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Biomedical subjects

G Enzmann

Publications and source records attributed to G Enzmann.

12 recordsLinked to original sources
PubMed2000

A comparison of nisoldipine ER and amlodipine for the treatment of mild to moderate hypertension.

This multicentre, double-blind, double-dummy, randomised trial compared the efficacy and tolerability of nisoldipine extended release (10-40 mg) and amlodipine (2.5-10 mg) in 161 patients. The primary end point was a between-treatment comparison of change from baseline to week 8 in mean office diastolic blood pressure (DBP). The least squares mean reductions in systolic (S)BP/DBP (+/- standard error) for nisoldipine and amlodipine were -11.7/-9.3 +/- 1.4/0.8 and -14.3/-12.0 +/- 1.4/0.8 mmHg, respectively. The DBP treatment difference was 2.7 mmHg (90% confidence interval: 1.1 to 4.3 mmHg; p = 0.005). Tolerability profiles were similar between treatments. The drug acquisition cost per mmHg DBP reduction was 40% lower with nisoldipine; an acquisition cost analysis revealed that amlodipine was 80% more expensive than nisoldipine for treating hypertension. In summary, nisoldipine and amlodipine provide clinically equivalent antihypertensive efficacy; however, nisoldipine is more economical than amlodipine.

Adult↗
PubMed1998

Analysis of oscillatory components of short-term heart rate variability in hemodynamically stable and unstable patients during hemodialysis.

Short period oscillatory components embedded in heart rate variability (HRV) were studied during hemodialysis induced hypovolemia in 15 hypotension-resistant (stable) and 15 hypotension-prone (unstable) patients. Hemodialysis was undertaken so that a similar blood volume reduction was induced in all patients (p > 0.05) without causing acute hypotension events. Autoregressive HRV power spectrums were calculated using an eigenanalysis-based approach. The frequencies of the main HRV rhythmic components were estimated through the Pisarenko harmonic decomposition. Percent changes during the hemodialysis in both heart rate and arterial pressure were similar in the stable and unstable groups (p > 0.05). The HRV spectral density showed markedly different power distributions. In the stable patients, power was mainly in the low frequency band (74+/-7 nU in the low frequency [LF] band vs. 21+/-6 nU in the high frequency [HF] band) whereas in stable patients, it was mainly in the high frequency band (39+/-10 nU in the LF band vs. 47+/-7 nU in the HF band). The frequency of the main oscillation was 0.1+/-0.02 Hz in stable patients and 0.18+/-0.04 Hz in unstable ones (p < 0.01). These HRV spectral parameters have a clear diagnostic value in discriminating between stable and unstable patients when their hemodynamic behaviors are similar.

Adult↗
PubMed1997

Autonomic nervous function during haemodialysis assessed by spectral analysis of heart-rate variability.

1. Short-term autonomic response to haemodialysis-induced hypovolaemia was studied in 30 patients undergoing chronic haemodialysis by analysing power spectra of heart-period variability. Patients were classified as haemodynamically stable (15 patients) and unstable (15 patients) according to their past history of cardiovascular collapse during the treatment. Blood volume, systolic arterial pressure and heart period were measured during sessions that ended without the occurrence of collapse. 2. No significant differences were observed when comparing blood volume, heart rate and arterial pressure of stable and unstable patients during the dialysis, and the two groups could not be distinguished merely on the basis of these haemodynamic parameters. Conversely, spectral analysis of beat-to-beat heart-period variability showed markedly different power patterns: in stable patients power was mainly in the low-frequency (LF) band (0.06-0.15 Hz), whereas in unstable patients it was mainly in the high-frequency (HF) band (0.15-0.4 Hz). 3. The efficiency of the autonomic response to hypovolaemia was evaluated by the ratio between the powers in the LF and HF bands. Stable patients exhibited an LF/HF power ratio systematically greater than unstable patients during the entire dialysis, and on the basis of this index the two groups were clearly separated. 4. Results obtained with spectral analysis lead us to conclude that reduced efficiency in the autonomic control of cardiovascular functions could be the main cause of the haemodynamic instability of patients prone to collapse.

Aged↗
PubMed1996

Parametric analysis of heart rate variability during hemodialysis.

The problem of evaluating short-term autonomic response to hypovolemia in patients under chronic hemodialysis treatment is considered. Power spectra of the beat-to-beat heart rate variability were evaluated during the dialysis treatment in twenty hemodynamically stable and unstable patients, using a parametric technique. The autoregressive model coefficients were calculated by the modified covariance method, while model order was selected according to the minimum description length criterion. Reported results demonstrate that stable and unstable patients present markedly different spectral patterns. The efficiency of the compensatory response to hemodialysis-induced hypovolemia was evaluated through the ratio between the powers in LF and HF bands. Stable patients exhibit a LF/HF ratio greater than one with large fluctuations over the whole dialysis session. In contrast, all the unstable patients are characterized by a value of LF/HF lower than one and with a reduced time variability. This result suggests that the hemodynamic instability of the hypotension-prone patients may be due to a deficiency in the short-term compensatory response to the hemodialysis-induced hypovolemia.

Algorithms↗
PubMed1995

Autonomic nervous function and blood volume monitoring during hemodialysis.

We studied the autonomic reflex response to hypovolemia during HD by means of spectral analysis of heart rate variability (SAHRV) in 10 hypotension prone (group A) and 10 hemodynamically stable patients (group B). UF rate normalized per total body water and blood volume fall were similar in the two groups. The sympatho-vagal balance index, calculated as the ratio between the integrals of the spectrum in the low (0.02-0.15 Hz) and in the high frequency range (0.2-0.35 Hz) rose in group B progressively from the beginning of the treatments, reaching a top at the 90th minute and remained subsequently high until the end. On the contrary this index did not show remarkable increases in group A. The differences between the two groups were statistically significant at 0 (4.6 +/- 2.9 vs 1.5 +/- 1.3), 60th (8.3 +/- 7.8 vs 2.2 +/- 2.6), 90th (17.9 +/- 13.4 vs 3.7 +/- 2.8), 150th (8.8 +/- 3.7 vs 2.7 +/- 2.8) and 210th minute (8.6 +/- 5.0 vs 2.9 +/- 2.5). In conclusion SAHRV shows an impairment of autonomic reflex response to hypovolemia in hypotension-prone patients.

Adult↗
PubMed1987

[Cytochemical determination of estrogen receptors in breast tumors].

An account is given in this paper of results obtained from determination of oestrogen receptors in cases of mammary tumours, using the FITC conjugate of Lee's cytochemical procedure. Minimum hardware input is required for the approach which is applicable also to smaller tumours and to cases of poor specificity. Carcinomas were positively recorded from 92 in 173 women, with 82.5 per cent of them exhibiting positive responses to oestrogen.

Adenocarcinoma, Mucinous↗
PubMed1983

Electron microscopic investigations on the location of rat liver ribosomal proteins S3a, S5, S6, S7 and S9 by means of antibody labeling.

The location of ribosomal proteins S3a, S5, S6, S7 and S9 on the surface of 40S subunits of rat liver ribosomes has been determined by means of antibody labeling and electron microscopy. Multiple antigenic determinants could be detected for proteins S3a, S6 and S7, whereas protein S9 shows only one and protein S5 two closely neighboured antigenic determinants. Antigenic determinants of proteins S3a, S6 and S7 have been mapped in the head and the body region of the 40S subunits. Protein S5 could be localized in the head and protein S9 in the body of the 40S subunits. These findings are discussed with regard to the location of functional sites on the 40S ribosomal subunit.

Animals↗
PubMed1979

Localization of proteins S1, S2, S16 and S23 on the surface of small subunits of rat liver ribosomes by immune electron microscopy.

Ribosomal proteins S1, S2, S16 and S23 were localized on the surface of the small subunit (40S) of rat liver ribosomes by immune electron microscopy. Antibodies against the single proteins were raised in rabbits and chicken and purified by affinity chromatography. 40S-IgG-40S complexes were obtained by incubation of 40S subunits with non-cross-reacting antibodies specific for each of the four proteins and subsequent sucrose density gradient centrifugation. The location of the proteins was determined by means of antibody binding sites visualized in negative contrast in the electron microscope. The four investigated proteins are mainly located in the head region of the small subunit. Exposed antigenic determinants of proteins S1 and S2 were found to be located at different sites of the small subunit whereas proteins S16 and S23 were mapped in a limited region only.

Animals↗