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Biomedical subjects

G F Ferraccioli

Publications and source records attributed to G F Ferraccioli.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Study of the effects of free radicals produced by ultraviolet rays on viscosity of human synovial fluid. Methodological details].

After having pointed out a method measurement of the synovial Fluid (S.F.) viscosity by means of a white blood cell diluting pipette, obtaining results similar to those of Ostwald's viscometer, the AA have studied the osteoarthrotic S.F. viscosity after Ultra Violet Illumination. The production of Free Radicals induced by U.V., determines a fall of osteoarthrotic S.F. viscosity towards the values found in arthritic S.F..So, the AA, indirectly, confirme the capacity of Free Radicals to induce a S.F. viscosity modification like that provoked by the phlogistic process.

Arthritis, Rheumatoid↗
PubMed1980

[Preparation of samples of biological fluids for electron spin resonance (ESR) examination].

The ESR (Electron Spin Resonance) Technique, is usually used in the study of Free Radicals and Metal - Proteins, in biological fluids, but the most apt method for the preparation of the sample has still to be defined. In this work the A.A. describe and analyse the negative and positive aspects of several methods. The results of the E.S.R. spectra, obtained by means of lyophilization, that is the most used method in literature, have been compared with those obtained by means of concentration of some biological fluid (serum and synovial fluid). The A.A. demonstrated that the lyophilization does not permit the reproducibility of the spectra, for different spectra are obtained from the same lyophilized serum and synovial fluid samples. A high reproducibility of the spectra is instead obtained by the concentration of the sample means of the "collodion bag" or "Aquacide" methods. The A.A. are convinced that for on exact investigation of the E.S.R. Signals, only the concentration method is useful, and not the lyophilization method as reported in literature.

Blood Chemical Analysis↗
PubMed1980

The effects of NSAID on monosodium-urate (MSU) skin test and on other in vivo skin tests (SK/SD; PHA).

The authors have pointed out a monosodium-urate (MSU) skin test in vivo, showing a practical usefulness in short-time evaluation of effects of non-steroidal antiphlogistic drugs (NSAID) in man; the isotopic curves, in the area of the skin test, reproduce those obtained in endogenous articular phlogosis. THe authors have studied, at the same time, the actions of NSAID on other skin tests (SK-SD; PHA) which reproduce, in earlier phases of cutaneous reaction, some aspects (erythema, thermographic values, isotopic curves) of 'immediators' phlogosis. The results show that the MSU skin test is more useful in studying the effects of NSAID for the feature of other skin test reactions are affected by many factors.

Anti-Inflammatory Agents↗
PubMed1979

[Cell-mediated immunity after blocking of the H2 lymphocyte receptors].

The effects of cimetidine have been evaluated in 10 normal subjects on cutaneous delayed reactions in vivo, and on E rosette forming cells in vitro, in order to define the significance of the lymphocytes H2 receptors in cell-mediated immunity. The results show the immuno-suppressive activity of histamine, but do not allow us to hypothesize an immuno-regulatory action of cimetidine.

Adult↗
PubMed1979

Suppressor effects of histamine on SK/SD delayed hypersensitivity reactions in man and on E-rosette-forming cells.

The effects of histamine on delayed hypersensitivity cutaneous reactions and on the formation of E-rosettes has been evaluated. In vivo, concentrations of 10(-3.6)M of histamine HCL significantly suppresses the cell-mediated reaction to antigen SK/SD at 24 and at 48 h. In vitro, amine significantly inhibits the formation of E-rosettes in normal subjects. The inhibitory effect is significant at concentrations of 10(-4)M for an incubation period at 37 degrees C of 2 h with lymphocytes. The suppressor effect of histamine in vivo may be mediated by an histamine-induced suppressor factor, while the one in vitro by an increase of intracellular cAMP. No anti-H1 and anti-H2 drugs have been employed but the effects of histamine probably depend on H2-receptors.

Adult↗
PubMed1977

Lactoferrin in synovial fluid.

The synovial lactoferrin (LF) concentrations of 59 patients with active rheumatoid arthritis were determined. The median value of LF was 4.64+/-3.59 mg/100 ml, but in degenerative arthropathy the levels of the metal-protein were much lower and often not titratable. These variations in the LF concentration explain the low blood-iron levels in inflammatory states, even when the concentration of the metal-protein is not statistically correlated in inflammatory tests, IgG, complement fractions (of the normal or alternate pathway), or variations of other protein fractions of leucocyte origin.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Relationship between physical impairment, psychological variables and pain in rheumatoid disability. An analysis of their relative impact.

Forty-two consecutive female rheumatoid patients were given the AIMS questionnaire in order to determine their disability. Twenty-one had a second assessment one year later. Factorial analysis showed that the Italian version fully respects the construct of the original test. In fact four main factors (the physical, psychological, social and pain dimensions) arose, explaining 44.8%, 13.6%, 11.4% and 9% of the total variance, respectively. A close relationship was demonstrated between psychological variables, namely depression, and physical impairment, as shown by the correlation coefficient matrix. In order to determine whether depression might influence the ultimate outcome twenty-one patients were separated into two subsets according to their initial depression (greater than 5, less than 5). After one year, dexterity and pain were significantly worse in those with the highest depression score. This study shows that the psychological variables, in addition to physical impairment and pain, are of utmost importance in the outcome of rheumatoid patients.

Adult↗
PubMedDate not supplied

DISH and ankylosing spondylitis. Case report and review of the literature.

Ankylosing spondylitis (A.Sp.) and diffuse idiopatic skeletal hyperostosis (DISH), represent the most common inflammatory and degenerative enthesopathies, respectively. Despite their rather frequent occurrence in the rheumatic disease care setting, few case reports of their simultaneous presence in the same patient have appeared in the literature. We describe here a further observation and review the rheumatologic literature.

Aged↗
PubMedDate not supplied

Long-term outcome with gold thiosulphate and tiopronin in 200 rheumatoid patients.

Two hundred rheumatoid patients were prospectively studied over a five-year period. One hundred and three received tiopronin (T) and 97 were treated with gold thiosulphate (GTS). At the end of the five-year period, similar percentages of patients dropped out because of lack of efficacy or because of major toxicities. Likewise, the percentages of patients still receiving the original drug in the two drug regimens at the 5th year of follow-up were 27.8% (GTS) vs. 25.2% (T), respectively.

Administration, Oral↗