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G Espersen

Publications and source records attributed to G Espersen.

8 recordsLinked to original sources
PubMed1975

[A hypophysis-absces-syndrome in cattle. II. Pathomorphological investigations (author's transl)].

The clinical description (Espersen 1975) of a hypophysis-absces-syndrome in cattle is based on a retrospective analysis of 25 cases, which all were subjected to a patho-morphological examination after death or euthanasia. The post-mortem picture is characterized grossly by purulent, sero-fibrinous or serous inflammation of meninges, brain, cerebral ventricles, and pituitary region, with accumulation of pus in the pituitary region. The purlent inflammation in the pituitary region is often progressing intracranially but extradurally and involves adjacent cranial nerves, particularly the trigeminal and optic nerves. The extraneural viscera show chronic, embolic inflammatory processes in different organs in several cases as well as acute, agonal circulatory changes in the dead animals. A histological examination of selected parts of the brain and of the pituitary region from eleven of the cases shows in ten of these a protracted meningo-encephalitis and ventriculitis with gravitational extension to the basal meninges and the infundibulum of the hypophysis. The suppuration is further involving the pituitary cleft and adjacent parts of the pituitary (cf. fig. 1--6, 8--11). In one case only a large abces in teh adenohypophysis is found, without a concominant meningo-encephalitis (cf. fig. 7).

Animals↗
PubMed1975

[A hypophysis-abscess-syndrome in cattle III. Pathogenesis (author's transl)].

The pathogenesis of a hypophysis-absces-syndrome in cattle is discussed on the basis of clinical (Espersen 1975) and pathomorphological (Møller and Espersen 1975) investigations. It is concluded that several pathogenetic mechanisms are possible. A remarkable high incidence of the syndrome in recently ringed bulls point to the possibility of a porogenous spread from the nasal septum to the meninges and brain. The often occurring traumatic horn lesions with subsequent sinusitis suggest a porogenous spread from the sinus to the meninges and brain. On the other hand, traumatic horn lesions seem more often to occur as a secondary event and caused by automutilation, as a consequence of the pain, which is thought to accompany a primary meningo-encephalitis. The localization of the abscess in the hypophysis seems, in the majority of cases, to be a result of a primary, purulent meningo-encephalitis, with accumulation of pus from the brain ventricles to the infundibulum and pituitary cleft, due to gravitational forces. In some cases possibly as an extension from a basal meningitis. A direct, hematogenous metastasis to the frontal lobe of the pituitary is a further possibility. Ascending infection through a persistent cranio-pharyngeal duct and infection due to a primary cranial fracture represents other hypothetical, pathogentical possibilities. They have not been shown to occur. Severe clinical symptoms seem to be absent until the inflammation in the basal meninges and in the pituitary region attacks the adjacent cranial nerves, causing a paresis/paralysis.

Animals↗