed dose to the right clavicule was estimated 149 Gy (60 Co and 18 MeV elektron beam). The findings are demonstrated on plain radiographs, CT-scan and bone scintigraphy. The literature on this subject is reviewed and the possible pathogenesis discussed.
Adenoma↗
Ehlers-Danlos syndrome type VI: collagen type specificity of defective lysyl hydroxylation in various tissues.
The Ehlers-Danlos syndrome type VI is an inherited disorder of collagen metabolism characterized by a defective lysyl hydroxylase. The resulting lack of hydroxylysine has been found in several connective tissues, all of which show varying degrees of clinical symptoms. In the present study, collagen was isolated from different connective tissues and the degree of hydroxylation of lysyl residues was determined. Subsequently, collagen types I, II, III, IV, and V have been prepared from a number of tissues. Insufficient hydroxylation of lysyl residues was found in type I and type III collagen, whereas types II, IV, and V showed normal amounts of hydroxylysine. The expression of the defect, even for type I and type III collagen, varied widely from one tissue to another. A complete lack of hydroxylysine was observed in skin, while it was less pronounced in tissues such as bone, tendon, lung, or kidney. The data suggest the presence of several isoenzymes having varying affinities to the different collagen types.
Adult↗
[Comprehensive bronchitis therapy].
Explore the source record for details and available documents.
Aged↗
[Dissecting aneurysm--a rare but severe complication of pregnancy].
A case of aortic dissection at 37 weeks of gestation is presented with demonstration of angiographic and pathological findings. A review of clinical and pathological literature suggests, that rupture of aortic dissecting aneurysms occurs more frequently in women being pregnant than in non-pregnant women of the same age. Women with cardial malformations, coarctatio aortae, Marfan's syndrome and hypertension are at increased risk. Ultrasound scans of heart and thoracic aorta may lead to an early diagnosis in pregnancy. Intrauterine fetal asphyxia and death may be an early symptom due to partial obliteration of Aa. iliacae internae and ovaricae.
Adult↗