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Biomedical subjects

G Edner

Publications and source records attributed to G Edner.

32 records · Page 2Linked to original sources
PubMed1983

Nasal meningoencephalocele. A clinical problem.

Four cases of nasal meningoencephalocele are reported. They demonstrate the importance of considering the diagnosis of nasal glioma or meningoencephalocele in adults with a nasal polyp of atypical appearance, or in infants with nasal obstruction and unilateral nasal polyp. Misdiagnosed and incorrectly handled patients with nasal meningoencephaloceles may develop serious ascending infections and/or a constant CSF leak. A thorough radiological examination including conventional and computerized tomography of the anterior cranial fossa, isotope cisternography and CT-cisternography is advocated. A multi-disciplinary approach is recommended in the diagnosis and treatment. The surgical procedure includes an anterior fossa craniotomy often in combination with a transnasal approach.

Adult↗
PubMed1982

Positron emission tomography with 68Ga-EDTA in the diagnosis and localization of csf fistulas.

Five patients with cerebrospinal fluid (CSF) rhinorrhea were investigated with computed tomography (CT) and positron emission tomography (PET) to localize the site of a CSF fistula. After intrathecal injection of 10 MBq of 68Ga-EDTA, radioactivity was demonstrated in the basal cisterns. In three cases, the site of the fistula was visualized with PET. It is not always possible to demonstrate a CSF leakage with CT cisternography (CTC) using metrizamide, particularly in cases with minute fistulas or intermittent CSF rhinorrhea. With further experience and improved PET techniques, it may be possible to detect even very small fistulas.

Cerebrospinal Fluid Rhinorrhea↗
PubMed1981

Stereotactic biopsy of intracranial space occupying lesions.

The results of stereotactic biopsies of intracranial expanding lesions with narrow instruments both prior to and during the CT era are evaluated in 345 patients. Eighty-four cystic lesions were needled and roughly classified. Small, cystic, or solid tumours in anatomically well-defined areas such as the sellar, the third ventricle, and the pineal regions were as easily punctured and classified without as with CT scanning. When larger tumours in different compartments were punctured the biopsy verification rate increased from 55% towards 91% if an enhanced CT investigation was included. A stereotactic biopsy is a fairly safe procedure, yielding in this series a mortality less than 1% and a morbidity of 2.3%.

Adenoma↗
PubMed1980

DNA distribution in various parts of malignant gliomas assayed on stereotactic biopsies.

The study concerns the relation between the computerized tomogram, histopathology and DNA distribution in gliomas. The investigation was performed on stereotactic biopsies, which enabled the comparison to be made on a point-to-point basis. No clear-cut relation was found between histopathological grading and DNA distribution. In 1 patient diploid and aneuploid tissue was found in different parts of the tumor. In this case the difference in ploidy was mirrored by differences in histopathological grading and gross morphology as indicated by the CT scan.

Biopsy↗
PubMed1978

Stereotactic biopsies and computer tomography in gliomas.

This study was carried out in order to obtain data on the relation between tumour structures seen in computer tomograms and the corresponding histopathology and cytology. Nine consecutive patients were studied, and stereotactic biopsies were obtained from sites determined on contrast enhanced computer tomograms. Biopsies were obtained from tumour areas with high and low contrast uptake and from the low attenuating areas surrounding the tumours. The results indicated a close correlation between the microscopical morphology of gliomas and the pattern of the computer tomogram. Biopsy samples from low-uptake central areas contained tumour tissues, necrotic tissue, and in one case a cyst. Biopsies from high-uptake areas typically contained tumour tissue, whereas biopsies from low-uptake surrounding areas contained oedematous non-tumour tissue. For tumour diagnosis biopsies should be obtained from both low and high attenuating tumour areas.

Aged↗
PubMed1978

Redundant nerve roots of the cauda equina. A report of five cases.

Five personally examined cases of redundant nerve roots of the cauda equina are added to the 13 hitherto on record. Except for segmental neurological deficits, intermittent claudication-like symptoms of the cauda equina dominated the histories of four of our five cases. The diagnosis was confirmed at surgical exploration, which included laminal and dural decompression. At follow-up (two months--three years) the neurological deficit, or the intermittent claudication, or both, had improved in all our patients. The pathogenesis of root redundancy is obscure. It seems that the symptoms arise through the action of at least two factors viz compression of the spinal content and the existence of one or more redundant roots. Wider use of diagnostic aids and surgical exploration would probably show that redundant roots are more common than hitherto supposed.

Aged↗
PubMed1978

Stereotactic computer tomography for biopsy of gliomas.

A technique is introduced enabling automatic transfer of coordinates obtained at computer tomography into a stereotactic system previously applied in biopsies of brain lesions. Four to five biopsies from different parts of gliomas were taken to compare the structures demonstrated on computer tomography with the microscopic appearances. Of 45 biopsies in 13 patients, 36 were predicted correctly. This also served as an attempt to classify gliomas on the basis of their appearance in the CT image.

Adolescent↗
PubMedDate not supplied

Cerebrospinal fluid circulation: evaluation by single-photon and positron emission tomography.

Gamma camera cisternography after intrathecal administration of 111In-DTPA is a widely used and well established technique for studies of cerebrospinal fluid (CSF) circulation. The radiation dose from 111In, however, is a limiting factor that sometimes seriously affects the image quality and, hence, correct interpretation. This investigation was designed to assess the value of tomographic techniques for studies of CSF flow. Single-photon emission computed tomography (SPECT) was performed on 15 patients by means of the Karolinska Hospital rotating gamma camera system after injection of 111In-DTPA or 99mTc-DTPA. The combination of SPECT and 99mTc-DTPA proved to be a valuable technique. It permits a clear evaluation of the location of the isotope intracranially and its precise relation to the ventricles. Positron emission tomography (PET) applied after intrathecal administration of 68Ga-EDTA demonstrates that small amounts of radioactivity can be registered and that PET is a promising technique for the evaluation of CSF dynamics.

Cerebrospinal Fluid↗