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G F Atweh

Publications and source records attributed to G F Atweh.

39 records · Page 3Linked to original sources
PubMed1982

Intracranial solitary extraskeletal plasmacytoma resembling meningioma.

A patient had an intracranial solitary extraskeletal plasmacytoma (SEP). To date, only 12 similar cases have been reported in the English literature. This report includes the first description of computed tomographic findings in a patient with intracranial SEP. There is a striking similarity between the features of intracranial SEP and meningiomas. A detailed comparative study of the features of these two neoplasms was done. The findings indicate that the age and sex distribution, clinical features, location of the tumors, roentgenographic findings, and even the gross pathologic nature of the two neoplasms are very similar. The course and prognosis, however, are probably different. Intracranial SEP, although rare, should be included in the differential diagnosis of brain tumors that arise in areas where meningiomas commonly arise.

Adult↗
PubMedDate not supplied

Stathmin expression in immortalized and oncogene transformed cells.

Stathmin is a major cytosolic phosphoprotein that is highly expressed in leukemic cells and many other malignant cell types. The level of stathmin expression in a wide variety of cancer cells suggested that this phosphoprotein may play a role in the process of malignant transformation. We compared the levels of stathmin expression in low passage primary embryonic fibroblasts and in their immortalized counterparts. The immortalized cells had a markedly higher rate of proliferation that was associated with a four fold increase in the level of stathmin expression. In contrast, transformation of the immortalized fibroblasts with seven different activated oncogenes did not result in significant changes in the level of stathmin expression nor in a consistent increase in their rate of proliferation. These observations do not support a direct role for the activation of stathmin gene expression in the transformed phenotype. We suggest that the increased levels of stathmin in transformed cells compared to non-transformed cells may be a reflection of differences in their rate of proliferation and state of differentiation.

Animals↗